Alexandra Trkola

Alexandra Trkola

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Alexandra Trkola

Alexandra Trkola

Publications by authors named "Alexandra Trkola"

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Widespread B cell perturbations in HIV-1 infection afflict naive and marginal zone B cells.

J Exp Med 2019 Sep 20;216(9):2071-2090. Epub 2019 Jun 20.

Institute of Medical Virology, University of Zurich, Zurich, Switzerland

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http://dx.doi.org/10.1084/jem.20181124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719425PMC
September 2019

Correlates of broadly neutralizing antibody development.

Curr Opin HIV AIDS 2019 Jul;14(4):279-285

Institute of Medical Virology, University of Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1097/COH.0000000000000552DOI Listing
July 2019

Lower Broadly Neutralizing Antibody Responses in Female Versus Male HIV-1 Infected Injecting Drug Users.

Viruses 2019 04 25;11(4). Epub 2019 Apr 25.

Department of Experimental Immunology, Amsterdam UMC, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.

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http://dx.doi.org/10.3390/v11040384DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6521154PMC
April 2019

OMIP-047: High-Dimensional phenotypic characterization of B cells.

Cytometry A 2018 06 21;93(6):592-596. Epub 2018 May 21.

Institute of Medical Virology, University of Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1002/cyto.a.23488DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6704361PMC
June 2018

Development of a high-throughput bead based assay system to measure HIV-1 specific immune signatures in clinical samples.

J Immunol Methods 2018 03 22;454:48-58. Epub 2017 Dec 22.

Institute of Medical Virology, University of Zurich, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.jim.2017.12.003DOI Listing
March 2018

Influence of time to diagnosis of severe influenza on antibiotic use, length of stay, isolation precautions, and mortality: a retrospective study.

Influenza Other Respir Viruses 2017 07 12;11(4):337-344. Epub 2017 May 12.

Division of Infectious Diseases and Hospital Epidemiology, University Hospital and University of Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1111/irv.12454DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5485868PMC
July 2017

MinVar: A rapid and versatile tool for HIV-1 drug resistance genotyping by deep sequencing.

J Virol Methods 2017 02 17;240:7-13. Epub 2016 Nov 17.

Institute of Medical Virology, University of Zurich, Zurich, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.jviromet.2016.11.008DOI Listing
February 2017

HIV-1 resistance to neutralizing antibodies: Determination of antibody concentrations leading to escape mutant evolution.

Virus Res 2016 06 19;218:57-70. Epub 2015 Oct 19.

Institute of Medical Virology, University of Zurich, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.virusres.2015.10.009DOI Listing
June 2016

The HIV-1 Entry Process: A Stoichiometric View.

Trends Microbiol 2015 Dec 2;23(12):763-774. Epub 2015 Nov 2.

Institute of Medical Virology, University of Zürich, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.tim.2015.09.003DOI Listing
December 2015

Unbiased metagenomic sequencing complements specific routine diagnostic methods and increases chances to detect rare viral strains.

Diagn Microbiol Infect Dis 2015 Oct 29;83(2):133-8. Epub 2015 Jun 29.

Institute of Medical Virology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.diagmicrobio.2015.06.017DOI Listing
October 2015

Off-target-free gene delivery by affinity-purified receptor-targeted viral vectors.

Nat Commun 2015 Feb 10;6:6246. Epub 2015 Feb 10.

1] Molecular Biotechnology and Gene Therapy, Paul-Ehrlich-Institut, 63225 Langen, Germany [2] German Cancer Consortium, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1038/ncomms7246DOI Listing
February 2015

The orientation of HIV-1 gp120 binding to the CD4 receptor differentially modulates CD4+ T cell activation.

J Immunol 2015 Jan 3;194(2):637-49. Epub 2014 Dec 3.

Institute of Microbiology, Swiss Federal Institute of Technology Zurich, 8093 Zurich, Switzerland;

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http://www.jimmunol.org/lookup/doi/10.4049/jimmunol.1401863
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http://dx.doi.org/10.4049/jimmunol.1401863DOI Listing
January 2015

Different infectivity of HIV-1 strains is linked to number of envelope trimers required for entry.

PLoS Pathog 2015 Jan 8;11(1):e1004595. Epub 2015 Jan 8.

Institute of Medical Virology, University of Zürich, Zürich, Switzerland.

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http://dx.doi.org/10.1371/journal.ppat.1004595DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4287578PMC
January 2015

HIV: Potency needs constancy.

Authors:
Alexandra Trkola

Nature 2014 Oct;514(7523):442-3

Institute of Medical Virology, University of Zurich, 8057 Zurich, Switzerland.

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http://dx.doi.org/10.1038/514442aDOI Listing
October 2014

Mathematical models: a key to understanding HIV envelope interactions?

J Immunol Methods 2013 Dec 13;398-399:1-18. Epub 2013 Sep 13.

Institute of Medical Virology, University of Zurich, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.jim.2013.09.002DOI Listing
December 2013

Immune senescence: relative contributions of age and cytomegalovirus infection.

PLoS Pathog 2012 16;8(8):e1002850. Epub 2012 Aug 16.

Division of Infectious Diseases and Hospital Epidemiology, University Hospital of Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1371/journal.ppat.1002850DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3420944PMC
December 2012

HIV vaccines: an attainable goal?

Swiss Med Wkly 2012 2;142:w13535. Epub 2012 Mar 2.

Institute of Medical Virology, University of Zurich, Switzerland.

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http://dx.doi.org/10.4414/smw.2012.13535DOI Listing
May 2012

Tailored enrichment strategy detects low abundant small noncoding RNAs in HIV-1 infected cells.

Retrovirology 2012 Mar 29;9:27. Epub 2012 Mar 29.

Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Rämistrasse 100, CH-8091 Zurich, Switzerland.

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http://retrovirology.biomedcentral.com/articles/10.1186/1742
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http://dx.doi.org/10.1186/1742-4690-9-27DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3341194PMC
March 2012

Synthetic virus-like particles and conformationally constrained peptidomimetics in vaccine design.

Chembiochem 2011 Dec 11;12(18):2829-36. Epub 2011 Nov 11.

Chemistry Department, University of Zürich, Winterthurerstrasse 190, 8057 Zürich, Switzerland.

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http://doi.wiley.com/10.1002/cbic.201100586
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http://dx.doi.org/10.1002/cbic.201100586DOI Listing
December 2011

Therapeutic antibodies in HIV treatment--classical approaches to novel advances.

Curr Pharm Des 2010 ;16(33):3754-66

University of Zurich, Institute of Medical Virology. Winterthurerstrasse 190, Zurich 8045 Switzerland.

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http://dx.doi.org/10.2174/138161210794079245DOI Listing
May 2011

Peptidomimetic inhibitors targeting the CCR5-binding site on the human immunodeficiency virus type-1 gp120 glycoprotein complexed to CD4.

Chem Commun (Camb) 2010 Nov 8;46(41):7754-6. Epub 2010 Sep 8.

Department of Chemistry, University of Zurich, Winterthurerstrasse 190, 8057 Zurich X, Switzerland.

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http://dx.doi.org/10.1039/c0cc02913kDOI Listing
November 2010

HIV sensitivity to neutralization is determined by target and virus producer cell properties.

AIDS 2009 Aug;23(13):1659-67

Institute of Medical Virology, University of Zurich, Switzerland.

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http://dx.doi.org/10.1097/QAD.0b013e32832e9408DOI Listing
August 2009

Divergent effects of cell environment on HIV entry inhibitor activity.

AIDS 2009 Jul;23(11):1319-27

Institute of Medical Virology, University of Zurich, University Hospital Zurich, Switzerland.

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http://dx.doi.org/10.1097/qad.0b013e32832d92c2DOI Listing
July 2009

HIV-1 superinfection in an HIV-2-infected woman with subsequent control of HIV-1 plasma viremia.

Clin Infect Dis 2009 Jun;48(11):e117-20

Division of Infectious Diseases and Hospital Epidemiology, University of Zurich, Zurich, Switzerland.

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https://academic.oup.com/cid/article-lookup/doi/10.1086/5989
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http://dx.doi.org/10.1086/598987DOI Listing
June 2009

Estimating the stoichiometry of human immunodeficiency virus entry.

J Virol 2009 Feb 19;83(3):1523-31. Epub 2008 Nov 19.

Integrative Biology, ETH Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1128/JVI.01764-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2620894PMC
February 2009

HIV rebounds from latently infected cells, rather than from continuing low-level replication.

Proc Natl Acad Sci U S A 2008 Oct 20;105(43):16725-30. Epub 2008 Oct 20.

Department of Medicine, Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zürich, CH-8091 Zurich, Switzerland.

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http://dx.doi.org/10.1073/pnas.0804192105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2575487PMC
October 2008

In vivo efficacy of human immunodeficiency virus neutralizing antibodies: estimates for protective titers.

J Virol 2008 Feb 21;82(3):1591-9. Epub 2007 Nov 21.

Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Rämistrasse 100, 8091 Zürich, Switzerland.

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http://dx.doi.org/10.1128/JVI.01792-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2224433PMC
February 2008

Antibody responses in primary HIV-1 infection.

Curr Opin HIV AIDS 2008 Jan;3(1):45-51

Department of Pathology, University of California, San Diego, California, USA.

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http://dx.doi.org/10.1097/COH.0b013e3282f310aeDOI Listing
January 2008

In vivo and in vitro escape from neutralizing antibodies 2G12, 2F5, and 4E10.

J Virol 2007 Aug 13;81(16):8793-808. Epub 2007 Jun 13.

Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Rämistrasse 100, 8091 Zurich, Switzerland.

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http://dx.doi.org/10.1128/JVI.00598-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1951363PMC
August 2007

Positive in vivo selection of the HIV-1 envelope protein gp120 occurs at surface-exposed regions.

J Infect Dis 2007 Jul 5;196(2):313-20. Epub 2007 Jun 5.

Department of Medicine, Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zürich, Zürich, CH-8091, Switzerland.

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http://dx.doi.org/10.1086/518935DOI Listing
July 2007

Use of alternate coreceptors on primary cells by two HIV-1 isolates.

Virology 2005 Aug;339(1):136-44

AIDS Virus Research Unit, National Institute for Communicable Diseases, Private Bag X4, Sandringham 2131, Johannesburg, South Africa.

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http://dx.doi.org/10.1016/j.virol.2005.05.027DOI Listing
August 2005

Complement dependent trapping of infectious HIV in human lymphoid tissues.

AIDS 2005 Mar;19(5):481-6

Department of Hygiene, Microbiology and Social Medicine, Innsbruck Medical University and Ludwig-Boltzmann-Institute for AIDS Research, 6020 Innsbruck, Austria.

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http://dx.doi.org/10.1097/01.aids.0000162336.20439.8dDOI Listing
March 2005

HIV-host interactions: vital to the virus and key to its inhibition.

Authors:
Alexandra Trkola

Curr Opin Microbiol 2004 Oct;7(5):555-9

Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, 8091 Zurich, Switzerland.

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http://dx.doi.org/10.1016/j.mib.2004.08.001DOI Listing
October 2004

HIV-host interactions: vital to the virus and key to its inhibition.

Authors:
Alexandra Trkola

Curr Opin Microbiol 2004 Aug;7(4):407-11

Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, 8091 Zurich, Switzerland.

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http://dx.doi.org/10.1016/j.mib.2004.06.002DOI Listing
August 2004

RANTES (CCL5) uses the proteoglycan CD44 as an auxiliary receptor to mediate cellular activation signals and HIV-1 enhancement.

Blood 2003 Aug 24;102(4):1169-77. Epub 2003 Apr 24.

Division of Infectious Diseases, Department of Medicine, University Hospital, Zurich, Switzerland.

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http://dx.doi.org/10.1182/blood-2003-02-0488DOI Listing
August 2003

Shifts in cell-associated HIV-1 RNA but not in episomal HIV-1 DNA correlate with new cycles of HIV-1 infection in vivo.

Antivir Ther 2003 Apr;8(2):97-104

Division of Infectious Diseases and Hospital Epidemiology, Department of Medicine, University Hospital Zürich, 8091 Zürich, Switzerland.

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April 2003