Publications by authors named "A S Avedisova"

57 Publications

Validation of the Generalized Anxiety Disorder-7 (GAD-7) in Russian people with epilepsy.

Epilepsy Behav 2021 10 6;123:108269. Epub 2021 Sep 6.

Moscow Research and Clinical Center for Neuropsychiatry, Moscow, Russian Federation; Pirogov Russian National Research Medical University, Moscow, Russian Federation.

Objective: To assess the capacity of Generalized Anxiety Disorder-7 (GAD-7) to detect anxiety disorders in a Russian sample of patients with epilepsy and to validate this instrument for rapid screening of anxiety in these patients.

Methods: Study included 233 patients with epilepsy, both inpatients and outpatients. For all patients Mini-International Neuropsychiatric Interview was conducted as a gold standard for diagnosis of mental disorders. All patients also completed the questionnaires - the Russian version of GAD-7 and Hospital Anxiety and Depression Scale (HADS) to assess convergent validity. Chi-square and Fisher's exact tests were used to compare categorical variables, and the Mann-Whitney test was used for the quantitative ones. Internal consistency was assessed using Cronbach's alpha, Cronbach's alpha at point deletion, and corrected point-to-point correlation. ROC analysis was used to evaluate the properties of the GAD-7 to determine anxiety disorders.

Results: Among 97 (41.6%) patients with epilepsy diagnosed with any anxiety disorders, 42 (18%) had panic disorder, 37 (15.9%) had agoraphobia, 17 (7.3%) had social anxiety disorder, and 64 (27.5%) had generalized anxiety disorder; 42 patients (18%) showed a combination of several anxiety disorders. The overall GAD-7 score was similar to other epilepsy studies, but higher cutoff scores characterize our sample. The scale performed well in detecting any anxiety disorder with the AUC of 0.866 and the optimal cutoff point > 8 points, and in detecting GAD with AUC = 0.922 and the optimal cutoff point > 9 points, showing overall acceptable sensitivity.

Conclusion: Russian version of the GAD-7 could be used as a screening tool for any anxiety disorders in PWE with the optimal cutoff score > 8 points.
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http://dx.doi.org/10.1016/j.yebeh.2021.108269DOI Listing
October 2021

[Psychogenic non-epileptic seizures].

Zh Nevrol Psikhiatr Im S S Korsakova 2021 ;121(8):112-118

Research and Clinical Center for Neuropsychiatry, Moscow, Russia.

The review provides epidemiological data and discuss the associated burden of non-epileptic seizures (PNES). Data on the prevalence, socio-demographic and clinical risk factors for the development of PNES are presented. The hypotheses of the PNES origin, including the contribution of psychological trauma, are considered. We also describe contemporary methods for differential diagnosis of epileptic seizures and PNES, including biomarkers and the use of diagnostic questionnaires. Special attention is given to the issues of the psychiatric comorbidity of PNES.
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http://dx.doi.org/10.17116/jnevro2021121081112DOI Listing
September 2021

[Clinical variants and types of course of separation anxiety disorder in adults].

Zh Nevrol Psikhiatr Im S S Korsakova 2021 ;121(5):19-25

Serbsky National Medical Research Center for Psychiatry and Narcology, Moscow, Russia.

Objective: To study clinical manifestations of separation anxiety disorder (SAD) in adults with nonpsychotic mental disorders.

Material And Methods: Fifty outpatients over 18 years of age with SAD and comorbid non-psychotic mental disorders were assessed for diagnosis by MINI and the Structured Clinical Interview for Separation Anxiety Symptoms (SCI-SAS), the Adult Separation Anxiety Self-Report Checklist (ASA-27), HARS, the Experiences in Close Relationship Scale (ECR), the Personality Inventory for DSM-5 (PID-5), the Quality of Life Enjoyment and Satisfaction Questionnaire (Q-LES-Q).

Results And Conclusion: Two clinical variants of the disorder: affective and cognitive-behavioral as well as two variants of the course: with onset in childhood and in adults are identified. Clinical variants and types differ in the spectrum of comorbidity, objects and styles of attachment, personality characteristics as well as correlations and prognosis.
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http://dx.doi.org/10.17116/jnevro202112105119DOI Listing
June 2021

[Clinical variants and types of course of separation anxiety disorder in adults].

Zh Nevrol Psikhiatr Im S S Korsakova 2021 ;121(5):19-25

Serbsky National Medical Research Center for Psychiatry and Narcology, Moscow, Russia.

Objective: To study clinical manifestations of separation anxiety disorder (SAD) in adults with nonpsychotic mental disorders.

Material And Methods: Fifty outpatients over 18 years of age with SAD and comorbid non-psychotic mental disorders were assessed for diagnosis by MINI and the Structured Clinical Interview for Separation Anxiety Symptoms (SCI-SAS), the Adult Separation Anxiety Self-Report Checklist (ASA-27), HARS, the Experiences in Close Relationship Scale (ECR), the Personality Inventory for DSM-5 (PID-5), the Quality of Life Enjoyment and Satisfaction Questionnaire (Q-LES-Q).

Results And Conclusion: Two clinical variants of the disorder: affective and cognitive-behavioral as well as two variants of the course: with onset in childhood and in adults are identified. Clinical variants and types differ in the spectrum of comorbidity, objects and styles of attachment, personality characteristics as well as correlations and prognosis.
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http://dx.doi.org/10.17116/jnevro202112105119DOI Listing
June 2021

[Clinical variants and types of course of separation anxiety disorder in adults].

Zh Nevrol Psikhiatr Im S S Korsakova 2021 ;121(5):19-25

Serbsky National Medical Research Center for Psychiatry and Narcology, Moscow, Russia.

Objective: To study clinical manifestations of separation anxiety disorder (SAD) in adults with nonpsychotic mental disorders.

Material And Methods: Fifty outpatients over 18 years of age with SAD and comorbid non-psychotic mental disorders were assessed for diagnosis by MINI and the Structured Clinical Interview for Separation Anxiety Symptoms (SCI-SAS), the Adult Separation Anxiety Self-Report Checklist (ASA-27), HARS, the Experiences in Close Relationship Scale (ECR), the Personality Inventory for DSM-5 (PID-5), the Quality of Life Enjoyment and Satisfaction Questionnaire (Q-LES-Q).

Results And Conclusion: Two clinical variants of the disorder: affective and cognitive-behavioral as well as two variants of the course: with onset in childhood and in adults are identified. Clinical variants and types differ in the spectrum of comorbidity, objects and styles of attachment, personality characteristics as well as correlations and prognosis.
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http://dx.doi.org/10.17116/jnevro202112105119DOI Listing
June 2021
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