Publications by authors named "A J Heinrichs"

180 Publications

Erratum zu: Untersuchung standardisierter Anamnesefragebögen zur Diagnostik und Differenzierung von obstruktiven und klaffenden Tubenfunktionsstörungen.

HNO 2021 Aug;69(Suppl 2):97

Klinik für Hals-Nasen-Ohrenheilkunde, Kopf- und Halschirurgie "Otto Körner", Universitätsmedizin Rostock, Doberaner Straße 137-139, 18057, Rostock, Deutschland.

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http://dx.doi.org/10.1007/s00106-021-01083-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8397675PMC
August 2021

Starch-protein interaction in the rumen of weaned dairy calves.

J Dairy Sci 2021 May 6;104(5):5445-5456. Epub 2021 Mar 6.

Department of Animal Science, The Pennsylvania State University, University Park 16802. Electronic address:

The objectives of this study were to investigate the effect of starch and protein interaction on rumen environment, in situ digestion, and total-tract digestibility of nutrients in weaned dairy calves between 8 and 16 wk of age. Sixteen rumen-cannulated calves were randomly divided into 4 dietary treatment groups with 4 calves fed in each treatment. The treatment diets had 2 levels of starch [18%, low starch (LS), or 38%, high starch (HS)] and 2 levels of protein [16%, low protein (LP), or 22%, high protein (HP)] on a dry matter (DM) basis in calf grower: (1) LPLS, (2) LPHS, (3) HPLS, and (4) HPHS. Calves were fed for ad libitum intake (95% assigned grower and 5% grass hay), and refusals were collected weekly. Total-tract digestibility collection and in situ digestibility procedures were performed for each calf at 11 and 15 wk. Samples for in situ digestibility, grass hay (GH), soybean hulls (SBH), wheat middlings (WM), ground corn (GrC), and soybean meal (SBM) were incubated for 9 and 24 h. There was no starch and protein interaction on total-tract digestibility of calves. Total-tract DM, neutral detergent fiber (NDF) and acid detergent fiber (ADF) digestibility, and feed efficiency were affected by both protein and starch inclusion level in calf diet. Total-tract starch digestibility was lower for LS diets. Dry matter digestibility and feed efficiency were greater in calves fed HP and HS diets compared with calves fed LP and LS diets, respectively. Fiber digestibility (NDF and ADF) was less in calves fed HS diets compared with calves fed LS diets but was greater in calves fed HP diets compared with calves fed LP diets. Level of protein did not affect in situ DM and NDF disappearance of GH, but HP increased in situ DM and NDF disappearance of SBH. High-starch diets decreased DM and NDF disappearance of both GH and SBH. At 20 h after feeding, ruminal pH was 0.51 unit higher in calves fed HPHS compared with calves fed LPHS. Total ruminal VFA and proportion of propionate was greater with HS versus LS, whereas proportion of acetate was greater with LS versus HS. The DM disappearance of SBM and WM and NDF disappearance of WM was greater for calves fed HPHS compared with calves fed LPHS at 11 wk of age. In our study, when HP was fed with HS, rumen pH, in situ digestion of WM and SBM, and total-tract digestion of DM, NDF, and ADF increased. This provides evidence for starch-protein interaction in the rumen of recently weaned dairy calves. Improvements in total-tract and in situ digestibility suggest that both protein and starch levels are important for 8- to 16-wk-old calves.
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http://dx.doi.org/10.3168/jds.2020-19990DOI Listing
May 2021

Rapid redesign and implementation of new preclinic and clinic scheduled model during COVID-19.

J Dent Educ 2021 Feb 26. Epub 2021 Feb 26.

College of Dentistry, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.

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http://dx.doi.org/10.1002/jdd.12583DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8014326PMC
February 2021

HPV DNA/RNA detection in various oral and oropharyngeal biomaterials identifies active HPV infections also in non-neoplastic tonsils.

Transl Oncol 2021 Feb 24;14(2):101002. Epub 2020 Dec 24.

Department of Otorhinolaryngology, Head and Neck Surgery, Christian-Albrechts-University Kiel, Arnold-Heller-Str. 3, Building 27, D24105 Kiel, Germany. Electronic address:

Previous studies describe a correlation between HPV-positivity and non-smoking in TSCC; p16-expression as surrogate-marker for HPV-DNA/RNA-positivity is discussed controversially. In the present study, these parameters are assessed prospectively. HPV-status of sputum and tonsillar-swabs was analyzed to determine their validity as surrogate-marker for tissue-HPV-status. TSCC- (n = 52) and non-neoplastic tonsillar tissue (n = 163) were analyzed. HPV-DNA- and HPV-RNA-status of total sputum, cellular fraction and supernatants, tonsillar-swabs and -tissue was determined by (RT)-PCR. Immunohistochemistry determined p16-expression. 23/163 (14.2%) non-neoplastic tonsils were HPV-DNA-positive; five patients (3 HPV16, 2 HPV11) had active HPV-infections (HPV-RNA-positive), in all biomaterials. 140/163 (85.9%) patients were either HPV-DNA-positive or HPV-DNA-negative in all samples. 21/52 (40.4%) TSCC-tonsils were HPV-DNA-positive; 17 patients were HPV-RNA-positive (14 HPV16; 4 HPV18). 40/52 (76.9%) TSCC-patients were congruent in all biomaterials. p16-expression alone would have misclassified the HPV-status of 14/52 (26.2%) TSCC-patients. This prospective study confirms the discrepancy between HPV-status and p16-expression and the significant correlation between non-smoking and HPV-DNA-positivity. HPV-sputum- and/or swab-results do not consistently match tissue-results, possibly having (detrimental) consequences if those were used to assess tissue-HPV-status. In the 5 patients with active HPV infection in the non-neoplasitic tonsils, tonsillectomy likely prevented subsequent development of TSCC.
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http://dx.doi.org/10.1016/j.tranon.2020.101002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7772224PMC
February 2021

Replacing soybean hulls with grass hay on growth, intake, total tract digestibility, and rumen microbial nitrogen production of weaned Holstein dairy calves from 8 to 16 weeks of age.

J Dairy Sci 2021 Feb 11;104(2):1714-1727. Epub 2020 Dec 11.

Department of Animal Science, The Pennsylvania State University, University Park 16802. Electronic address:

The objective of this experiment was to determine the effects of replacing soybean hull (SBH) pellets with grass hay (GH) on growth, intake, total-tract digestibility, and rumen microbial nitrogen production of weaned dairy calves from 8 to 16 wk of age. Holstein calves (n = 16) were randomly assigned to 1 of 4 rations containing, on a dry matter (DM) basis, 76% grower with the remaining 24% being made up of different amounts of SBH pellets and GH [0% GH, 24% SBH (0GH); 8% GH, 16% SBH (8GH); 16% GH, 8% SBH (16GH); and 24% GH, 0% SBH (24GH)]. Calves were weaned at 6 wk, housed individually, and studied from 8 to 16 wk of age. From 8 to 9 wk of age calves were offered a ration consisting of 50% of texturized starter (20% CP and 35% starch), which was offered from 3 d of age, and 50% of their assigned ration. From 9 wk until the end of the study, calves were offered 100% of their assigned ration. Intake and body weight were measured weekly, and frame measurements were taken at the beginning and end of the study. Animal behavior observations were recorded every 5 min over a 24-h period at 10 and 14 wk of age. Total fecal and urine collection was conducted for 4 d consecutively at 11 and 15 wk of age. Feed and feces were evaluated for DM, N, neutral detergent fiber, acid detergent fiber, and starch to determine total-tract digestibility. Feces were evaluated for geometric mean particle length (X) and particle size distribution. Urine was evaluated for N, creatinine, urea, and total purine derivatives to estimate microbial N yield. Calves offered 0GH and 8GH had a 20% increase in intake, average daily gain (1.23, 1.27, 0.89, and 0.71 kg/d for 0GH, 8GH, 16GH, and 24GH, respectively), and feed efficiency compared with 16GH and 24GH. Calves offered 8GH had the greatest levels of neutral detergent fiber and acid detergent fiber digestibility, as well as the greatest estimated microbial N yields. Inclusion of forage increased rumination time (2.75, 6.89, 7.18, and 8.16 h/d for 0GH, 8GH, 16GH, and 24GH, respectively) and decreased fecal X by ~35% compared with calves offered 0GH. In the current study, increasing the replacement of SBH with GH beyond 8% was detrimental to weaned calf performance. These results indicate that when diets containing 8% GH and 16% SBH were fed to recently weaned calves, rumen functionality and feed efficiency were optimized compared with the other GH-SBH combinations.
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http://dx.doi.org/10.3168/jds.2020-18935DOI Listing
February 2021
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