Publications by authors named "A N Di Marco"

1,060 Publications

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Mind the gap: Transesophageal echocardiography aids detection of pseudo-coarctation during thoracoabdominal surgery.

JTCVS Tech 2021 Apr 19;6:106-109. Epub 2021 Jan 19.

Department of Cardiothoracic Surgery, St Bartholomew's Hospital, London, United Kingdom.

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http://dx.doi.org/10.1016/j.xjtc.2021.01.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8300973PMC
April 2021

[Reply to "Antigen-detecting rapid tests or real-time PCR, what test to use and why?"]

Enferm Infecc Microbiol Clin 2021 Jul 19. Epub 2021 Jul 19.

Programa de Salud Penitenciaria. Instituto Catalán de la Salud, Cataluña, España.

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http://dx.doi.org/10.1016/j.eimc.2021.06.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8286867PMC
July 2021

Neoadjuvant chemotherapy followed by radical surgery in locally advanced vulvar carcinoma: a single-institution experience.

Tumori 2021 Jul 21:3008916211027627. Epub 2021 Jul 21.

Gynaecologic Oncology Surgical Unit, Obstetrics and Gynaecology Department, ASST-Monza, San Gerardo Hospital, Monza, Lombardia, Italy.

Background: Squamous cell carcinoma of the vulva is a rare malignancy that affects elderly women. About one-third of vulvar cancers are diagnosed in an advanced stage, requiring extensive surgery. Neoadjuvant chemotherapy (NACT) has been introduced to reduce local tumor burden. In this retrospective study, we analyze the efficacy and toxicity of NACT followed by radical surgery.

Methods: Patients with locally advanced vulvar cancer (LAVC) treated at our institution with neoadjuvant platinum and paclitaxel-based chemotherapy ± ifosfamide followed by surgery at our institution were retrospectively identified.

Results: Fourteen patients (93%) completed NACT with tolerable toxicities (G3-G4 toxicity: 30%). Thirteen patients (87%) underwent surgery. The overall clinical response rate on vulvar disease was 66% (20% complete response, 46% partial response), confirmed by histopathologic analysis, while on inguinal lymph nodes it was 69% (23% complete response, 46% partial response). At the pathologic examination, all patients had negative surgical margins. Three out of 9 patients (33%) with lesions infiltrating the urethral meatus and 4 patients out of 7 (57%) with anal involvement did not require urethral amputation or colostomy, respectively, after NACT. No severe postoperative complications were described. Overall survival at 5 years was 60%, and median overall survival was 76 months.

Conclusion: NACT followed by surgery in locally advanced vulvar cancer is well tolerated and allows surgical modulation.
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http://dx.doi.org/10.1177/03008916211027627DOI Listing
July 2021

Quality of Life and Psychosocial Impacts of the Different Restrictive Measures during One Year into the COVID-19 Pandemic on Patients with Cancer in Italy: An Ecological Study.

Int J Environ Res Public Health 2021 Jul 4;18(13). Epub 2021 Jul 4.

Health Education Observatory of the Hygiene Laboratory, Department of Human Sciences, Society and Health, University of Cassino and Southern Lazio, 03043 Cassino, Italy.

Background: The aim of the study was to assess the perceived quality of life and the psychosocial impact of the various restrictive measures due to COVID-19 pandemic on cancer patients in Italy, as well as their perception of the relationship with doctors and caregivers.

Methods: This study compares three population-based observational studies of patients with cancer carried out in three consecutive time periods characterized by different restrictive measures using a self-administered online questionnaire.

Results: Among the basic needs, psychological and medical support appeared to be prevalent; so did the need for safe transportation to reach the treatment facilities. Internet was the main source of information on the coronavirus. Although 74.6% of the total number of patients did not give up hospital therapies, 34.8% complained about variations in the continuity of treatment, with different percentages in the three samples. The majority of the sample (73.8%) was worried of being infected, but 21.9% did not share their anxieties and worries with others. The multivariate regression analysis showed that a pessimistic perception of quality of life was influenced by living in extra-urban areas and alone (OR = 1.4; OR = 2.1); while a perception of a reduced physical function result affected by the state of anxiety and stress (OR = 1.9) and the difficulties in continuity of medical assistance (OR = 2.2). The scoring of the SF-12 in the Physical Component Summary and Mental Component Summary scores showed a fluctuating trend throughout the three periods investigated.

Conclusions: It is important for health professionals, caregivers and social workers to identify the new needs in order to enhance home care interventions, personalize and optimize care, ensure continuity of care and guarantee a high quality of life even in a health emergency situation.
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http://dx.doi.org/10.3390/ijerph18137161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8297179PMC
July 2021

Broad sarbecovirus neutralization by a human monoclonal antibody.

Nature 2021 Jul 19. Epub 2021 Jul 19.

Humabs Biomed SA, a subsidiary of Vir Biotechnology, Bellinzona, Switzerland.

The recent emergence of SARS-CoV-2 variants of concern (VOC) and the recurrent spillovers of coronaviruses in the human population highlight the need for broadly neutralizing antibodies that are not affected by the ongoing antigenic drift and that can prevent or treat future zoonotic infections. Here, we describe a human monoclonal antibody (mAb), designated S2X259, recognizing a highly conserved cryptic receptor-binding domain (RBD) epitope and cross-reacting with spikes from all sarbecovirus clades. S2X259 broadly neutralizes spike-mediated entry of SARS-CoV-2 including the B.1.1.7, B.1.351, P.1, B.1.427/B.1.429 VOC, as well as a wide spectrum of human and potentially zoonotic sarbecoviruses through inhibition of ACE2 binding to the RBD. Furthermore, deep-mutational scanning and in vitro escape selection experiments demonstrate that S2X259 possesses an escape profile limited to the single substitution G504D. We show that prophylactic and therapeutic administration of S2X259 protects Syrian hamsters against challenge with the prototypic SARS-CoV-2 and the B.1.351 VOC, suggesting this mAb is a promising candidate for the prevention and treatment of emergent variants and zoonotic infections. Our data unveil a key antigenic site targeted by broadly-neutralizing antibodies and will guide the design of pan-sarbecovirus vaccines.
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http://dx.doi.org/10.1038/s41586-021-03817-4DOI Listing
July 2021
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