Publications by authors named "A A Azouz"

50 Publications

Design and Implementation of an Enhanced Matched Filter for Sidelobe Reduction of Pulsed Linear Frequency Modulation Radar.

Sensors (Basel) 2021 Jun 1;21(11). Epub 2021 Jun 1.

Electrical Engineering Branch, Military Technical College, Kobry El-Kobba, Cairo 11766, Egypt.

Pulse compression techniques are commonly used in linear frequency modulated (LFM) waveforms to improve the signal-to-noise ratios (SNRs) and range resolutions of pulsed radars, whose detection capabilities are affected by the sidelobes. In this study, a sidelobe reduction filter (SRF) was designed and implemented using software defined radio (SDR). An enhanced matched filter (EMF) that combines a matched filter (MF) and an SRF is proposed and was implemented. In contrast to the current commonly used approaches, the mathematical model of the SRF frequency response is extracted without depending on any iteration methods or adaptive techniques, which results in increased efficiency and computational speed for the developed model. The performance of the proposed EMF was verified through the measurement of four metrics, including the peak sidelobe ratio (PSLR), the impulse response width (IRW), the mainlobe loss ratio (MLR), and the receiver operational characteristics (ROCs) at different SNRs. The ambiguity function was then used to characterize the Doppler effect on the designed EMF. In addition, the detection of single and multiple targets using the proposed EMF was performed, and the results showed that it overcame the masking problem due to its effective reduction of the sidelobes. Hence, the practical application of the EMF matches the performance analysis. Moreover, when implementing the EMF proposed in this paper, it outperformed the common MF, especially when detecting targets moving at low speeds and having small radar cross-sections (RCS), even under severe masking conditions.
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http://dx.doi.org/10.3390/s21113835DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8199325PMC
June 2021

A Patient with Eosinophilic Esophagitis and Herpes Simplex Esophagitis: A Case Report and Literature Review.

Case Rep Gastrointest Med 2021 25;2021:5519635. Epub 2021 May 25.

Division of Gastroenterology and Hepatology, University of Tennessee Health Science Center, Memphis, TN 38104, USA.

Acute herpes simplex esophagitis (HSE) is common in immunocompromised patients. Eosinophilic esophagitis (EoE) is characterized by immune-mediated eosinophil-predominant esophageal inflammation. We report a patient with human immunodeficiency virus infection who presented with dysphagia and odynophagia and was found to have HSE and EoE. The combination of these two relatively rare conditions suggests possible predisposition.
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http://dx.doi.org/10.1155/2021/5519635DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8169267PMC
May 2021

Novel promising reproductive and metabolic effects of Cicer arietinum L. extract on letrozole induced polycystic ovary syndrome in rat model.

J Ethnopharmacol 2021 Oct 7;278:114318. Epub 2021 Jun 7.

Department of Pathology, Faculty of Veterinary Medicine, Cairo University, Giza, 12211, Egypt. Electronic address:

Ethnopharmacological Relevance: Chickpea was used in both greek and indian traditional medicine for hormonal related conditions as menstrual induction, acceleration of parturation, treatment of retained placenta and stimulation of lactation. Chickpea (Cicer arietinum) sprout isoflavone isolates exhibited reasonable estrogenic activities. Isoflavones, a subtype of phytoestrogens, are plant derivatives with moderate estrogenic activity that tend to have protective effects on hormonal and metabolic abnormalities of women with polycystic ovary syndrome (PCOS).

Aim Of The Study: In this study, we investigated the effect of UPLC/ESI-MS characterized Cicer arietinum L. seeds ethanol extract (CSE) on ovarian hormones, oxidative response and ovarian histological changes on induced PCOS rat model.

Materials And Methods: Thirty-five rats were divided into five groups including negative control, PCOS, and treatment groups. PCOS was induced using letrozole (1 mg/kg) daily orally for 21 days. Each treatment group was treated with one of the following for 28 days after induction of PCOS: clomiphene citrate (1 mg/kg), and CSE at 250 and 500 mg/kg. Ovaries and uteri were excised, weighed and their sections were used for quantitative real-time reverse transcriptase polymerase chain reaction, antioxidant assays and histomorphometric study of the ovaries. The antioxidant assays, histopathological examination, hormonal and metabolic profiles, and Cyp11a1(steroidogenic enzyme) mRNA expression were measured.

Results: In all treatment groups, ovarian weight was significantly decreased despite having no significant effect on uterine weight. Histomorphometric study in the treatment groups revealed a significant decrease in the number and diameter of cystic follicles, a significant increase in granulosa cell thickness while, thickness of theca cells was significantly decreased when compared to PCOS. Hormone levels, metabolic profile and antioxidant status were improved in the treatment groups. Moreover, Cyp11a1 mRNA expression was significantly downregulated in the treatment groups compared to PCOS.

Conclusions: In the current study, CSE enhanced the reproductive and metabolic disorders which were associated with PCOS induction. For the first time, we have highlighted the effect of CSE in treating PCOS and its associated manifestations.
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http://dx.doi.org/10.1016/j.jep.2021.114318DOI Listing
October 2021

Linum usitatissimum seeds oil down-regulates mRNA expression for the steroidogenic acute regulatory protein and Cyp11A1 genes, ameliorating letrezole-induced polycystic ovarian syndrome in a rat model.

J Physiol Pharmacol 2021 Feb 3;72(1). Epub 2021 Jun 3.

Department of Physiology, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt.

The safety and effectiveness of nutricetics suggest that they may offer an alternative to pharmaceutical and surgical therapy for hormone-dependent disorders, such as polycystic ovarian syndrome (PCOS). We investigated the effects of Linum usitatissimum seed oil (LSO) on ovarian functionality, its molecular targets, and the oxidative response in hyperandrogenism-induced polycystic ovary. The composition of LSO has been analyzed using ultra-performance liquid chromatography-electrospray ionization-tandem mass spectrometry (UPLC-ESI-MS). A well-established PCOS rat model orally administered with letrozole daily for 21 days was used to investigate the effect of LSO at doses of 1 and 2 mL/kg body weight for 28 days. The effect on hormonal profile and antioxidant status, histopathology (cell proliferation), and the expression ratio of the steroidogenic acute regulatory protein (StAR) and Cyp11A1 gene were evaluated. LSO exerted beneficial effects on PCOS rat models via restoring glutathione (GSH), malondialdehyde (MDA), beta subunit subunit luteinizing hormone (LH), testosterone levels, and histopathological scoring. Furthermore, LSO reversed the elevated StAR and Cyp11A1 genes in the PCOS rat model. This study demonstrated the molecular and cellular mechanisms of the beneficial effect of LSO against the reproductive and metabolic disorders of PCOS.
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http://dx.doi.org/10.26402/jpp.2021.1.06DOI Listing
February 2021

Benzyl isothiocyanates modulate inflammation, oxidative stress, and apoptosis via Nrf2/HO-1 and NF-κB signaling pathways on indomethacin-induced gastric injury in rats.

Food Funct 2021 Jul 26;12(13):6001-6013. Epub 2021 May 26.

Department of Pharmacology, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt.

The present study investigated the gastroprotective activity of benzyl isothiocyanates (BITC) on indomethacin (IND)-induced gastric injury in a rat model and explicated the possible involved biochemical, cellular, and molecular mechanisms. The rat model with gastric ulcers was established by a single oral dose of IND (30 mg per kg b.wt). BITC (0.75 and 1.5 mg kg) and esomeprazole (20 mg per kg b.wt) were orally administered for 3 weeks to rats before the induction of gastric injury. Compared with the IND group, BITC could diminish both the macroscopic and microscopic pathological morphology of gastric mucosa. BITC significantly preserved the antioxidants (glutathione GSH, superoxide dismutase SOD), nitric oxide (NO), and prostaglandin E2 (PGE2) contents, while decreasing the gastric mucosal malondialdehyde (MDA), tumor necrosis factor alpha (TNFα), and myeloperoxidase (MPO) contents. Moreover, BITC remarkably upregulated the expression of nuclear factor erythroid 2-related factor 2 (Nrf2), hemoxygenase-1 (HO-1), and NAD(P)H : quinone oxidoreductase (NQO1). In addition, BITC activates the expression of heat shock protein 70 (HSP-70) and downregulated the expression of nuclear factor-κB (NF-κB) and caspase-3 to promote gastric mucosal cell survival. To the best of our knowledge, this study is the first published report to implicate the suppression of inflammation, oxidative stress, and Nrf2 signaling pathway as a potential mechanism for the gastroprotective activity of BITC.
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http://dx.doi.org/10.1039/d1fo00645bDOI Listing
July 2021
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