Publications by authors named "A Z El Ghatit"

22 Publications

Association of IFIS and vasodepressor medication.

Authors:
Ali M El-Ghatit

J Cataract Refract Surg 2006 Apr;32(4):546-7

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http://dx.doi.org/10.1016/j.jcrs.2006.01.009DOI Listing
April 2006

Presumed periorbital lupus vulgaris with ocular extension.

Ophthalmology 1999 Oct;106(10):1990-3

Department of Ophthalmology, Alexandria University School of Medicine, Egypt.

Objective: To report an unusual case of lupus vulgaris that spread to the left anterior ocular surface.

Design: Case report.

Participant: An 18-year-old woman presented with an 8-month history of an infiltrative skin lesion affecting the left lower eyelid and cheek area, left globe, right lacrimal sac area, together with a cystic lesion in the foot area. TESTING/INTERVENTION: The authors describe the clinical findings, radiologic study, and histopathologic study of the conjunctiva, skin, liver, and ankle lesion. The patient was treated with antituberculous medications for 3 months.

Main Outcome Measures: Healing of the skin, conjunctival, and bone lesions.

Results: The lesion of the face healed, leaving scar tissue. The left eye showed symblepharon with loss of its anterior surface features. The right eye showed no symblepharon, the bones of the foot healed with no deformity, and the liver function test results normalized after 3 months of antituberculous medications.

Conclusion: Lupus vulgaris can be associated with multiple system involvement. Its clinical presentation and behavior depend on the patient's immunity and duration of the disease. Early diagnosis and appropriate management may cure the disease with no life-threatening sequelae.
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http://dx.doi.org/10.1016/S0161-6420(99)90413-XDOI Listing
October 1999

Pathogenesis of corneal epithelial defects: role of plasminogen activator.

Curr Eye Res 1991 May;10(5):381-98

Cornea Unit, Eye Research Institute, Boston, MA.

Previous studies have suggested that the plasminogen activator (PA)/plasmin system has important roles in the pathogenesis of epithelial defects and stromal ulceration. The current studies were performed to localize PA species and identify them as tissue-type PA (tPA) or urokinase-like PA (uPA) as the two have distinct regulatory properties potentially related to the mechanisms of defect formation and ulceration. To determine the locations and types of PA species, antibodies to tPA or to uPA or the drug amiloride (a drug that inhibits uPA but not tPA) were incorporated into fibrin/fibronectin (Fn) clots overlying frozen sections to block regional fibrinolysis. Normal rabbit eyes showed tPA activity in association with corneal epithelium, corneal endothelium, and ciliary body/iris. After epithelial scrape or alkali burn, corneal tPA activity was detected initially in the defect zone colinear with fibrin/Fn and was symmetrical to resurfacing epithelium. The observation that initial fibrinolysis occurs in the defect zone, known to contain fibrin/Fn, suggests that tPA from blood (limbal vascular endothelium) and/or from corneal epithelium has become bound to (and activated on) the fibrin/Fn. PA activity was also associated with the leading edges of migrating epithelium post-scrape and post-burn and was not inhibited by antibodies to either tPA or uPA but was inhibited by amiloride. After complete closure of the primary defect post-scrape, only tPA appeared to be associated with the epithelium in that all PA activity was inhibited by antibodies to tPA. The observation that leading edge activity post-burn, in correlation with the formation of secondary defects, continues to be inhibitable by amiloride but not by antibodies to tPA suggests that uPA remains abnormally on the leading edge, and that sustained uPA activity in that location results in inappropriate degradation of subepithelial fibrin/Fn to result in a defect. Successful regulation of uPA activity at the leading edge of corneal epithelium post-burn would be expected to be useful therapeutically in the healing of epithelial defects and the prevention of stromal ulceration.
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http://dx.doi.org/10.3109/02713689109001747DOI Listing
May 1991

Body composition of patients with spinal cord injury.

Eur J Clin Nutr 1988 Sep;42(9):765-73

Department of Physiology, Medical College of Wisconsin, Milwaukee.

Body composition of 10 control subjects and 37 spinal cord injured (SCI) patients was measured by dilution of 3H2O and Na2 35SO4. SCI patients were classified into four groups by ascending level of lesion, low and high paraplegics and low and high quadriplegics. The studies show diminishing total body water, intracellular water, lean body mass and body cell mass and increasing fat mass with higher spinal lesions. No differences in body weight or extracellular water were observed so that the ratio of extracellular water/total body water was increased as the level of injury increased.
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September 1988

Daily energy expenditure and basal metabolic rates of patients with spinal cord injury.

Arch Phys Med Rehabil 1985 Jul;66(7):420-6

Basal metabolic rate (BMR) and daily energy expenditure were measured in 48 men with complete traumatic transections of the spinal cord. Subjects were classified according to their residual motor function as high or low quadriplegic (HQ, LQ) or as high or low paraplegic (HP, LP). Measured BMR was lower than predicted BMR in almost all of the subjects and was significantly lower in the HQ group than in the other groups. High quadriplegics also expended significantly less energy while awake and over a 24-hour period than did the other groups. Measurements of BMR and total energy expenditure were significantly correlated with the level of lesion. The data provide a basis for establishing guidelines on the average energy needs of patients with spinal cord injury.
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July 1985
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