Publications by authors named "Özge Pasin"

9 Publications

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A bibliometric analysis of rheumatology and COVID-19 researches.

Clin Rheumatol 2021 Jul 2. Epub 2021 Jul 2.

Department of Physical Medicine and Rehabilitation, Istanbul Goztepe Training and Research Hospital, Istanbul, Turkey.

Objective: COVID-19 has had a substantial impact on rheumatology. There were many studies about rheumatology and COVID-19. But there is no study about bibliometric analysis of these studies. This study provides a general overview of studies on rheumatology and COVID-19.

Methods: Data were taken from the Web of Science (WoS) website. Analysis and network visualization mapping processes were carried out using VOSviewer. We used the following keywords: "COVID-19" and "Rheumatology"; "Coronavirus" and "Rheumatology"; "2019-nCoV" and "Rheumatology"; "SARS-CoV-2" and "Rheumatology"; "COVID-19" and "Rheumatic Disease"; "Coronavirus" and "Rheumatic Disease"; "2019-nCoV" and "Rheumatic Disease"; "SARS-CoV-2" and "Rheumatic Disease"; "COVID-19" and "Rheumatism"; "Coronavirus" and "Rheumatism"; "2019-nCoV" and "Rheumatism"; and "SARS-CoV-2" and "Rheumatism." A total of 234 publications were analyzed, and the correlations between citation numbers and reference counts, usage counts, and page numbers were analyzed with Spearman correlation coefficients.

Results: The average number of citations per item was 6.03. The studies were cited 1411 times in total, and 1121 times without self-citations. The countries with the highest number of publications on rheumatology and COVID-19 were the USA and England; the countries with the highest number of citations were Italy and the USA, and Jinoos Yazdany was the most cited author. The Annals of the Rheumatic Diseases was the most cited journal, whereas the highest number of articles on rheumatology and COVID-19 were published in Arthritis and Rheumatology.

Conclusions: Bibliometric analysis of rheumatology and COVID-19 can be useful to future studies because it provides a general perspective on the studies. This study provides an insight into the development of publications on rheumatology during the COVID-19 pandemic. Key Points • Covid-19 has substantial impact on rheumatology. • There many studies about rheumatology and COVID-19. But there is no study about bibliometric analysis of these studies. • This study provides a general perspective of the studies about rheumatology and COVID-19. • This study aims to inform the efforts to improve the studies about rheumatology studies during the pandemic process and to analyze the publications about both rheumatology and COVID-19 with bibliometric methods. • Bibliometric analysis about rheumatology and COVID-19 can be useful and helpful tool for future studies.
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http://dx.doi.org/10.1007/s10067-021-05844-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8253236PMC
July 2021

A Bibliometric Analysis of Covid-19 and the Association with the Number of Total Cases.

Disaster Med Public Health Prep 2021 Jun 8:1-24. Epub 2021 Jun 8.

MD, Department of Physical Medicine and Rehabilitation, Istanbul Goztepe Training and Research Hospital, Istanbul, Turkey.

Background: COVID-19 has spread quickly all over the world. The number of studies in this field is increasing day by day and being cited.

Objective: The aim of this study is to analyze the publications in the field of COVID-19 with the help of bibliometric methods. After bibliometric analysis,the second aim is to investigate the relationship between the number of publications in countries and the number of total cases.

Methods: The data in the study were taken from the Web of Science(WOS) site. Analyzes and mapping processes were performed using VOSviewer and SPSS package program. The words "COVID-19", "Novel Coronavirus", "2019-nCoV", "SARS-CoV-2" were used as key words for analysis. The data includes publications from 2019 and up to 2021(January 10).

Results: As a result of the study, a total of 38080 publications were evaluated. It was determined that the countries with the highest number of publications on COVID-19 were China and USA, and the country with the highest number of citations was China. Most of the studies in the field of COVID-19 have been conducted on General Internal Medicine and Public Enviromental Occupational Health. In addition, statistically significant relationships were observed between the number of publications and the number of total cases in terms of countries(r=0.806, p<0.001).

Conclusion: As a result, bibliometric analysis about COVID-19 can be useful for the future studies. It gives a general perspective of the studies.
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http://dx.doi.org/10.1017/dmp.2021.177DOI Listing
June 2021

Detection of altered methylation of MB-COMT promotor and DRD2 gene in cannabinoid or synthetic cannabinoid use disorder regarding gene variants and clinical parameters.

J Addict Dis 2021 Mar 29:1-19. Epub 2021 Mar 29.

Department of Medical Biology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.

This study aims to investigate the association between cannabinoid use disorder (CUD) or synthetic cannabinoid use disorder (SCUD) and methylation status of MB-COMT (membrane-bound catechol-O-methyltransferase) promotor or DRD2 gene considering gene variants and clinical parameters. Based on the DSM-5 criteria, 218 CUD/SCUD patients' diagnoses were confirmed with a positive urine test, and a control group consisting of 102 participants without substance use disorders was included. Methylation-specific PCR was used to identify the methylation of the MB-COMT promotor and DRD2 gene. DRD2-141C Ins/Del and COMT Val158Met gene variants were evaluated by using PCR-RFLP. When the DRD2 and MB-COMT promoter methylation of CUD/SCUD patients were compared with the control group, there was a significant difference between the MB-COMT promoter methylation status of the two groups. When comparing DRD2 gene methylation due to clinical parameters and DRD2 genotype distribution in patients, the methylation status was significantly different between the groups due to the family history. Again, comparing the MB-COMT promotor methylation due to the COMT Val158Met genotype distribution and clinical parameters in patients, the MB-COMT promoter methylation status was significantly different between the groups due to the presence of alcohol usage. In summary, whereas the MB-COMT promoter methylation may be associated with the CUD/SCUD, the methylation of the DRD2 gene was not related to CUD/SCUD.
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http://dx.doi.org/10.1080/10550887.2021.1906618DOI Listing
March 2021

Modeling of COVID-19 Outbreak Indicators in China Between January and June.

Disaster Med Public Health Prep 2020 Sep 9:1-9. Epub 2020 Sep 9.

Department of Biostatistics, Faculty of Medicine, Istanbul University, Istanbul, Turkey.

Objectives: The objective of this study is to compare the various nonlinear and time series models in describing the course of the coronavirus disease 2019 (COVID-19) outbreak in China. To this aim, we focus on 2 indicators: the number of total cases diagnosed with the disease, and the death toll.

Methods: The data used for this study are based on the reports of China between January 22 and June 18, 2020. We used nonlinear growth curves and some time series models for prediction of the number of total cases and total deaths. The determination coefficient (R2), mean square error (MSE), and Bayesian Information Criterion (BIC) were used to select the best model.

Results: Our results show that while the Sloboda and ARIMA (0,2,1) models are the most convenient models that elucidate the cumulative number of cases; the Lundqvist-Korf model and Holt linear trend exponential smoothing model are the most suitable models for analyzing the cumulative number of deaths. Our time series models forecast that on 19 July, the number of total cases and total deaths will be 85,589 and 4639, respectively.

Conclusion: The results of this study will be of great importance when it comes to modeling outbreak indicators for other countries. This information will enable governments to implement suitable measures for subsequent similar situations.
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http://dx.doi.org/10.1017/dmp.2020.323DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7642915PMC
September 2020

Assessment of death risk of breast cancer patients with joint frailty models.

Saudi Med J 2020 May;41(5):491-498

Department of Biostatistics, Faculty of Medicine, Istanbul University, Istanbul, Turkey. E-mail.

Objectives: To investigate the effects of risk factors on recurrence and death in breast cancer patients, taking into account the dependence between recurrence and death as well as the heterogeneity among individuals. The other aim of this study was to make predictions of death risks with a dynamic model that includes patient's history and different horizons. Methods: The data of 465 patients who had undergone surgery at the Istanbul University Oncology Institute,  Istanbul, Turkey, between 2009 and 2016 were used. For data analysis in this retrospective study, the authors applied the joint frailty model, and the predictions were obtained using dynamic prediction methods that consider the patient's history. The Brier score was used to evaluate the accuracy of the estimations.

Results: A positive relationship was found between recurrence and death, and heterogeneity was found among patients (p less than 0.001, p=1.008, p=2.945). The effects of Cerb-B2, tumor type, remaining lymph nodes, neoadjuvant chemotherapy, and surgery type were statistically significant for death and recurrence (p less than 0.05, relative risk [death, recurrence] = [2.5, 11.86], [2.065, 2.798], [1.852, 3.113], [4.211, 9.366], [1.521,1.991]). The Brier score values used in the evaluation of the predictions obtained by the dynamic prediction methods were found to be below 0.30. Conclusion: The use of joint frailty models is recommended for the detection of heterogeneity effects and dependence between recurrence and death. Through models in survival analysis, researchers can obtain more accurate parameter estimates. A significant variance of frailty indicates different death risks for the same characteristics.
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http://dx.doi.org/10.15537/smj.2020.5.25065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253835PMC
May 2020

Comparison of the Effectiveness of Platelet-Rich Plasma, Corticosteroid, and Physical Therapy in Subacromial Impingement Syndrome.

Arch Rheumatol 2019 09 28;34(3):308-316. Epub 2019 Mar 28.

Department of Biostatistics, Istanbul Medeniyet University Faculty of Medicine, Istanbul, Turkey.

Objectives: This study aims to investigate and compare the efficacy of platelet-rich plasma (PRP) injection, corticosteroid injection, and physical therapy in addition to exercise treatment on pain, shoulder functions, and quality of life in patients with subacromial impingement syndrome (SAIS).

Patients And Methods: Ninety patients (37 males, 53 females; mean age 48.99 years; range, 33 to 60 years) who were diagnosed as Stage 2 SAIS were included in the study. Patients were randomized into three groups. PRP injection was administered into the subacromial space of the affected shoulder in group 1, corticosteroid injection was administered in the subacromial joint space in group 2, and 10 sessions of physical therapy were given in group 3 five times weekly including transcutaneous electrical nerve stimulation, ultrasound, and hot packs. Moreover, an exercise program was administered in all groups. Visual Analog Scale (VAS) was used to determine the resting and moving shoulder pain; while the Shoulder Disability Questionnaire, Quick Disabilities of the Arm, Shoulder, and Hand (QuickDASH) questionnaire, and the University of California, Los Angeles Shoulder Rating Scale (UCLA SRS) were used to evaluate the functionality of patients. Quality of life was analyzed using a generic Short Form 36 (SF-36).

Results: All scores improved in all three groups compared with the period before treatment. Comparison of the groups showed higher scores in group 1 compared to groups 2 and 3 at week eight on QuickDASH, UCLA SRS, VAS at rest and during activity, and SF-36 pain subgroup scores.

Conclusion: All three treatment modalities were effective in the treatment of SAIS. However, we suggest that the inexpensive and noninvasive methods of physical therapy and exercise should be the first preferred treatment in SAIS owing to causing no adverse events.
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http://dx.doi.org/10.5606/ArchRheumatol.2019.7225DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6768781PMC
September 2019

Propofol-based balanced anesthesia is safer in pediatric radiotherapy.

J Oncol Pharm Pract 2019 Dec 30;25(8):1891-1896. Epub 2019 Jan 30.

Cerrahpasa Medical Faculty, Department of Anesthesiology, Istanbul University, Istanbul, Turkey.

Backround And Purpose: To investigate the incidence of complications related to propofol-based anesthesia and the factors associated with complications in children with radiotherapy.

Materials And Methods: Patients who underwent anesthesia for external beam radiotherapy between May 2013 and November 2017 were included in the study. We assessed the age/weight, sex, oncologic diagnosis, type of radiotherapy procedure, duration of anesthesia, applied agents, and complications related to anesthesia. Complications were evaluated between group I (only propofol group) and group II (propofol plus adjuvant drugs) as respiratory and cardiac.

Results: In 130 patients, sedation was given for 1376 radiotherapy procedures. Of these, 1274 (1140 radiation treatment sessions and 134 computed tomography simulations) in 126 patients were propofol-based and were included in the analysis. Although respiratory complications are the most common in both groups, there were no episodes of laryngospasm, broncospasm, and no use of advanced airway intervention. The rate of complication was significantly higher in only propofol anesthesia group than in patients treated with propofol plus adjuvant drugs. In the multivariate analysis, we found three factors that were significantly associated with the risk of complications: total dose of propofol (mg/kg) (p < 0.001), anesthesia with propofol alone (as compared to propofol plus adjunct agents) (p = 0.001), and diagnosis of neuroblastoma (as compared to other diagnosis) (p = 0.043).

Conclusion: Propofol-based anesthesia is preferred in order to minimize the rate of complications in radiotherapy anesthesia applications. The use of non-opioid adjuvants in combination with propofol to achieve a balanced anesthesia will also reduce the complications that may be encountered.
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http://dx.doi.org/10.1177/1078155218825296DOI Listing
December 2019

Durasphere® EXP: a non-biodegradable agent for treatment of primary Vesico-Ureteral reflux in children.

Int Braz J Urol 2018 May-Jun;44(3):585-590

Department of Urology Haseki Training and Research Hospital, Fatih, Istanbul, Turkey.

Introduction: Durasphere® EXP (DEXP) is a compound of biocompatible and non-biodegradable particles of zirconium oxide covered with pyrolytic carbon. The aim of this study is to evaluate the durability of off-label use of DEXP in the treatment of primary vesicoureteral reflux in children.

Materials And Methods: Patients who underwent subureteric injection of DEXP for the correction of primary VUR were retrospectively reviewed . Patients aged >18 years as well as those who had grade-I or -V VUR, anatomic abnormalities (duplicated system, hutch diverticulum), neurogenic bladder or treatment refractory voiding dysfunction were excluded. Radiologic success was defined as the resolution of VUR at the 3rd month control. Success was radiographically evaluated at the end of the first year.

Results: Thirty-eight patients (9 boys, 29 girls; mean age, 6.3±2.7 years) formed the study cohort. Forty-six renal units received DEXP (grade II: 22; grade III: 18; grade IV: 6). Mean volume per ureteric orifice to obtain the mound was 0.70±0.16mL. First control VCUG was done after 3 months in all patients. After the first VCUG, 6 patients had VUR recurrence. Short-term radiologic success of DEXP was 84.2%. Rate of radiologic success at the end of the first year was 69.4% (25/32). Lower age (p:0.006) and lower amount of injected material (p:0.05) were associated with higher success rates at the end of 1 year.

Conclusion: This is the first study to assess the outcomes of DEXP for treatment of primary VUR in children. After 1 year of follow-up, DEXP had a 69.4% success rate.
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http://dx.doi.org/10.1590/S1677-5538.IBJU.2017.0514DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5996799PMC
July 2018

Comparing Performances of Multiple Comparison Methods in Commonly Used 2 × C Contingency Tables.

Interdiscip Sci 2016 Dec 10;8(4):337-345. Epub 2015 Oct 10.

Department of Biostatistics and Medical Informatics, Faculty of Medicine, Duzce University, Duzce, Turkey.

This study aims at mentioning briefly multiple comparison methods such as Bonferroni, Holm-Bonferroni, Hochberg, Hommel, Marascuilo, Tukey, Benjamini-Hochberg and Gavrilov-Benjamini-Sarkar for contingency tables, through the data obtained from a medical research and examining their performances by simulation study which was constructed as the total 36 scenarios to 2 × 4 contingency table. As results of simulation, it was observed that when the sample size is more than 100, the methods which can preserve the nominal alpha level are Gavrilov-Benjamini-Sarkar, Holm-Bonferroni and Bonferroni. Marascuilo method was found to be a more conservative than Bonferroni. It was found that Type I error rate for Hommel method is around 2 % in all scenarios. Moreover, when the proportions of the three populations are equal and the proportion value of the fourth population is far at a level of ±3 standard deviation from the other populations, the power value for Unadjusted All-Pairwise Comparison approach is at least a bit higher than the ones obtained by Gavrilov-Benjamini-Sarkar, Holm-Bonferroni and Bonferroni. Consequently, Gavrilov-Benjamini-Sarkar and Holm-Bonferroni methods have the best performance according to simulation. Hommel and Marascuilo methods are not recommended to be used because they have medium or lower performance. In addition, we have written a Minitab macro about multiple comparisons for use in scientific research.
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http://dx.doi.org/10.1007/s12539-015-0128-5DOI Listing
December 2016