Guillain-Barre Syndrome Publications (8333)


Guillain-Barre Syndrome Publications

Ir Med J
Ir Med J 2016;109(2):357. Epub 2016 Feb 19.
Health Protection Surveillance Centre, 25-27 Middle Gardiner St, Dublin 1.

Acute Flaccid Paralysis (AFP) surveillance, including case investigation and specimen collection is a gold standard method for poliomyelitis surveillance. The expected annual non-polio AFP rate <15 years of age in Ireland is = 1/100 000 population. This study reviewed all cases of AFP reported to the Irish Paediatric Surveillance Unit and the Health Protection Surveillance Centre between January 2009 and December 2014 and compared reporting rates with the expected incidence rate annually. Read More

We assessed quality of surveillance data in terms of completeness of investigation for each case reported. Forty-three AFP cases in children <15 years were notified; 35 of which were confirmed. Guillain-Barre Syndrome (GBS) accounted for 48.6% (n=17) of AFP notifications. In 2014, the expected annual AFP target rate was reached. This study identified possible under-reporting of AFP paediatric cases in Ireland between 2009-2013. Completeness of investigations has improved over time, but requires further work.


The high-level mobility assessment tool (HiMAT) was developed to quantify balance and mobility problems after traumatic brain injury (TBI). The revised HiMAT is valid for people with neurological diseases. The aim of this cohort study was to translate and investigate the internal consistency, reliability of the French version in people with neurological conditions. Read More

The original version of HiMAT was translated into French, cross-culturally adapted and field tested. Patients were recruited from "L'Espoir" Rehabilitation Center. All patients were tested with the HiMAT (range of scores=0 [worst] to 54 [best]). There was one day between 2 tests to avoid fatigue. Two testers independently rated patients. Testers were an experienced physiotherapist and a young physiotherapist (less than 1 year after graduate). Young physiotherapist was trained by a view of the test and the instructions sheet. Internal consistency was investigated with Cronbach alpha. Intraclass correlation coefficients (ICCs) were used for assessing interrater and intrarater reliability (HiMAT sum score and each HiMAT item). Minimal detectable change (MDC) for the HiMAT was estimated. A Friedman test was used to investigate the presence of a learning effect.
Currently, 9 patients were included. Six had a stroke, 1 a Guillain-Barré syndrome, 1 a spinal cord tumor treated by neurosurgery and 1 had an unknown peripheral disease affecting lower limbs. The HiMAT had no floor or ceiling effect. Internal consistency was excellent (α=. 975). Interrater and intrarater reliability of the HiMAT score was high (interrater ICC=. 99, intrarater ICC=. 99). The MDC was-2 to+4 points. No learning effect occurred (P=0, 845).
The French version of the HiMAT seems to be a reliable tool to measure high-level mobility in people with neurological conditions.

Arboviruses cause very recurrent epidemics, the oldest Dengue, known especially outside the flu-like syndrome with high fever mainly impacting vulnerable populations, may be responsible for severe hemorrhagic fevers, but also a few cases of Guillain-Barré syndrome. In 2014, the French Antilles occurred an outbreak of Chikungunya, following that of the Reunion's outbreak. During this period have been described, the articular and musculo-squellettic lesions, responsible for loss of autonomy in populations already carriers of chronic inflammatory joint damage or mechanical, but also a heavy impact on the autonomy of elderly and frail people. Read More

The Reunion experience has allowed the French Antilles to prepare for managing this epidemic by implementing an algorithm based on precise stripping algic and incapacitating phenomena. The role of the MPR in this dismemberment will allows distinguish true neurogenic damage to types of complex pain syndrome, combining autonomic neuropathy syndromes and tables of small fibers at the crossroads between diagnostic of arthropathy of periarthropaties, synovitis, tenosynovitis and tunnel syndrome on the rise during this epidemic period. And other complications such as bladder and sphincter disorders, and increase of spastic tables in patients suffering from chronic neurological disease. The reach of virus Zika shows an increased incidence of Guillain-Barre syndrome, brings interrogation with the appearance of atypical neurological damage such as myelitis, meningitis, cerebellites showing well this neurotropism. There are also atypical presentation on the neuro-urology plan that raises the question of the pathophysiology of such viruses. As has been the case for the Chikungunya, the overall vision of the MPR will allow better interpretation of pathological phenomena helping the understanding of the pathophysiology of these arboviruses. But it also plays a role in measuring the impact of emerging diseases on the autonomy of individuals.

Eur. Neurol.
Eur Neurol 2016 Sep 27;76(3-4):182-186. Epub 2016 Sep 27.
Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
J Assoc Physicians India
J Assoc Physicians India 2015 Dec;63(12):11-12
Associate Professor of Medicine and I/C Rheumatology, Hinduhridaysamrat Balasaheb Thakeray Medical College and R.N. Cooper Hospital; Visiting Consultant Rheumatologist, Sevenhills Hospital, Mumbai, Maharashtra.

SLE (systemic lupus erythematosus) is a multisystem autoimmune disorder of unknown aetiology which can present with myriad clinical presentation. The neurological manifestations of SLE consist of central nervous system (CNS) and peripheral nervous system manifestations (PNS). The CNS manifestations are aseptic meningitis, cerebrovascular accidents (stroke), demyelinating disorders, headache, involuntary movements like chorea, myelopathy, acute confusional states, cognitive dysfunction, mood disorder, seizures, psychosis and cranial nerve palsies. Read More

1 The PNS manifestations are Guillain Barre syndrome (GBS), autonomic disorder, mononeuropathy, polyneuropathy and plexopathy.1 Neuropathy in SLE can be clinically classified as mononeuritis multiplex and symmetrical and asymmetrical polyneuropathy. Symmetrical polyneuropathy being the most commonly seen clinical entity amongst the neuropathies in SLE. The neuropathy can be slowly progressive or acute in onset. Electrophysiologically, neuropathy is classified as axonal neuropathy, small fibre neuropathy, demyelinating neuropathy, mixed axonal-demyelinating sensorimotor polyneuropathy and plexopathy. Axonal neuropathy is further divided into sensory, sensorimotor and mononeuritis multiplex. Demyelinating neuropathy can be of two types: acute inflammatory demyelinating polyneuropathy (AIDP) and sensory demyelinating polyneuropathy. Anecdotal case reports also suggest that CIDP can occur as part of SLE neuropathy.2.