Publications by authors named "A Harrison"

1,927 Publications

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Development of Herpes Zoster Ophthalmicus in an Immunocompetent Pediatric Patient Following Facial Trauma.

Ophthalmic Plast Reconstr Surg 2021 Jul 27. Epub 2021 Jul 27.

Department of Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, Minnesota, U.S.A. Department of Otolaryngology and Head and Neck Surgery, University of Minnesota, Minneapolis, Minnesota, U.S.A.

Herpes zoster ophthalmicus (HZO) is a neuro-oculo-dermic infection caused by reactivation of latent varicella zoster virus in the dorsal root ganglia of the ophthalmic division of the trigeminal nerve. Although a rare diagnosis in an otherwise healthy, vaccinated pediatric patient, this entity may occur with increasing frequency among those with preceding trauma, particularly in the month prior to presentation. Herein, we highlight a case of HZO in a vaccinated, immunocompetent adolescent in the setting of recent facial trauma.
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http://dx.doi.org/10.1097/IOP.0000000000001970DOI Listing
July 2021

Mental health and quality of life for people with rheumatoid arthritis or ankylosing spondylitis in Aotearoa New Zealand following the COVID-19 national lockdown.

Rheumatol Int 2021 Jul 23. Epub 2021 Jul 23.

Department of Medicine, Dunedin School of Medicine, University of Otago, Otago, New Zealand.

The aim of this study was to investigate the effects of lockdown on the mental health (anxiety and depression) and quality of life (QOL) of people with rheumatoid arthritis (RA) and ankylosing spondylitis (AS) in the context of the COVID-19 pandemic and public health measures instituted at a national level by the New Zealand Government. The present cohort was 104 individuals with RA (73.1%) and AS (26.9%) who had previously completed surveys for the Patient Opinion Real-Time Anonymous Liaison (PORTAL) project in 2018. Participants completed an online survey between July and September 2020 assessing their experiences over the first national COVID-19 lockdown in New Zealand (March-May, 2020). Fear of SARS-CoV-2 infection, baseline anxiety, and being younger in age were all predictors of participants' current anxiety levels. Current QOL scores were significantly lower than prior to lockdown and were predicted by baseline QOL and current depression. No variables predicted current depression other than baseline levels. The COVID-19 pandemic appears to have had an impact on QOL and anxiety levels, but not depression for people with RA and AS in New Zealand. These novel findings imply that appropriate screening of mental health issues should be included in planning within the ongoing COVID-19 pandemic and for future pandemics to optimise the wellbeing of people with RA and AS.
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http://dx.doi.org/10.1007/s00296-021-04952-xDOI Listing
July 2021

Amplicon and Metagenomic Analysis of Middle East Respiratory Syndrome (MERS) Coronavirus and the Microbiome in Patients with Severe MERS.

mSphere 2021 Jul 21:e0021921. Epub 2021 Jul 21.

Institute for Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, United Kingdom.

Middle East respiratory syndrome coronavirus (MERS-CoV) is a zoonotic infection that emerged in the Middle East in 2012. Symptoms range from mild to severe and include both respiratory and gastrointestinal illnesses. The virus is mainly present in camel populations with occasional zoonotic spill over into humans. The severity of infection in humans is influenced by numerous factors, and similar to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), underlying health complications can play a major role. Currently, MERS-CoV and SARS-CoV-2 are coincident in the Middle East and thus a rapid way of sequencing MERS-CoV to derive genotype information for molecular epidemiology is needed. Additionally, complicating factors in MERS-CoV infections are coinfections that require clinical management. The ability to rapidly characterize these infections would be advantageous. To rapidly sequence MERS-CoV, an amplicon-based approach was developed and coupled to Oxford Nanopore long read length sequencing. This and a metagenomic approach were evaluated with clinical samples from patients with MERS. The data illustrated that whole-genome or near-whole-genome information on MERS-CoV could be rapidly obtained. This approach provided data on both consensus genomes and the presence of minor variants, including deletion mutants. The metagenomic analysis provided information of the background microbiome. The advantage of this approach is that insertions and deletions can be identified, which are the major drivers of genotype change in coronaviruses. Middle East respiratory syndrome coronavirus (MERS-CoV) emerged in late 2012 in Saudi Arabia. The virus is a serious threat to people not only in the Middle East but also in the world and has been detected in over 27 countries. MERS-CoV is spreading in the Middle East and neighboring countries, and approximately 35% of reported patients with this virus have died. This is the most severe coronavirus infection so far described. Saudi Arabia is a destination for many millions of people in the world who visit for religious purposes (Umrah and Hajj), and so it is a very vulnerable area, which imposes unique challenges for effective control of this epidemic. The significance of our study is that clinical samples from patients with MERS were used for rapid in-depth sequencing and metagenomic analysis using long read length sequencing.
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http://dx.doi.org/10.1128/mSphere.00219-21DOI Listing
July 2021

Challenges to conducting adolescent HIV prevention services research with court-involved youth.

Child Youth Serv Rev 2017 Dec 31;83:201-208. Epub 2017 Oct 31.

Rhode Island Hospital Department of Psychiatry, United States.

Multiple assessment studies demonstrate that juvenile offenders are at increased risk for contracting HIV and other STIs relative to their non-offending counterparts. Such data are used to support the implementation of adolescent HIV prevention interventions within the juvenile justice system. Despite the compelling data related to high rates of unprotected sexual activity, pregnancy, STIs, substance use and psychiatric symptoms, there are very few empirically supported HIV prevention interventions for this adolescent subgroup. Using our experience conducting HIV prevention research studies with court-involved, non-incarcerated (CINI) youth we identify salient and unique challenges to consider when conducting HIV prevention intervention research with this population. Obstacles to consider include lack of "buy-in" and engagement from justice staff and families about the need for youth sexual health promotion and HIV prevention services and logistical barriers (time, transportation, space) related to conducting intervention research with a community-based sample of justice-involved youth. We consider these various challenges and provide recommendations for researchers on how to overcome barriers to continue to develop evidence-based HIV prevention services for communities of youth in need.
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http://dx.doi.org/10.1016/j.childyouth.2017.10.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8281964PMC
December 2017

Growth rates for freshwater ferromanganese concretions indicate regional climate change in eastern Canada at the Northgrippian-Meghalayan boundary.

Holocene 2021 Aug 27;31(8):1250-1263. Epub 2021 Apr 27.

Chinese Academy of Geological Sciences, Beijing.

The existence of freshwater ferromanganese concretions has been known for decades, but we are not aware of a generally accepted explanation for their formation, and there has been little research into their potential use as records of Holocene climate and paleohydrology. A conceptual model is presented to describe the environmental and geochemical processes which result in the formation and growth of freshwater ferromanganese concretions. In order to evaluate their potential as historical geochemical records, a concretion from Magaguadavic Lake, New Brunswick, Canada is the focus of a detailed geochronological and geochemical investigation. The radiocarbon data provide a coherent growth curve and a maximum age for the concretion of 8448 ± 43 years, consistent with the establishment of Magaguadavic Lake as a stable post-glacial lacustrine system. The data suggest accretion rates of 1.5 and 3.4 mm per 1000 years during the Northgrippian and Meghalayan stages of the Holocene, respectively. The abrupt change in growth rate observed at the stage boundary may be an indicator of Holocene climate change. These features are consistent with inferences from previous research that warmer climate in the Northgrippian led to eutrophication in some lakes in eastern North America. The results confirm that freshwater Fe-Mn concretions may yield important information about past climatic and environmental conditions.
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http://dx.doi.org/10.1177/09596836211011652DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8243233PMC
August 2021
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