Publications by authors named "A E Nikolaev"

680 Publications

[ACTUAL STRATEGY OF TREATMENT VARICOSE VEINS RECURRENCE AFTER ENDOVENOUS INTERVENTIONS].

Georgian Med News 2021 Apr(313):26-33

4Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Russian Federation.

The aim of the study is to substantiate the surgical treatment tactics of recurrence varicose veins after endovenous interventions. Early and long-term results of the treatment, quality of life of patients with recurrence of varicose veins were studied. Among the admitted patients, there were 55 (65.5%) women and 29 (34.5%) men, the age of patients varied from 19 to 76 years. Of these, 9 patients underwent crossectomy, endovenous laser coagulation - 22, various stripping options - 4, echosclerotherapy - 20, intraoperative catheter sclerobliteration - 1, ligation of perforating veins - 28 patients. The choice of the treatment method depends on the data of duplex angioscanning, the source of recurrence, the diameter and length of the varicose veins. In the early postoperative period 18 (22.6%) patients had complications and side effects. Most often hyperpigmentation and neurological disorders developed, which were observed in 8 (9.5%) and 7 (8.3%) cases. 2 (2.4%) patients had a slightly painful dense cord after endovenous laser coagulation. 1 (1.2%) patient had a lymphocele in the inguinal incision area. This complication was eliminated by use of the puncture treatment method. Long-term results in terms of 1 to 3 years were studied in 82 (97.6%) patients. In the long-term period, 1 (1.2%) patient noted the varicose veins recurrence due to neovasculogenesis in the groin. The patient underwent micro-foam echosclerotherapy. Patient`s quality of life was studied by using the CIVIQ2 questionnaire before and 1 year after treatment. It was found that 4 main indicators of the quality of life in the long-term period improved by 35.6-48.8% of the preoperative values. At the same time, the most significant positive dynamics of psychological (48.8%) and pain (47.1%) factors was observed. The results justify the need for a differentiated approach, taking into account the individual characteristics of the disease, as well as the expediency of using minimally invasive techniques in patients with varicose veins recurrence.
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April 2021

Determination of Polycyclic Aromatic Hydrocarbons and Their Methylated Derivatives in Sewage Sludge from Northeastern China: Occurrence, Profiles and Toxicity Evaluation.

Molecules 2021 May 6;26(9). Epub 2021 May 6.

International Joint Research Center for Persistent Toxic Substances (IJRC-PTS), State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology (HIT), Harbin 150090, China.

This paper assesses the occurrence, distribution, source, and toxicity of polycyclic aromatic hydrocarbons (PAHs), and their methylated form (Me-PAHs) in sewage sludge from 10 WWTPs in Northeastern China was noted. The concentrations of ∑PAHs, ∑Me-PAHs ranged from 567 to 5040 and 48.1 to 479 ng.g-1dw, which is greater than the safety limit for sludge in agriculture in China. High and low molecular weight 4 and 2-ring PAHs and Me-PAHs in sludge were prevalent. The flux of sludge PAHs and Me-PAHs released from ten WWTPs, in Heilongjiang province, was calculated to be over 100 kg/year. Principal component analysis (PCA), diagnostic ratios and positive matrix factorization (PMF) determined a similar mixed pyrogenic and petrogenic source of sewage sludge. The average values of Benzo[a]pyrene was below the safe value of 600 ng.g-1 dependent on an incremental lifetime cancer risk ILCR of 10. Sludge is an important source for the transfer of pollutants into the environment, such as PAHs and Me-PAHs. Consequently, greater consideration should be given to its widespread occurrence.
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http://dx.doi.org/10.3390/molecules26092739DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8124507PMC
May 2021

Three-dimensional quantitative muscle ultrasound in a healthy population.

Muscle Nerve 2021 May 25. Epub 2021 May 25.

Department of Imaging, Nuclear Medicine and Anatomy, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.

Introduction/aims: Quantitative muscle ultrasound offers biomarkers that aid in the diagnosis, detection, and follow-up of neuromuscular disorders. At present, quantitative muscle ultrasound methods are 2D and are often operator and device dependent. The aim of this study was to combine an existing device independent method with an automated ultrasound machine and perform 3D quantitative muscle ultrasound, providing new normative data of healthy controls.

Methods: In total, 123 healthy volunteers were included. After physical examination, 3D ultrasound scans of the tibialis anterior muscle were acquired using an automated ultrasound scanner. Image postprocessing was performed to obtain calibrated echo intensity values based on a phantom reference.

Results: Tibialis anterior muscle volumes of 61.2 ± 24.1 mL and 53.7 ± 22.7 mL were scanned in males and females, respectively. Echo intensity correlated with gender**, age**, fat fraction*, histogram kurtosis**, skewness* and standard deviation** (*P < .05, **P < .01). Outcome measures did not differ significantly for different acquisition presets. The 3D quantitative muscle ultrasound revealed the non-uniformity of echo intensity values over the length of the tibialis anterior muscle.

Discussion: Our method extended 2D measurements and confirmed previous findings. Our method and reported normative data of (potential) biomarkers can be used to study neuromuscular disorders.
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http://dx.doi.org/10.1002/mus.27330DOI Listing
May 2021

Occurrence, removal and mass balance of substituted diphenylamine antioxidants in wastewater treatment plants in Northeast China.

Environ Res 2021 07 10;198:111291. Epub 2021 May 10.

International Joint Research Center for Persistent Toxic Substances (IJRC-PTS), State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin, 150090, China; International Joint Research Center for Arctic Environment and Ecosystem (IJRC-AEE), Polar Academy, Harbin Institute of Technology, Harbin, 150090, China; Faculty of Chemistry, Biotechnology & Food Sciences (KBM), Norwegian University of Life Sciences (NMBU), Norway.

Substituted diphenylamine antioxidants (SDPAs) are additives used in various commodities and are commonly found in environmental samples. However, limited information was available on their fate and removal in wastewater treatment plants (WWTPs). This paper reports the results on the occurrence and removal efficiency of ten selected SDPAs in six WWTPs equipped with different treatment processes in Northeast China. Quite similar distributions of different SDPA congeners were shown in the studied WWTPs, with ditertoctyl-diphenylamine (C8/C8-DPA), tertbutyl-tertoctyl-diphenylamine (C4/C8-DPA), and tertoctyl-diphenylamine (C8-DPA) being always dominant in the influent, effluent, and sludge (total > 80%). A cyclic activated sludge system combined with a V-shape filter achieved the highest removal efficiencies of SDPAs among various treatment processes. Styrenated-diphenylamine1 (S-DPA1) (96 ± 10%), C8-DPA (95 ± 5.5%), and distyrenated-diphenylamine1 (DS-DPA1) (94 ± 9.3%) showed high and stable removal efficiencies, whereas C4/C8-DPA (85 ± 31%) and C8/C8-DPA (84 ± 62%) showed considerably varied removal efficiencies. Per-day discharges of SDPAs to the receiving environment through effluent and sludge were estimated as 828 ± 350 and 5578 ± 5196 mg, respectively. A median of 85% of the initial mass loadings of SDPAs was found in the sludge samples, suggesting that the observed removal of SDPAs in the WWTPs was caused by their sorption to the sludge, rather than biodegradation/transformation. This work provides an overall description of the occurrence, fate, and mass balance of SDPAs in WWTPs in Northeast China and highlights a new emission route to the environment via WWTPs.
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http://dx.doi.org/10.1016/j.envres.2021.111291DOI Listing
July 2021

Fate processes of Parabens, Triclocarban and Triclosan during wastewater treatment: assessment via field measurements and model simulations.

Environ Sci Pollut Res Int 2021 May 8. Epub 2021 May 8.

International Joint Research Center for Persistent Toxic Substances (IJRC-PTS), State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin, 150090, China.

The high levels of parabens (including methyl-, ethyl- and propyl congeners), triclocarban (TCC) and triclosan (TCS) used every year in China might be a problem to the typical wastewater treatment plant (WWTP). This study addresses measurements of parabens, TCC and TCS Northern China WWTP and a modelling assessment on the occurrence, fate and removal pathways in WWTP. Per-capita emissions of the three parabens, TCC and TCS to the WWTP were estimated as 0.41, 0.11 and 0.07 mg/d. After the wastewater treatment processes, 94, 92 and 87% of parabens, TCC and TCS were removed. The major removal pathway of parabens was biodegradation while that of TCC and TCS were sorption to sludge. Computer simulations on the fate processes of parabens, TCC and TCS in the WWTP using the SimpleTreat 4.0 model suggested the model could generally reproduce the measurements with root mean squared errors (RMSEs) of less than 10 ng/L. However, the model underestimated the removal of TCC and TCS from water to sludge in the primary tank. These discrepancies were attributed to the uncertainty of the predicted organic carbon-water partition coefficients (K) to which the modelling results are highly sensitive. The model predictions using updated K became more accurate and RMSEs of TCC and TCS were reduced by 40 and 80%, respectively. The modelling assessment suggests that the SimpleTreat, as a generic model to simulate chemical fate processes in WWTPs, has the potential to be applied to other similar WWTPs in China for estimating environmental releases of parabens, TCC and TCS at a larger spatial scale.
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http://dx.doi.org/10.1007/s11356-021-14141-9DOI Listing
May 2021