Publications by authors named "A Katoulis"

130 Publications

Occupational contact allergy of construction workers in Greece: Trends during 2009-2018.

Contact Dermatitis 2021 Sep 12. Epub 2021 Sep 12.

1st Department of Dermatology and Venereology, Andreas Sygros Hospital for Skin and Venereal Diseases, National and Kapodistrian University of Athens, Faculty of Medicine, Athens, Greece.

Background: Recent trends in sensitization of construction workers present a decrease in potassium dichromate and an increase in epoxy resin sensitization.

Objectives: To present the trends of occupational contact allergy of construction workers in Greece during 2009-2018.

Methods: We retrospectively reviewed the files of patch tested patients with eczema and occupation as construction workers in our Contact Dermatitis Clinic.

Results: One hundred and ninety-one construction workers initially reported contact dermatitis. One hundred and thirty-eight among them had occupation relevant allergic contact dermatitis (ACD) or irritant contact dermatitis (ICD). All subjects were men. After being patch tested, 98 (71.0%) were diagnosed with ACD and 40 with ICD. Median duration of occupation till onset of ACD was 2 years (interquartile range/IQR 0.8 - 7). The hands (73.5%) were the most common location for ACD, followed by the trunk (39.8%), the legs (38.8%) and the face (11.2%). 74.6% of patients had lesions affecting multiple body sites. Potassium dichromate (67%) was the most frequent allergen, followed by thiuram mix (37.4%) and cobalt chloride (31.8%). Sensitization to epoxy resins was lower (12.1%).

Conclusions: The sensitization pattern of Greek construction workers does not follow the trends in Central or Northern Europe, sharing attributes with less industrialized countries. This article is protected by copyright. All rights reserved.
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http://dx.doi.org/10.1111/cod.13970DOI Listing
September 2021

Improvement in Hidradenitis Suppurativa and quality of life in patients treated with adalimumab: Real-world results from the HARMONY Study.

J Eur Acad Dermatol Venereol 2021 Jul 28. Epub 2021 Jul 28.

AbbVie Biopharmaceuticals Ltd, Hod Hasharon, Israel.

Background: Hidradenitis suppurativa (HS), a chronic, recurrent, debilitating skin disease, is characterized by painful, inflammatory, subcutaneous lesions of the axilla, inguinal and anogenital regions. Overall prevalence of HS is ˜1%, and the impact of disease on patient quality of life (QoL) and healthcare resource utilization (HRU) is high.

Objectives: To estimate the real-world effectiveness of adalimumab (Humira®) treatment in patients with moderate-to-severe HS on disease severity, pain, QoL, work productivity and HRU.

Methods: HARMONY (Effectiveness of Adalimumab in Moderate to Severe HidrAdenitis SuppuRativa Patients - a Multi-cOuNtry studY in Real Life Setting) is a multicentre, postmarketing observational study in adult patients with moderate-to-severe HS. Disease severity and QoL parameters were evaluated using validated measures at 12-week intervals over 52 weeks of treatment. The primary endpoint was the proportion of patients achieving a Hidradenitis Suppurativa Clinical Response (HiSCR: ≥50% reduction in abscess and inflammatory nodule count, with no increase in abscess and draining fistula counts relative to baseline) at 12 weeks. Secondary endpoints were HiSCR at 24, 36 and 52 weeks and changes in QoL parameters and work productivity assessments. Analyses were conducted using as-observed data.

Results: The proportion of patients reaching the primary HiSCR endpoint was 70.2% (n = 132/188 enrolled) and remained ≥70% until study completion. There were statistically significant (P < 0.0001) reductions in worst and average skin pain. All of the QoL measures evaluated improved significantly (P < 0.0001) by 12 weeks of adalimumab treatment, as did work productivity assessments (P < 0.05), and there was a ˜50% decrease in HRU between baseline and week 52. Adalimumab was well tolerated.

Conclusions: In this real-world setting, adalimumab treatment of moderate-to-severe HS resulted in decreased disease severity and improvements in QoL and productivity. Response to adalimumab was rapid (within 12 weeks) and sustained (52 weeks). No unexpected safety signals were reported.
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http://dx.doi.org/10.1111/jdv.17551DOI Listing
July 2021

Novel Insights for Patients with Multiple Basal Cell Carcinomas and Tumors at High-Risk for Recurrence: Risk Factors, Clinical Morphology, and Dermatoscopy.

Cancers (Basel) 2021 Jun 27;13(13). Epub 2021 Jun 27.

2nd Department of Dermatology-Venereology, "Attikon" General University Hospital, Medical School, National and Kapodistrian University of Athens, 12462 Athens, Greece.

Introduction: Basal cell carcinoma (BCC) quite frequently presents as multiple tumors in individual patients. Neoplasm's risk factors for local recurrence have a critical impact on therapeutic management.

Objective: To detect risk factors for multiple BCCs (mBCC) in individual patients and to describe clinical and dermatoscopic features of low- and high-risk tumors.

Materials & Methods: Our study included 225 patients with 304 surgically excised primary BCCs. All patients' medical history and demographics were recorded. Clinical and dermatoscopic images of BCCs were evaluated for predefined criteria and statistical analyses were performed.

Results: Grade II-III sunburns before adulthood (OR 2.146, = 0.031) and a personal history of BCC (OR 3.403, < 0.001) were the major predisposing factors for mBCC. Clinically obvious white color (OR 3.168, < 0.001) and dermatoscopic detection of white shiny lines (OR 2.085, = 0.025) represented strongly prognostic variables of high-risk BCC. Similarly, extensive clinico-dermatoscopic ulceration (up to 9.2-fold) and nodular morphology (3.6-fold) raise the possibility for high-risk BCC. On the contrary, dermatoscopic evidence of blue-black coloration had a negative prognostic value for high-risk neoplasms (light OR 0.269, < 0.001/partial OR 0.198, = 0.001).

Conclusions: Profiling of mBCC patients and a thorough knowledge of high-risk tumors' clinico-dermatoscopic morphology could provide physicians with important information towards prevention of this neoplasm.
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http://dx.doi.org/10.3390/cancers13133208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8269292PMC
June 2021

Diagnostic and management challenges of erosive pustular dermatosis of the scalp: a retrospective study in Greek population.

J Eur Acad Dermatol Venereol 2021 Jun 18. Epub 2021 Jun 18.

Second Dermatology Department, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece.

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http://dx.doi.org/10.1111/jdv.17455DOI Listing
June 2021

Efficacy and tolerability of long-pulse Alexandrite laser hair removal for hidradenitis suppurativa.

Eur J Dermatol 2021 Jun 8. Epub 2021 Jun 8.

Dermatology Department, Paul Sabatier University, University Hospital of Toulouse, Toulouse, France.

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http://dx.doi.org/10.1684/ejd.2021.4061DOI Listing
June 2021
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