Publications by authors named "A Moreira"

1,896 Publications

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Potential of NbO nanofibers in photocatalytic degradation of organic pollutants.

Environ Sci Pollut Res Int 2021 Jul 23. Epub 2021 Jul 23.

Nanotechnology National Laboratory for Agriculture (LNNA), Embrapa Instrumentação, XV de Novembro St., 1452, zip code, São Carlos, SP, 13560-970, Brazil.

Various photocatalytic nanomaterials for environmental remediation have been promoted due to the pollution caused by different organic pollutants. In this study, NbO nanofibers were obtained by electrospinning technique, presenting controlled crystallinity and high specific surface area to improve the photoactivity response. The structural characterization indicated NbO nanofibers with orthorhombic phase formation. The photoluminescence measurements showed different energy levels contributing to the electronic transition events. The nanofibers with a bandgap up to 3.6 eV were applied to photocatalysis of dyes (rhodamine B (RhB) or methylene blue (MB)) and fluoxetine (FLX), listed as an emergent pollutant. In the optimized condition (pH = 9), the RhB and MB photocatalysis was 59% and 93% more efficient than photolysis due to ζ = - 50 mV ± 5 for EtOH_550 sample increased interaction with MB (cationic) compared to RhB unprotonated (pKa = 3.7). Therefore, FLX (pKa = 10.7) was selected due to protonated form at pH = 9 and showed 68% ± 1 adsorption in 30 min for EtOH_550. The FLX photocatalytic degradation under UV light irradiation was up to 17% higher than the photolytic degradation. The formation of hydroxyl radicals in the photocatalytic system (EtOH_550) was proven by the Coumarine probe assay, corroborating with the greater amount of α-[2-(methylamino)ethyl]benzylalcohol (MAEB), a by-product obtained after FLX oxidation. Additionally, the material achieved specific catalytic activity for the different organic compounds (RhB, MB, or FLX). Therefore, NbO nanofibers were efficient for degrading three different pollutants under UV light, proving a viable alternative for environmental remediation.
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http://dx.doi.org/10.1007/s11356-021-15435-8DOI Listing
July 2021

Health effects of exposure to chlorination by-products in swimming pools: Position Paper.

Allergy 2021 Jul 21. Epub 2021 Jul 21.

Department of Allergy, La Paz University Hospital, IdiPAZ, and Universidad Autónoma de Madrid, Spain.

Concerns have been raised regarding the potential negative effects on human health of water disinfectants used in swimming-pools. Among the disinfection options, the approaches using chlorine-based products have been typically preferred. Chlorine readily reacts with natural organic matter that are introduced in the water mainly through the bathers, leading to the formation of potentially harmful chlorination by-products (CBPs). The formation of CBPs is of particular concern since some have been epidemiologically associated with the development of various clinical manifestations. The higher the concentration of volatile CBPs in the water, the higher their concentration in the air above the pool, and different routes of exposure to chemicals in swimming-pools (water ingestion, skin absorption and inhalation) contribute to the individual exposome. Some CBPs may affect the respiratory and skin health of those who stay indoor for long periods, such as swimming instructors, pool staff, and competitive swimmers. Whether those who use chlorinated-pools as customers, particularly children, may also be affected has been a matter of debate. In this article, we discuss the current evidence regarding the health effects of both acute and chronic exposures in different populations (work-related exposures, intensive sports and recreational attendance) and identify the main recommendations and unmet needs for research in this area.
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http://dx.doi.org/10.1111/all.15014DOI Listing
July 2021

Pre-Treatment Neutrophil Count as a Predictor of Antituberculosis Therapy Outcomes: A Multicenter Prospective Cohort Study.

Front Immunol 2021 2;12:661934. Epub 2021 Jul 2.

Programa Acadêmico de Tuberculose da Faculdade de Medicina, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.

Background: Neutrophils have been associated with lung tissue damage in many diseases, including tuberculosis (TB). Whether neutrophil count can serve as a predictor of adverse treatment outcomes is unknown.

Methods: We prospectively assessed 936 patients (172 HIV-seropositive) with culture-confirmed pulmonary TB, enrolled in a multicenter prospective cohort study from different regions in Brazil, from June 2015 to June 2019, and were followed up to two years. TB patients had a baseline visit before treatment (month 0) and visits at month 2 and 6 (or at the end of TB treatment). Smear microscopy, and culture for (MTB) were performed at TB diagnosis and during follow-up. Complete blood counts were measured at baseline. Treatment outcome was defined as either unfavorable (death, treatment failure or TB recurrence) or favorable (cure or treatment completion). We performed multivariable logistic regression, with propensity score regression adjustment, to estimate the association between neutrophil count with MTB culture result at month 2 and unfavorable treatment outcome. We used a propensity score adjustment instead of a fully adjusted regression model due to the relatively low number of outcomes.

Results: Among 682 patients who had MTB culture results at month 2, 40 (5.9%) had a positive result. After regression with propensity score adjustment, no significant association between baseline neutrophil count (10/mm) and positive MTB culture at month 2 was found among either HIV-seronegative (OR = 1.06, 95% CI = [0.95;1.19] or HIV-seropositive patients (OR = 0.77, 95% CI = [0.51; 1.20]). Of 691 TB patients followed up for at least 18 months and up to 24 months, 635 (91.9%) were either cured or completed treatment, and 56 (8.1%) had an unfavorable treatment outcome. A multivariable regression with propensity score adjustment found an association between higher neutrophil count (10/mm) at baseline and unfavorable outcome among HIV-seronegative patients [OR= 1.17 (95% CI= [1.06;1.30]). In addition, adjusted Cox regression found that higher baseline neutrophil count (10/mm) was associated with unfavorable treatment outcomes overall and among HIV-seronegative patients (HR= 1.16 (95% CI = [1.05;1.27]).

Conclusion: Increased neutrophil count prior to anti-TB treatment initiation was associated with unfavorable treatment outcomes, particularly among HIV-seronegative patients. Further prospective studies evaluating neutrophil count in response to drug treatment and association with TB treatment outcomes are warranted.
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http://dx.doi.org/10.3389/fimmu.2021.661934DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8284392PMC
July 2021

Potential cancer risk with omalizumab? A disproportionality analysis of the WHO's VigiBase pharmacovigilance database.

Allergy 2021 Jul 16. Epub 2021 Jul 16.

Serviço de Imunoalergologia, Centro Hospitalar Universitário de São João, Porto, Portugal.

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http://dx.doi.org/10.1111/all.15008DOI Listing
July 2021

Lupus mastitis: A rare breast cancer differential diagnosis.

Clin Case Rep 2021 Jul 9;9(7):e04416. Epub 2021 Jul 9.

General Surgery Department Centro Hospitalar do Baixo Vouga Aveiro Portugal.

Lupus mastitis is an uncommon SLE breast manifestation. Clinically, it can present itself as a malignant-like mass. Therefore, a tissue biopsy is warranted to confirm the diagnosis. The treatment of this condition is pharmacological and directed to the underlying disease. The rarity of this entity demands a high degree of suspicion.
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http://dx.doi.org/10.1002/ccr3.4416DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8271243PMC
July 2021
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