Publications by authors named "A Rodríguez Pérez"

3,509 Publications

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Curcumin induces peripheral antinociception by opioidergic and cannabinoidergic mechanism: Pharmacological evidence.

Life Sci 2022 Jan 12:120279. Epub 2022 Jan 12.

Department of Pharmacology, Institute of Biological Sciences, UFMG, Belo Horizonte, Brazil. Electronic address:

Background: Curcumin is one of the compounds present in plants of the genus Curcuma sp., being very used not only as condiment but also with medicinal purposes. As an analgesic, papers highlight the efficacy of curcumin in the treatment of various types of pain.

Aims: In this study we evaluated the peripheral antinociceptive effect of curcumin and by which mechanisms this effect is induced.

Main Methods: The mice paw pressure test was used on animals which had increased pain sensitivity by intraplantar injection of carrageenan. All the drugs were administered in the right hind paw.

Key Findings: Curcumin was administered to the right hind paw animals induced antinociceptive effect. Non -selective antagonist of opioid receptors naloxone reverted the antinociceptive effect induced by curcumin. Selective antagonists for μ, δ and κ opioid receptors clocinnamox, naltrindole and nor- binaltorphimine, respectively, reverted the antinociceptive effect induced by curcumin. Bestatin, enkephalinases inhibitor that degrade peptides opioids, did not change the nociceptive response. Selective antagonists for CB and CB cannabinoid receptors, AM251 and AM630, respectively, reversed the antinociceptive effect induced by curcumin. The MAFP inhibitor of the enzyme FAAH which breaks down anandamide, JZL184, enzyme inhibitor MAGL which breaks down the 2-AG, as well as the VDM11 anandamide reuptake inhibitor potentiated the antinociceptive effect of curcumin.

Significance: These results suggest that curcumin possibly peripheral antinociception induced by opioid and cannabinoid systems activation and possibly for endocannabinoids and opioids release.
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http://dx.doi.org/10.1016/j.lfs.2021.120279DOI Listing
January 2022

Numerical analysis of electrohydrodynamic instability in dielectric-liquid-gas flows subjected to unipolar injection.

Phys Rev E 2021 Dec;104(6-2):065109

Key Laboratory of Aerospace Thermophysics, School of Energy Science and Engineering, Harbin Institute of Technology, Harbin 150001, People's Republic of China.

In this work, the electrohydrodynamic instability induced by a unipolar charge injection is extended from a single-phase dielectric liquid to a two-phase system that consists of a liquid-air interface. A volume-of-fluid model-based two-phase solver was developed with simplified Maxwell equations implemented in the open-source platform OpenFOAM. The numerically obtained critical value for the linear stability matches well with the theoretical values. To highlight the effect of the slip boundary at interface, the deformation of the interface is ignored. A bifurcation diagram with hysteresis loop linking the linear and finite-amplitude criteria, which is U_{f}=0.059, was obtained in this situation. It is concluded that the lack of viscous effect at interface leads to a significant increase in the flow intensity, which is the reason for the smaller instability threshold in two-phase system. The presence of interface also changes the flow structure and results in a shear distribution of electric force, which may play an important role in the interface deformation.
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http://dx.doi.org/10.1103/PhysRevE.104.065109DOI Listing
December 2021

Primary prevention recommendations to reduce the risk of cognitive decline.

Alzheimers Dement 2022 Jan 13. Epub 2022 Jan 13.

McCance Center for Brain Health, Massachusetts General Hospital, Boston, MA USA, Boston, Massachusetts, USA.

Introduction: Few resources address steps clinicians can take to help patients reduce their risk of dementia, despite growing recognition that brain health can be optimized and that risk reduction for cognitive decline can be accomplished by lifestyle modifications.

Methods: To address this gap, UsAgainstAlzheimer's convened a risk reduction workgroup (RRWG) to review existing evidence and develop recommendations for primary care clinicians discussing cognitive decline and risk reduction with their patients.  RESULTS: The RRWG produced 11 consensus-based recommendations and implementation strategies across six topics: neurovascular risk management, physical activity, sleep, nutrition, social isolation, and cognitive stimulation.  DISCUSSION: These recommendations are a first step for clinicians to address brain health with patients and potentially help them prevent cognitive decline. To ensure there is routine care for brain health, proper incentives and policies must be instituted and more education for consumers should be provided.
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http://dx.doi.org/10.1002/alz.12535DOI Listing
January 2022

SARS-CoV-2 Cycle Thresholds, Poverty, Race, and Clinical Outcomes.

WMJ 2021 Dec;120(4):301-304

Division of Infectious Diseases, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin,

Background: Poverty and high viral load are associated with worse outcomes among COVID-19 patients.

Methods: We included patients admitted to Froedtert Health between March 16 and June 1, 2020. SARS-CoV-2 viral load was proxied by cycle-threshold values. To measure poverty, we used Medicaid or uninsured status and residence in socially disadvantaged areas. We assessed the association between viral load and length of stay and discharge disposition, while controlling for demographics and confounders.

Results: Higher viral load was associated with longer length of stay (coefficient -0.02; 95% CI, -0.04 to 0.01; P = 0.006) and higher likelihood of death (coefficient -0.11; 95% CI, -0.17 to -0.06; P < 0.001). Poverty, residence in disadvantaged areas, and race were not.

Discussion: This study confirms a relationship of viral load with in-hospital death, even after controlling for race and poverty.
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December 2021

Dialysis staff-reported impact of COVID-19 on early kidney transplant steps.

Kidney Int Rep 2022 Jan 7. Epub 2022 Jan 7.

Division of Transplantation, Department of Surgery, Emory University School of Medicine, Atlanta, Georgia.

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http://dx.doi.org/10.1016/j.ekir.2022.01.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8739365PMC
January 2022
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