Aarti Sawant Basak

Aarti Sawant Basak

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Aarti Sawant Basak

Aarti Sawant Basak

Publications by authors named "Aarti Sawant Basak"

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Physiologically Relevant, Humanized Intestinal Systems to Study Metabolism and Transport of Small Molecule Therapeutics.

Drug Metab Dispos 2018 11 20;46(11):1581-1587. Epub 2018 Aug 20.

Pfizer Worldwide Research & Development, Clinical Pharmacology, 1 Portland Street, Cambridge, MA 02139 (A.S.-B.); Pfizer Worldwide Research & Development, PDM, Eastern Point Road, Groton, 06340 (A.D.R.); Pfizer Worldwide Research & Development, Inflammation and Immunology, 1 Portland Street, Cambridge, MA 02139 (M.L., M.K.); Pfizer Worldwide Research & Development, Discovery Sciences, Eastern Point Road, Groton, 06340 (R.D.); Assistant Professor, Department of Pharmaceutics, UWRAPT H268, Health Science Building, Seattle (B.P.); Pfizer Worldwide Research & Development, Early Clinical Development, Clinical Pharmacology, 1 Portland Street, Cambridge, MA 02139 (N.T.).

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http://dmd.aspetjournals.org/lookup/doi/10.1124/dmd.118.0827
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http://dx.doi.org/10.1124/dmd.118.082784DOI Listing
November 2018

Emerging Models of Drug Metabolism, Transporters, and Toxicity.

Drug Metab Dispos 2018 11;46(11):1556-1561

Pfizer Worldwide Research & Development, Clinical Pharmacology, Cambridge, Massachusetts (A.S.-B.) and Pfizer Worldwide Research & Development, Pharmacokinetics, Dynamics, and Metabolism, Groton, Connecticut (R.S.O.).

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http://dx.doi.org/10.1124/dmd.118.084293DOI Listing
November 2018

Quantitative Translational Analysis of Brain Kynurenic Acid Modulation via Irreversible Kynurenine Aminotransferase II Inhibition.

Mol Pharmacol 2018 08 31;94(2):823-833. Epub 2018 May 31.

Systems Modeling and Simulation Group, Pharmacokinetics, Dynamics and Metabolism, Medicine Design (C.C., C.L., T.S.M.), Neuroscience and Pain Research Unit (W.H., L.E.Z., M.A.S., K.A.W., C.A.S., B.M.C., A.D., J.B.T., P.V.), and Pharmacokinetics, Dynamics and Metabolism, Medicine Design (K.R.F., S.S.G., H.R., A.S.-B., J.L.), Worldwide Research and Development, Pfizer Inc., Cambridge, Massachusetts.

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http://dx.doi.org/10.1124/mol.118.111625DOI Listing
August 2018

Metabolism of a 5HT Antagonist, 2-Methyl-1-(Phenylsulfonyl)-4-(Piperazin-1-yl)-1H-Benzo[d]imidazole (SAM-760): Impact of Sulfonamide Metabolism on Diminution of a Ketoconazole-Mediated Clinical Drug-Drug Interaction.

Drug Metab Dispos 2018 Jul 25;46(7):934-942. Epub 2018 Apr 25.

Pfizer Worldwide Research and Development, Pharmacokinetics, Dynamics and Metabolism (PDM), Cambridge, Massachusetts (A.S.-B.); Pfizer Worldwide Research and Development, Pharmacokinetics, Dynamics and Metabolism (PDM), Groton, Connecticut (R.S.O., A.D., H.G., S.T.); Pfizer Global Product Development, Groton, Connecticut (P.L.); Pfizer Worldwide Research and Development Pharmaceutical Sciences Chemical Research and Development, Groton, Connecticut (K.S.); Pfizer Worldwide Research and Development, Research Statistics, Cambridge, Massachusetts (J.M.); and Pfizer Neuroscience and Pain Research Unit, Worldwide Research and Development, Cambridge, Massachusetts (T.A.C.).

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http://dx.doi.org/10.1124/dmd.118.080457DOI Listing
July 2018

Estimation of Circulating Drug Metabolite Exposure in Human Using In Vitro Data and Physiologically Based Pharmacokinetic Modeling: Example of a High Metabolite/Parent Drug Ratio.

Drug Metab Dispos 2018 02 17;46(2):89-99. Epub 2017 Nov 17.

Department of Pharmacokinetics, Dynamics, and Drug Metabolism, Pfizer Inc., Groton, Connecticut (RSO, JL, EK, EPK, and RSO), and Cambridge, Massachusetts (ASB); and Department of Clinical Pharmacology, Pfizer Inc., Cambridge, Massachusetts (SD and TN).

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http://dmd.aspetjournals.org/lookup/doi/10.1124/dmd.117.0782
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http://dx.doi.org/10.1124/dmd.117.078279DOI Listing
February 2018

Strategies toward optimization of the metabolism of a series of serotonin-4 partial agonists: investigation of azetidines as piperidine isosteres.

Xenobiotica 2016 Dec 7;46(12):1112-1121. Epub 2016 Mar 7.

d Department of Pharmacokinetics , Dynamics, and Metabolism , Cambridge , MA , USA.

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http://dx.doi.org/10.3109/00498254.2016.1152522DOI Listing
December 2016