Publications by authors named "A K Yadav"

1,914 Publications

  • Page 1 of 1

Wilms tumor with Mulibrey Nanism: A case report and review of literature.

Cancer Rep (Hoboken) 2021 Jul 26:e1512. Epub 2021 Jul 26.

Pediatric Hematology Oncology and Bone Marrow Transplant Unit, Cancer Institute, Medanta The Medicity Hospital, Gurgaon, Haryana, India.

Background: Mulibrey-Nanism (Muscle-liver-brain-eye Nanism = dwarfism; MUL) is a rare genetic syndrome. The underlying TRIM37 mutation predisposes these children to develop tumors frequently. In the largest published series of MUL, 8% patients were reported to develop Wilms tumor (WT). The published literature lacks data regarding the best treatment protocol and outcome of this cohort of children with WT and MUL. We report here a 2-year-old boy with WT and MUL and present a review of literature on WT in MUL.

Case: Our patient had associated cardiac problems of atrial septal defect, atrial flutter and an episode of sudden cardiac arrest. We managed him successfully with chemotherapy, surgery and multi-speciality care. He is alive and in remission at follow-up of 6 months.

Conclusion: A total of 14 cases (including present case) of WT have been reported in MUL and treatment details were available for six cases. They were managed primarily with surgery, chemotherapy with/without radiotherapy, and all achieved remission. The outcome data is available only for two cases, one has been followed up till 15 years post treatment for WT and other is our patient.
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http://dx.doi.org/10.1002/cnr2.1512DOI Listing
July 2021

Dengue virus transmission from donor to recipient during haploidentical stem cell transplantation.

IDCases 2021 7;25:e01220. Epub 2021 Jul 7.

Pediatric Hematology Oncology and Bone Marrow Transplant Unit, Cancer Institute, Medanta The Medicity Hospital, Gurgaon, Haryana, 122001, India.

Dengue fever is endemic in tropical and subtropical countries. Dengue virus transmission through hematopoietic stem cells is very rare and just two such cases have been reported previously. We report here only third case of dengue virus transmission in a 2-year-old child with thalassemia major who underwent hematopoietic stem cell transplant (HSCT) from a haploidentical related donor. One week after HSCT, the recipient developed fever, pancytopenia and signs of capillary leak. On day 10, his dengue NS1 antigen test was positive which confirmed diagnosis of dengue fever. Donor also had fever few days prior to stem cell donation which was later diagnosed to be due to dengue fever. Child had a severe clinical course of dengue leading to primary graft failure. However, he had autologous recovery of his own bone marrow and is alive and well on day+200 post HSCT. Our report highlights the transmission of dengue virus from donor to recipient through hematopoietic stem cell graft although rare but possible. We suggest that in tropical and subtropical countries where dengue is endemic, hematopoietic stem cell donors should be screened for it.
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http://dx.doi.org/10.1016/j.idcr.2021.e01220DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8282947PMC
July 2021

Gut microbiota-derived metabolites in CRC progression and causation.

J Cancer Res Clin Oncol 2021 Jul 17. Epub 2021 Jul 17.

Gene Regulation Laboratory, National Institute of Immunology, New Delhi, 110067, India.

Background: Based on recent research reports, dysbiosis and improper concentrations of microbial metabolites in the gut may result into the carcinogenesis of colorectal cancer. Recent advancement also highlights the involvement of bacteria and their secreted metabolites in the cancer causation. Gut microbial metabolites are functional output of the host-microbiota interactions and produced by anaerobic fermentation of food components in the diet. They contribute to influence variety of biological mechanisms including inflammation, cell signaling, cell-cycle disruption which are majorly disrupted in carcinogenic activities.

Purpose: In this review, we intend to discuss recent updates and possible molecular mechanisms to provide the role of bacterial metabolites, gut bacteria and diet in the colorectal carcinogenesis. Recent evidences have proposed the role of bacteria, such as Fusobacterium nucleaturm, Streptococcus bovis, Helicobacter pylori, Bacteroides fragilis and Clostridium septicum, in the carcinogenesis of CRC. Metagenomic study confirmed that these bacteria are in increased abundance in CRC patient as compared to healthy individuals and can cause inflammation and DNA damage which can lead to development of cancer. These bacteria produce metabolites, such as secondary bile salts from primary bile salts, hydrogen sulfide, trimethylamine-N-oxide (TMAO), which are likely to promote inflammation and subsequently cancer development.

Conclusion: Recent studies suggest that gut microbiota-derived metabolites have a role in CRC progression and causation and hence, could be implicated in CRC diagnosis, prognosis and therapy.
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http://dx.doi.org/10.1007/s00432-021-03729-wDOI Listing
July 2021

Unusual sighting in the bone marrow.

Int J Lab Hematol 2021 Jul 16. Epub 2021 Jul 16.

Department of Laboratory Medicine, Hematology Section, PD Hinduja Hospital and Medical Research Centre, Mahim, India.

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http://dx.doi.org/10.1111/ijlh.13661DOI Listing
July 2021

Epidemiological factors influencing gender preference among mothers attending under-five immunization clinic: A cross-sectional comparative study.

J Educ Health Promot 2021 31;10(1):190. Epub 2021 May 31.

Department of Community Medicine, Seth G.S. Medical College and KEM Hospital, Mumbai, Maharashtra, India.

Background: Sex ratio is an important social indicator measuring the status and equality of female in society. The falling sex ratio of our country is a demographic disaster that is waiting to happen and is a matter of grave concern. Perception of gender by mothers or families has long-term implications on how children are nurtured during their lives. This study was done to understand mother's preference for the gender of the child and their concerns about the same.

Materials And Methods: An observational cross-sectional study was carried out using a semi-structured questionnaire. Two hundred and thirty-four mothers were interviewed. Frequencies and percentages were calculated. Pearson's Chi-square test was used to check the significance of the association.

Results: Study results depict that 26.47% of the mothers who were already having a male child still preferred son. Preference for son was 24.52% and 48.61% among earning mothers and nonearning mothers, respectively. Out of 206 mothers said that they would prefer male child. Reasons cited were as follows: sons carry family name forward (30.6%), having daughters leads to increased expenditure (20.9%), daughters are subjected to different problem in their lifetime mainly violence (11.7%), and sons supported their parents in old age (10.7%).

Conclusion: Preference for male child was found to be equally prevalent in both urban and rural areas. Mothers should be educated about the effect of declining sex ratio along with financial capacity building of women and providing social security to senior citizens which was the main reason for son preference. The impact of gender imbalance on individuals, families, and on society has to be emphasized at every possible point of contact with health-care delivery system.
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http://dx.doi.org/10.4103/jehp.jehp_1219_20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8249987PMC
May 2021
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