Publications by authors named "A Hussain"

3,027 Publications

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Willingness of a Multiethnic Immigrant Population to Donate Biospecimens for Research Purposes.

J Immigr Minor Health 2021 Jul 26. Epub 2021 Jul 26.

Department of Pediatrics and Women's Health, University of North Texas Health Science Center, Texas College of Osteopathic Medicine, Fort Worth, TX, USA.

This cross-sectional study explores the willingness to donate biospecimens for research purposes among six refugee communities in North Texas (spanning Myanmar, Central Africa, Somalia, Nepal, Arabic speaking countries, and others). Participants were asked four questions about biospecimen donation: (1) previously asked to donate, (2) ever agreed to donate, (3) willingness to donate for future research, and (4) what samples they would be willing to donate. Most participants (77%) were willing to donate biosamples for medical research; 58% were willing to donate samples. Fewer refugees from Somalia were willing to donate compared to immigrants from Myanmar, Central Africa, and Nepal (p < 0.01). Participants in the older age group (40 + years) were 3.2 times more likely to be willing for donation of biospecimens than the younger ones (OR 3.22, 95% CI 1.22, 8.55). Findings suggest refugees' willingness to participate in biospecimen donation which support intentional inclusion of multicultural populations into medical research.
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http://dx.doi.org/10.1007/s10903-021-01241-4DOI Listing
July 2021

Glycyrrhetinic acid: A Promising Scaffold for the Discovery of Anticancer Agents.

Expert Opin Drug Discov 2021 Jul 23. Epub 2021 Jul 23.

Department of Education, Sukkur IBA University, Sukkur-65200 Sindh, Pakistan.

Introduction: : Oleanane-type pentacyclic triterpenes named glycyrrhetinic acids (GAs) featuring a C-30 carboxylic acid group, are extracted from the licorice (). Numerous biological properties of GA have been reported and have attracted researchers from all over the world in recent years due to the peculiar GA scaffold based semisynthetic cytotoxic effects.

Areas Covered: : This review represents the applications of semisynthetic derivatives of GA for the development of future cancer treatments. Included in the review are important structural features of the semisynthetic GAs crucial for cytotoxic effects.

Expert Opinion: : Numerous semisynthetic GA derivatives illustrated excellent cytotoxic effects towards various cancer cells. Notably the C-(OH) at ring A along with CCOH at ring E as vital structural features, make GA very appealing as a lead scaffold for medicinal chemistry, since these two groups permit the creation of further chemical diversity geared towards improved cytotoxic effects. Furthermore, numerous GA derivatives have been synthesized and indicate that compounds featuring cyanoenone moieties in ring A, or compounds having the amino group or nitrogen comprising heterocycles and hybrids thereof, illustrate more potent cytotoxicity. Furthermore, GA has a great capability to be conjugated with other anticancer molecules to synergistically enhance their combined cytotoxicity.
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http://dx.doi.org/10.1080/17460441.2021.1956901DOI Listing
July 2021

Estimation of polymorphisms in the drug-metabolizing enzyme, cytochrome gene in six major ethnicities of Pakistan.

Bioengineered 2021 Dec;12(1):4442-4451

Faculty of Biological Sciences, Kabul University, Kabul Afghanistan.

Interindividual differences in cytochrome P450 ( 2C19 activity may result in variations in the therapeutic response to drugs metabolized by this enzyme. Differences at gene level may translate into protein level with consequent impairment of the enzyme activity. As a result patients with such genetic differences might experience undesirable effects or no effect at all. The aim of the present study was to find out the prevalence of allelic and genotype frequencies of low activity variants of CYP2C19 genes in healthy individuals from six distinct ethnicities of Pakistan. Blood sample was taken from healthy volunteers following informed consent. Isolation of the DNA was followed by the PCR amplification and restriction fragment length polymorphism. Selected samples were sequenced by Sanger sequencing. The frequency of major alleles was 84.93% for and 91.85% for CYP2C19*3, while minor allele was present at 15.06% for and 8.14% for CYP2C19*3. For , the frequency of *1*1 genotype was 75.80%, *1*2 was 18.27%, and *2*2 was 5.92% whereas for , The frequency of *1*1 genotype was 84.19%, *1*3 was 15.30%, and *3*3 was 0.49% in the Pakistani population. A substantial variation in genotype and allelic frequencies was observed in various ethnicities. Our study demonstrates that a significant Pakistani population has at least one minor allele, which indicates a large number of patients potentially being affected by these variations. Especially, a significant genotype frequency of PM suggests implication for the treatment response and severity/frequency of adverse effects in patients receiving drugs metabolized by CYP2C19.
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http://dx.doi.org/10.1080/21655979.2021.1955809DOI Listing
December 2021

Efficacy of rhizobacterial exopolysaccharides in improving plant growth, physiology, and soil properties.

Environ Monit Assess 2021 Jul 24;193(8):515. Epub 2021 Jul 24.

Department of Soil Sciencce, The Islamia University of Bahawalpur, Bahawalpur, 63100, Pakistan.

The current study investigated the influence of exopolysaccharides (EPSs) producing plant growth-promoting rhizobacteria (PGPR) on the growth, physiology, and soil properties. The pre-isolated and compatible EPS producing PGPR strains were first screened based on improvement in soil aggregates in an incubation study. The screened strains (Rhizobium phaseoli strain Mn-6, Pseudomonas bathysetes strain LB, and unidentified strain R) were then employed in pot study for assessing improvements in maize growth, physiology, and soil properties. Eight treatments including T = control, T = Mn-6, T = R, T = LB, T = Mn-6 + R, T = Mn-6 + LB, T = R + LB, and T = Mn-6 + R + LB were applied in completely randomized design (CRD) hexa replicated (half for root and half for soil, and yield attributes). The results depicted that among various treatments, the application of PGPR strain Mn-6 increased plant height, root length, root fresh and dry weight, root length density, SPAD value, leaf areas index, photosynthesis rate, transpiration, and stomatal conductance by 24, 79, 72, 90, 49, 35, 23, 21, 75, and 77%, respectively, compared with non-inoculated treatment. Similarly, significant improvement in maize yield and soil physical properties was also observed in response to the application of EPS-producing PGPR. Therefore, it is concluded that the application of EPS producing PGPR is an effective strategy to improve plant growth, physiology, yield, and soil physical properties. Moreover, EPS-producing PGPR should be exploited in field studies for their potential in improving plant growth and soil properties.
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http://dx.doi.org/10.1007/s10661-021-09286-6DOI Listing
July 2021

Evaluation of uptake of eight metals by Sorghum bicolor grown in arable soil combined with sewage sludge based on prediction models.

Environ Monit Assess 2021 Jul 23;193(8):510. Epub 2021 Jul 23.

Biology Department, College of Science, King Khalid University, Abha, 61321, Saudi Arabia.

Prediction models were developed to estimate the extent to which aluminium, chromium, copper, iron, manganese, nickel, lead, and zinc were absorbed in the grains, leaves, stems, and roots of Sorghum bicolor cultivated in soil with various amendment rate of sewage sludge (0, 10, 20, 30, 40, and 50 g/kg) under greenhouse conditions. It was found that, aside from lead, all the examined metals occurred in significantly higher content in the roots compared to aerial tissues. Furthermore, the r-values were significantly negative between the bioconcentration factors of all metals, apart from aluminium and lead, and soil pH, whereas they were significantly positive between the bioconcentration factors, apart from lead, and soil organic matter content (OM). The r-values were typically significantly positive between the levels of all eight metals in the investigated tissues and in the soil. Moreover, the content of all the eight metals in the tissues exhibited a significant negative r-value with soil pH but a significant positive r-value with soil OM. The eight metal contents in the tissues given by the prediction models were quite similar to the real values, suggesting that the created models performed well, as shown by t-tests. It was thus concluded that prediction models were a viable option for evaluating how safe it was to grow S. bicolor in soils with sewage sludge content and at the same time for keeping track of possible human health hazards.
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http://dx.doi.org/10.1007/s10661-021-09320-7DOI Listing
July 2021
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