Publications by authors named "A Ibrahim Ulusoy"

77 Publications

COVID-19 Pneumonia or Hypereosinophilic Syndrome?

J Med Cases 2020 Dec 21;11(12):400-402. Epub 2020 Oct 21.

Deparment of Internal Medicine and Hematology, Liv Hospital ULUS, Istanbul, Turkey.

Hypereosinophilic syndromes (HESs) are a group of disorders characterized by pathological proliferation of eosinophils. Diagnostic criteria include eosinophil count of 1,500/mm or higher, presence of organ involvement and exclusion of other causes of eosinophilia for at least 6 months. A 69-year-old male patient was referred to the pandemic clinic with a preliminary diagnosis of coronavirus disease 2019 (COVID-19) with fever and dyspnea. Computed tomography (CT) was compatible with COVID-19, nasopharyngeal swab polymerase chain reaction (PCR) was negative for two times. He had 20,000/mm eosinophilia and retrospective examinations showed that he have had eosinophilia for more than 1 year. Platelet-derived growth factor receptor alpha () resulted positively. After starting parenteral methylprednisolone with a dose of 1 mg/kg, he was discharged with oral maintenance therapy. In outpatient follow-up, it was observed that eosinophilic pneumonia completely regressed. HES may occur with multiple system and organ involvement and findings. In the differential diagnosis of patients presenting with heart failure, pulmonary involvement and eosinophilia, HES must definitely be considered.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.14740/jmc3587DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8040447PMC
December 2020

Comparison of the effectiveness of two treatment modalities for chronic anal fissure: Botox versus sphincterotomy.

Turk J Surg 2020 Sep 28;36(3):264-270. Epub 2020 Sep 28.

Sisli Hamidiye Etfal Training And Research Hospital, General Surgery, Istanbul, Turkey.

Objectives: Anal fissure is a common health problem that affects the quality of life of young patients. The aim of our study was to benchmark results of lateral internal sphincterotomy (LIS) and botulinum toxin injection in the treatment of chronic anal fissure.

Material And Methods: This multi-center, retrospective study used data from 135 chronic anal fissure patients. Patients' demographic features, clinical findings, fissure characteristics, post-defecation pain score, rectal bleeding or pruritus, and treatment satisfaction scores were recorded. Patients' data were collected from the hospital records and patients with all of this data available were called and invited to the hospital for examination.

Results: Seventy-four LIS and 61 botulinum toxin applied patients were included. Symptom duration, hospitalization period, and duration of remission of complaints after the treatment were significantly higher in the LIS group (p<0.001). However, pruritus in anus and relapses were found to be higher in the botulinum toxin group (p=¬ 0.04 and p= 0.043, respectively). Abscess and fistula were observed in one patient's perianal region in the LIS group, and an abscess was observed in one patient in the botulinum toxin group. There was no significant difference in treatment satisfaction rates and postoperative complications.

Conclusion: Botulinum toxin yields satisfying results that are comparable to LIS. Patient selection may help mitigate this disease and allow it to be considered a good alternative option to surgery.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.47717/turkjsurg.2020.4492DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7963312PMC
September 2020

Synapsin Condensates Recruit alpha-Synuclein.

J Mol Biol 2021 Jun 25;433(12):166961. Epub 2021 Mar 25.

Laboratory of Molecular Neuroscience, German Center for Neurodegenerative Diseases (DZNE), 10117 Berlin, Germany. Electronic address:

Neurotransmission relies on the tight spatial and temporal regulation of the synaptic vesicle (SV) cycle. Nerve terminals contain hundreds of SVs that form tight clusters. These clusters represent a distinct liquid phase in which one component of the phase are SVs and the other synapsin 1, a highly abundant synaptic protein. Another major family of disordered proteins at the presynapse includes synucleins, most notably α-synuclein. The precise physiological role of α-synuclein in synaptic physiology remains elusive, albeit its role has been implicated in nearly all steps of the SV cycle. To determine the effect of α-synuclein on the synapsin phase, we employ the reconstitution approach using natively purified SVs from rat brains and the heterologous cell system to generate synapsin condensates. We demonstrate that synapsin condensates recruit α-synuclein, and while enriched into these synapsin condensates, α-synuclein still maintains its high mobility. The presence of SVs enhances the rate of synapsin/α-synuclein condensation, suggesting that SVs act as catalyzers for the formation of synapsin condensates. Notably, at physiological salt and protein concentrations, α-synuclein alone is not able to cluster isolated SVs. Excess of α-synuclein disrupts the kinetics of synapsin/SV condensate formation, indicating that the molar ratio between synapsin and α-synuclein is important in assembling the functional condensates of SVs. Understanding the molecular mechanism of α-synuclein interactions at the nerve terminals is crucial for clarifying the pathogenesis of synucleinopathies, where α-synuclein, synaptic proteins and lipid organelles all accumulate as insoluble intracellular inclusions.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jmb.2021.166961DOI Listing
June 2021

The variability of electric pulp response thresholds in primary molars: a clinical study.

Authors:
M Bulut A T Ulusoy

Eur Arch Paediatr Dent 2021 Feb 22. Epub 2021 Feb 22.

Department of Pediatric Dentistry, Faculty of Dentistry, Ondokuz Mayis Univesity, Samsun, Turkey.

Purpose: The variability of the EPT response threshold is the most important part of accurate diagnosis of pulp status of caries-affected resorbing primary teeth. This study evaluated the mean EPT threshold values and appropriate electrode placement sites for primary molar teeth based on their physiological root resorption levels.

Methods: This study was conducted with 100 primary second molars in 100 children ages 3-12 (mean age: 7.88 years). Teeth were divided into 2 groups according to physiological root resorption levels. EPT response thresholds were recorded at the mesiobuccal cusp, occlusal third, middle third and cervical third of the crown. Data were analyzed according to resorption level using one-way analysis of variance and Duncan tests, with the level of significance set at 0.05.

Results: Mean threshold values at all placement sites were higher in the group with the higher level of physiological root resorption. In terms of placement, the lowest mean EPT threshold values were obtained at the mesiobuccal cusp regardless of resorption level.

Conclusions: According to the study results, higher resorption levels were associated with higher physiologocial threshold values for EPT of primary second molars, with the mesiobuccal site identified as the most appropriate electrode placement site, regardless of resorption level.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1007/s40368-021-00608-3DOI Listing
February 2021

The Relationship Between Serum Angiogenic Factor Levels and Disease Activity in Rheumatoid Arthritis.

Arch Rheumatol 2020 Sep 8;35(3):416-425. Epub 2020 Jan 8.

Department of Biochemistry, Manisa Celal Bayar University Faculty of Medicine, Manisa, Turkey.

Objectives: This study aims to evaluate the relationship between serum angiogenic factor levels and disease activity in patients with rheumatoid arthritis (RA) using both clinical and dynamic wrist magnetic resonance imaging (MRI) data.

Patients And Methods: Simultaneous serum angiogenesis markers [vascular endothelial growth factor (VEGF), angiopoietin-1 (ANG1), ANG2, and tyrosine-protein kinase receptor for angiopoietin (Tie-2)] were studied in 40 patients with RA (13 males, 27 females; mean age 51.1±10.8 years; range, 23 to 69 years) and 20 healthy controls (11 males, 9 females; mean age 47.3±12.8 years; range, 29 to 69 years) and dynamic contrast-enhanced wrist MRI was performed in 40 RA patients and seven controls. Rate of early in 55th second (REE) and Relative enhancement (REt) values were calculated from the signal time curve values obtained from the analysis of images. In clinical assessment, duration of morning stiffness, patient pain assessment [visual analog scale (VAS)], physician and patient global assessments (VAS) were recorded. The number of tender joints and swollen joints were determined. Disease activity score 28 and Ritchie scores were calculated. Health assessment questionnaire was used for functional evaluation. Anti-cyclic citrullinated peptide, rheumatoid factor, erythrocyte sedimentation rate and high sensitive C-reactive protein analyses were performed.

Results: Serum VEGF, REE and REt values were significantly higher in RA patients than healthy controls (p=0.002, p=0.00, p=0.00, respectively). There was no significant correlation between serum angiogenesis markers and clinical parameters or REE and REt (p>0.05). VEGF value correlated positively with disease duration (p=0.024).

Conclusion: Serum VEGF was higher in RA patients. While its level was associated with disease duration, no significant correlation was found with disease activity. As a diagnostic test, dynamic contrast-enhanced MRI was a valuable method for showing disease activity.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.46497/ArchRheumatol.2020.7416DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7788655PMC
September 2020