Publications by authors named "A Heather Eliassen"

268 Publications

Healthful and unhealthful plant-based diets and risk of breast cancer in U.S. women: results from the Nurses' Health Studies.

Cancer Epidemiol Biomarkers Prev 2021 Jul 21. Epub 2021 Jul 21.

Channing Division of Network Medicine, Brigham and Women's Hospital.

Background Plant-based diets have been associated with lower risk of various diseases, including type 2 diabetes, cardiovascular disease and other cardiometabolic risk factors. However, the association between plant-based diet quality and breast cancer remains unclear. Methods We prospectively followed 76,690 women from the Nurses' Health Study (NHS,1984-2016) and 93,295 women from the Nurses' Health Study II (NHSII,1991-2017). Adherence to an overall plant-based diet index (PDI), a healthful PDI (hPDI) and an unhealthful PDI (uPDI) was assessed using previously developed indices. Cox proportional hazards models were used to estimate HR and 95% CIs for incident invasive breast cancer. Results Over 4,841,083 person-years of follow-up, we documented 12,482 incident invasive breast cancer cases. Women with greater adherence to PDI and hPDI were at modestly lower risk of breast cancer [(HR Q5vsQ1 0.89; 95% CI 0.84, 0.95); (HR Q5vsQ1 0.89; 95% CI 0.83, 0.94)]. We observed significant heterogeneity by estrogen receptor (ER) status, with the strongest inverse association between hPDI and breast cancer observed with ER-negative tumors [HR Q5vsQ1 0.77; 95% CI 0.65, 0.90; p-trend<0.01]. We also found an inverse association between extreme quintiles of healthy plant foods and ER-negative breast cancer [HR 0.74; 95% CI 0.61, 0.88; p-trend<0.01]. Conclusions This study provides evidence that adherence to a healthful plant-based diet may reduce the risk of breast cancer, especially those that are more likely to be aggressive tumors. Impact This is the first prospective study investigating the relation between healthful and unhealthful plant-based dietary indices and risk of total and subtype-specific breast cancer.
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http://dx.doi.org/10.1158/1055-9965.EPI-21-0352DOI Listing
July 2021

Reproductive and hormonal factors and risk of incident rosacea among US White women.

J Am Acad Dermatol 2021 Jul 15. Epub 2021 Jul 15.

Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Cancer Epidemiology, Peking University Cancer Hospital & Institute, Beijing, People's Republic of China; Department of Dermatology, Warren Alpert Medical School, Brown University, Providence, Rhode Island; Department of Epidemiology, School of Public Health, Brown University, Providence, Rhode Island. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2021.06.865DOI Listing
July 2021

Periodontal Disease and Breast Cancer Risk: Results from the Nurses' Health Study.

Cancer Epidemiol Biomarkers Prev 2021 Jun 29. Epub 2021 Jun 29.

Department of Epidemiology and Environmental Health, School of Public Health and Health Professions, University at Buffalo, State University of New York, Buffalo, New York.

Background: While periodontal disease has been linked to increased cancer risk, studies regarding an association with breast cancer are limited.

Methods: We examined the relationship between self-reported diagnosis of periodontal bone loss and incidence of breast cancer in a large, prospective cohort study, the Nurses' Health Study (1998-2014). We calculated HRs using Cox proportional hazards modeling, adjusting for risk factors common to both periodontal disease and breast cancer.

Results: During 1,023,647 person-years of follow-up, 5,110 of breast cancer cases were reported. We observed no association between periodontal disease and overall breast cancer risk (HR, 1.02; 95% confidence interval: 0.94-1.10); the association was not modified by smoking status, or other breast cancer risk factors or by breast tumor subtypes.

Conclusions: We did not observe any association between periodontal disease and breast cancer risk.

Impact: Given inconsistent findings in the literature, further research with standardized clinical measures of periodontitis is warranted.
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http://dx.doi.org/10.1158/1055-9965.EPI-21-0257DOI Listing
June 2021

Breast cancer risk factors and circulating anti-Müllerian hormone concentration in healthy premenopausal women.

J Clin Endocrinol Metab 2021 Jun 22. Epub 2021 Jun 22.

Department of Population Health, New York University School of Medicine, New York, NY.

Context: In a previous study we reported that anti-Müllerian hormone (AMH), a marker of ovarian reserve, is positively associated with breast cancer risk, consistent with other studies.

Objective: Assess whether risk factors for breast cancer are correlates of AMH concentration.

Design: Cross-sectional.

Participants: 3831 healthy premenopausal women (aged 21-57, 87% aged 35-49).

Setting: Ten cohort studies, general population.

Results: Adjusting for age and cohort, we observed positive associations of AMH with age at menarche (p<0.0001) and parity (p=0.0008), and an inverse association with hysterectomy/partial oophorectomy (p=0.0008). Compared to women of normal weight (BMI 18.5-24.9 kg/m 2, AMH was lower (relative geometric mean difference 27%, p<0.0001) among women who were obese (BMI>30). Current oral contraceptive use and current/former smoking were associated with lower AMH concentration than never use (40% and 12% lower, respectively, p<0.0001). We observed higher AMH concentrations among women who had had a benign breast biopsy (15% higher, p=0.03), a surrogate for benign breast disease, an association that has not been reported. In analyses stratified by age (<40/≥40), associations of AMH with BMI and oral contraceptives were similar in younger and older women, while associations with the other factors (menarche, parity, hysterectomy/partial oophorectomy, smoking, and benign breast biopsy) were limited to women ≥40 (p-interaction<0.05).

Conclusion: This is the largest study of AMH and breast cancer risk factors among women from the general population (not presenting with infertility), and suggests that most of the associations are limited to women over 40, who are approaching menopause and whose AMH concentration is declining.
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http://dx.doi.org/10.1210/clinem/dgab461DOI Listing
June 2021

Functional annotation of the 2q35 breast cancer risk locus implicates a structural variant in influencing activity of a long-range enhancer element.

Am J Hum Genet 2021 Jul 18;108(7):1190-1203. Epub 2021 Jun 18.

Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany.

A combination of genetic and functional approaches has identified three independent breast cancer risk loci at 2q35. A recent fine-scale mapping analysis to refine these associations resulted in 1 (signal 1), 5 (signal 2), and 42 (signal 3) credible causal variants at these loci. We used publicly available in silico DNase I and ChIP-seq data with in vitro reporter gene and CRISPR assays to annotate signals 2 and 3. We identified putative regulatory elements that enhanced cell-type-specific transcription from the IGFBP5 promoter at both signals (30- to 40-fold increased expression by the putative regulatory element at signal 2, 2- to 3-fold by the putative regulatory element at signal 3). We further identified one of the five credible causal variants at signal 2, a 1.4 kb deletion (esv3594306), as the likely causal variant; the deletion allele of this variant was associated with an average additional increase in IGFBP5 expression of 1.3-fold (MCF-7) and 2.2-fold (T-47D). We propose a model in which the deletion allele of esv3594306 juxtaposes two transcription factor binding regions (annotated by estrogen receptor alpha ChIP-seq peaks) to generate a single extended regulatory element. This regulatory element increases cell-type-specific expression of the tumor suppressor gene IGFBP5 and, thereby, reduces risk of estrogen receptor-positive breast cancer (odds ratio = 0.77, 95% CI 0.74-0.81, p = 3.1 × 10).
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http://dx.doi.org/10.1016/j.ajhg.2021.05.013DOI Listing
July 2021
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