Guillain-Barre Syndrome Publications (8165)

Search

Guillain-Barre Syndrome Publications

Zika virus (ZIKV) is an emergent threat provoking a worldwide explosive outbreak. Since January 2015, 41 countries reported autochthonous cases. In Brazil, an increase in Guillain-Barré syndrome and microcephaly cases was linked to ZIKV infections. Read More

A recent report describing low experimental transmission efficiency of its main putative vector, Ae. aegypti, in conjunction with apparent sexual transmission notifications, prompted the investigation of other potential sources of viral dissemination. Urine and saliva have been previously established as useful tools in ZIKV diagnosis. Here, we described the presence and isolation of infectious ZIKV particles from saliva and urine of acute phase patients in the Rio de Janeiro state, Brazil.
Nine urine and five saliva samples from nine patients from Rio de Janeiro presenting rash and other typical Zika acute phase symptoms were inoculated in Vero cell culture and submitted to specific ZIKV RNA detection and quantification through, respectively, NAT-Zika, RT-PCR and RT-qPCR. Two ZIKV isolates were achieved, one from urine and one from saliva specimens. ZIKV nucleic acid was identified by all methods in four patients. Whenever both urine and saliva samples were available from the same patient, urine viral loads were higher, corroborating the general sense that it is a better source for ZIKV molecular diagnostic. In spite of this, from the two isolated strains, each from one patient, only one derived from urine, suggesting that other factors, like the acidic nature of this fluid, might interfere with virion infectivity. The complete genome of both ZIKV isolates was obtained. Phylogenetic analysis revealed similarity with strains previously isolated during the South America outbreak.
The detection of infectious ZIKV particles in urine and saliva of patients during the acute phase may represent a critical factor in the spread of virus. The epidemiological relevance of this finding, regarding the contribution of alternative non-vectorial ZIKV transmission routes, needs further investigation.

Zika virus is a member of the flavivirus genus that had not been associated with severe disease in humans until the recent outbreaks, when it was linked to microcephaly in newborns in Brazil and to Guillain-Barré syndrome in adults in French Polynesia. Zika virus is related to dengue virus, and we report here that a category of antibodies isolated from dengue patients and targeting a conformational epitope potently neutralize Zika virus. The crystal structure of two of these antibodies in complex with the envelope protein of Zika virus reveals the details of a conserved epitope, which is also the site of interaction of the envelope protein dimer with the precursor prM protein during virus maturation. Read More

Comparison of the Zika and dengue virus immunocomplexes provides a lead for rational, epitope-focused design of a universal vaccine capable of eliciting potent cross-neutralizing antibodies to protect against Zika and dengue viruses simultaneously.

Zika virus has rapidly spread through the World Health Organization's Region of the Americas since being identified in Brazil in early 2015. Transmitted primarily through the bite of infected Aedes species mosquitoes, Zika virus infection during pregnancy can cause spontaneous abortion and birth defects, including microcephaly (1,2). New York City (NYC) is home to a large number of persons who travel frequently to areas with active Zika virus transmission, including immigrants from these areas. Read More

In November 2015, the NYC Department of Health and Mental Hygiene (DOHMH) began developing and implementing plans for managing Zika virus and on February 1, 2016, activated its Incident Command System. During January 1-June 17, 2016, DOHMH coordinated diagnostic laboratory testing for 3,605 persons with travel-associated exposure, 182 (5.0%) of whom had confirmed Zika virus infection. Twenty (11.0%) confirmed patients were pregnant at the time of diagnosis. In addition, two cases of Zika virus-associated Guillain-Barré syndrome were diagnosed. DOHMH's response has focused on 1) identifying and diagnosing suspected cases; 2) educating the public and medical providers about Zika virus risks, transmission, and prevention strategies, particularly in areas with large populations of immigrants from areas with ongoing Zika virus transmission; 3) monitoring pregnant women with Zika virus infection and their fetuses and infants; 4) detecting local mosquito-borne transmission through both human and mosquito surveillance; and 5) modifying existing Culex mosquito control measures by targeting Aedes species of mosquitoes through the use of larvicides and adulticides.

2016May
West J Emerg Med
West J Emerg Med 2016 May 4;17(3):238-44. Epub 2016 Apr 4.
University of California Irvine Medical Center, Department of Emergency Medicine and Department of Medicine, Division of Infectious Diseases, Orange, California.

First isolated in 1947 from a monkey in the Zika forest in Uganda, and from mosquitoes in the same forest the following year, Zika virus has gained international attention due to concerns for infection in pregnant women potentially causing fetal microcephaly. More than one million people have been infected since the appearance of the virus in Brazil in 2015. Approximately 80% of infected patients are asymptomatic. Read More

An association with microcephaly and other birth defects as well as Guillain-Barre Syndrome has led to a World Health Organization declaration of Zika virus as a Public Health Emergency of International Concern in February 2016. Zika virus is a vector-borne disease transmitted primarily by the Aedes aegypti mosquito. Male to female sexual transmission has been reported and there is potential for transmission via blood transfusions. After an incubation period of 2-7 days, symptomatic patients develop rapid onset fever, maculopapular rash, arthralgia, and conjunctivitis, often associated with headache and myalgias. Emergency department (ED) personnel must be prepared to address concerns from patients presenting with symptoms consistent with acute Zika virus infection, especially those who are pregnant or planning travel to Zika-endemic regions, as well as those women planning to become pregnant and their partners. The identify-isolate-inform (3I) tool, originally conceived for initial detection and management of Ebola virus disease patients in the ED, and later adjusted for measles and Middle East Respiratory Syndrome, can be adapted for real-time use for any emerging infectious disease. This paper reports a modification of the 3I tool for initial detection and management of patients under investigation for Zika virus. Following an assessment of epidemiologic risk, including travel to countries with mosquitoes that transmit Zika virus, patients are further investigated if clinically indicated. If after a rapid evaluation, Zika or other arthropod-borne diseases are the only concern, isolation (contact, droplet, airborne) is unnecessary. Zika is a reportable disease and thus appropriate health authorities must be notified. The modified 3I tool will facilitate rapid analysis and triggering of appropriate actions for patients presenting to the ED at risk for Zika.

2016Jun
J. Viral Hepat.
J Viral Hepat 2016 Jun 21. Epub 2016 Jun 21.
Laboratory of Animal Pathology and Public Health, Key Laboratory of Zoonosis of Ministry of Agriculture, College of Veterinary Medicine, China Agriculture University, Beijing, China.

Neurologic dysfunctions such as Guillain-Barre' syndrome, encephalitis, meningitis and transverse myelitis occur frequently in patients with hepatitis E virus (HEV) infection, and this study was conducted to better characterize the role of HEV in the pathogenesis of neurologic disorders. Genotype 4 strain of swine HEV was used to inoculate Mongolian gerbils. Reverse transcription-nested polymerase chain reaction (RT-nPCR), ELISA, histopathology, ultrastructural pathology and enzyme immunohistochemistry method were conducted to investigate the replication and localization of HEV in the central nervous system (CNS) and the consequent pathological changes. Read More

Both positive- and negative-strand HEV RNA was detectable in brain and spinal cord from 7 to 28 dpi (days postinoculation) via RT-nPCR. Various pathological changes such as perineural invasion, neuron necrosis, microglia nodule, lymphocyte infiltration, perivascular cuff and myelin degeneration were observed in HEV-positive brains and spinal cords. Immunohistochemical (IHC) staining targeting on HEV ORF2 protein revealed positive signals concentrated mainly in the cytoplasm of neuron, ependymal epithelium and choroid plexus area. Positive area density of ZO-1 (zonula occludens-1) in brain of HEV-positive gerbils decreased, while the GFAP (glial fibrillary acidic protein) expression was upregulated compared with control groups. These results provide strong evidence that HEV is able to damage the blood-brain barrier (BBB), replicate in brain and spinal cord, and hammer the causative role of HEV in the pathogenesis of neurologic disorders.

2016Jun
Ann Intensive Care
Ann Intensive Care 2016 Jun;6(Suppl 1):50
Emmanuelle Jaillette, Christophe Girault, Guillaume Brunin, Farid Zerimech, Arnaud Chiche, Céline Broucqsault-Dedrie, Cyril Fayolle, Franck Minacori, Isabelle Alves, Stephanie Barrailler, Laurent Robriquet, Emmanuel Delaporte, Damien Thellier, Claire Delcourte, Alain Duhamel, Saad Nseir, Xavier Valette, Isabelle Desmeulles, Benoit Savary, Romain Masson, Amélie Seguin, Cédric Daubin, Bertrand Sauneuf, Pierre Verrier, Véronique Pottier, Marie Orabona, Désiré Samba, Gérald Viquesnel, Mathilde Lermuzeaux, Pascal Hazera, Jean-Luc Hanouz, Jean-Jacques Parienti, Damien Du Cheyron, Alexandre Demoule, Marc Clavel, Camille Rolland-Debord, Sébastien Perbet, Nicolas Terzi, Achille Kouatchet, Florent Wallet, Hadrien Roze, Frédéric Vargas, Claude Guérin, Jean Dellamonica, Samir Jaber, Thomas Similowski, Jean-Pierre Quenot, Christine Binquet, Christophe Vinsonneau, Saber-Davide Barbar, Sandrine Vinault, Valérie Deckert, Stephanie Lemaire, Ali Ait Hssain, Rémi Bruyère, Bertrand Souweine, Laurent Lagrost, Christophe Adrie, Boris Jung, Aurelien Daurat, Audrey De Jong, Gérald Chanques, Martin Mahul, Marion Monnin, Nicolas Molinari, Olivier Lheureux, Eric Trepo, Maya Hites, Frederic Cotton, Fleur Wolff, Rudy Surin, Jacques Créteur, Jean-Louis Vincent, Thierry Gustot, Frederique Jacobs, Fabio Silvio Taccone, Mathilde Neuville, Jean-François Timsit, Najoua El-Helali, Alban Le Monnier, Eric Magalhaes, Aguila Radjou, Roland Smonig, Jean-François Soubirou, Guillaume Voiriot, Romain Sonneville, Lila Bouadma, Bruno Mourvillier, Elodie Gélisse, Alexandre Brasseur, Sandrine Roisin, Daniel De Backer, Valerie Van Ruychevelt, Eric Carlier, Michael Piagnerelli, Michel Vanhaeverbeek, Christine Danguy, Patrick Biston, Siu-Ming Au, Emmanuelle Begot, François Dalmay, Xavier Repessé, Gwenael Prat, Koceila Bouferrache, Michel Slama, Antoine Vieillard-Baron, Xavier Monnet, Paul Marik, Jean-Louis Teboul, Mathieu Jozwiak, Christian Richard, Jean-Louis Chauvet, Shari El-Dash, Olivier Delastre, Bernard Bouffandeau, Dominique Jusserand, Jean-Baptiste Michot, Fabrice Bauer, François Brazier, Pablo Mercado, Loay Kontar, Dimitri Titeca, Bertand De Cagny, Gaelle Bacari-Risal, Antoine Riviere, Julien Maizel, Camille Guillot, Claire Le Reun, Marie Lampin, Ahmed Sadik, Astrid Botte, Stéphane Leteurtre, Aurélie Collins, Céline Kempeneers, Nathalie Cajgfinger, Camille Ohlmann, Robin Pouyau, Fabien Subtil, Florent Baudin, Bruno Massenavette, Etienne Javouhey, Christophe Milesi, Sandrine Essouri, Jean-Michel Liet, Mickael Afanetti, Sabine Durand, Philippe Durand, Jean Christophe Roze, Didier Dupont, Gilles Cambonie, Benjamin Soyer, Marco Rusca, Anne-Claire Lukaszewicz, Isabelle Crassard, Jean-Pierre Guichard, Damien Bresson, Didier Payen de la Garanderie, Marie Cantier, Candice Sabben, Liliane Louedec, Sandrine Delbosc, Clément Journé, Phalla Ou, Isabelle Klein, Françoise Chau, Agnes Lefort, Jean-Philippe Desilles, Jean-Baptiste Michel, Mikaël Mazighi, Omar Ben Hadj Salem, Sophie Demeret, Francis Bolgert, Tarek Sharshar, David Grabli, Safa Arib, Ilaria Alice Crippa, Alexis Soummer, Nicolas Engrand, Pierre Guedin, Sorin Aldea, Charles Cerf, Victoire Desailly, Pierre Pasquier, Patrick Brun, Damien Roux, Gwendoline Latournerie, Laetitia Kasprzyk, Vincent Grosjean, Amine Latreche, Pierre Habert, Stephane Huot, Timon Jobin, Antoine Tesnière, Didier Dreyfuss, Jean-Damien Ricard, Alexandre Mignon, Stéphane Gaudry, François-Xavier Laithier, Antoine Kimmoun, Tahar Chouihed, Stéphane Albizzati, Edoardo Camenzind, Fabrice Vanhuyse, Bruno Levy, Martin Cour, Fabienne Venet, Romain Hernu, Julie Demaret, Guillaume Monneret, Laurent Argaud, Florence Dumas, Lionel Lamhaut, Julien Rosencher, Frédéric Pène, Olivier Varenne, Pierre Carli, Xavier Jouven, Christian Spaulding, Alain Cariou, Guillaume Geri, Franck Bonnetain, Eloi Marijon, Jean Philippe Empana, Adrien Mirouse, Matthieu Resche-Rigon, Julien Mayaux, Antoine Rabbat, Anne Pascale Meert, Dominique Benoit, Fabrice Bruneel, Elie Azoulay, Claire Dupuis, Carole Schwebel, Stéphane Ruckly, Dany Goldgran-Toledano, Guillaume Marcotte, Antoine Lafarge, Claire Pichereau, Igor Theodose, Marion Scotto, Delphine Kemlin, Etienne Ghrenassia, Benoît Schlemmer, Damien Vimpere, Lionel Galicier, Damien Contou, Emmanuel Guérot, David Grimaldi, Sylvie Ricome, Eric Maury, Gaëtan Plantefève, Armand Mekontso Dessap, Christian Brun-Buisson, Nicolas de Prost, Bruno-Pierre Dubé, Julie Delemazure, Martin Dres, Ludivine Rousseau, Xavier Drouot, Véronique Diaz, Yohann Rebollar, Jean-Pierre Frat, Arnaud W Thille, , Dalinda Ait Aissa, Pierre Coquet, Jean Ruiz, Fabrice Ferre, Lucille Hoarau, Béatrice Riu-Poulenc, Benoit Bataille, Stein Silva, Jean-Luc Baudel, Naïke Bigé, Jalel Tahiri, Vincent Dubée, Bertrand Guidet, Hafid Ait-Oufella, Liu Jinglun, Feng Shen, Xavier Monnet, Sébastien Bailly, Olivier Leroy, Philippe Montravers, Jean-Michel Constantin, Hervé Dupont, Didier Guillemot, Olivier Lortholary, Pierre-François Perrigault, Jean-Pierre Gangneux, Keyvan Razazi, Armand Mekontso-Dessap, Chloe Jansen, Marie Lecronier, Valade Sandrine, Jean-Paul Mira, Sophie Blein, Nathalie Marin, Christophe Rousseau, Julien Charpentier, Alexandre Pachot, Sami Hraiech, Julien Bordes, Lamballerie Xavier De, Jean-Louis Mège, Jean-Marie Forel, Christophe Guervilly, Mélanie Adda, Didier Raoult, Laurent Papazian, Nancy Kentish-Barnes, Zoé Cohen-Solal, Nancy Kentish-Barnes, Virginie Souppart, Lionel Kerhuel, Carole Haubertin, Isabelle Exbrayat, Elodie Rozières, Audrey Argain, Agnès Suc, Michel Vignes, Pierre Cougot, Olivier Fourcade, Elodie Brunel, Jonathan Messika, Florence Tubach, Emeline Dubief, Blandine Pasquet, Sylvie Guillo, Charlotte Pierron, Marion Grimaud, Caroline Farnoux, Amélie Maillard, Maxens Decavèle, Hélène Prodanovic, Ahmed Idbaih, Agusti Alentorn, Jean-Yves Delattre, Etienne De Montmollin, Noelle Brule, Marie Conrad, Frédéric Dailler, Jean-Christophe Navellou, Mikael Alves, Jean-Marie Tonnelier, Stephane Ruckly, Géraldine Picard, Véronique Rogemond, Jérôme Honnorat, , Chiara Marzorati, Christine Lebert, Pierre Perez, Giuseppe Citerio, Stéphane Legriel, Simona Tripon, Maxime Mallet, Marika Rudler, Francoise Imbert-Bismut, Dominique Thabut, Emmanuel Canet, Stanislas Faguer, Anne-Sophie Moreau, François Barbier, Sybille Merceron, Christophe Guitton, Francois Labadie, Virginie Lemiale, Etienne Faucher, Kada Klouche, Sylvie Chevret, , Stéphanie Ragot, Remi Coudroy, Thierry Boulain, Angéline Jamet, Alain Mercat, Laurent Brochard, Antoine Roux, Virginie Lemiale, Guillaume Franchineau, Nicolas Brechot, Guillaume Lebreton, Guillaume Hekimian, Ania Nieszkowska, Pascal Leprince, Jean Louis Trouillet, Alain Combes, Matthieu Schmidt, Loïc Barrot, Gaël Piton, Michael Bailey, Rakshit Panwar, Nicolas Belin, François Belon, Cyrille Patry, Mathilde Grandperrin, Claire Chaignat, Guylaine Labro, Bérengère Vivet, Gilles Capellier, Thomas Daix, Estelle Guérin, Elsa Tavernier, Emmanuelle Mercier, Valérie Gissot, Christine Vallejo, Bruno François, , Céline Ravry, Nicolas Pichon, Catherine Chapellas, Anne-Laure Fedou, Antoine Galy, Marie-Cécile Ploy, Olivier Barraud, Philippe Vignon, Aurelie Thooft, Raphael Conotte, Jean-Marie Colet, Matthieu Le Dorze, Virginie Tarazona, Caren Brumpt, Hélène Moins-Teisserenc, Fabrice Uhel, Imane Azzaoui, Murielle Gregoire, Céline Pangault, Joëlle Dulong, Luc Cynober, Mikaël Roussel, Yves Le Tulzo, Karin Tarte, Julien Demiselle, Johann Auchabie, Pierre François Dequin, Nicolas Chudeau, François Fourrier, Steven Grange, Lise Piquilloud, Alexandre Lautrette, Sonia Boyer, Julien Letheulle, Nicolas Lerolle, Anne Sophie Truche, Christophe Clec'h, Philippe Zaoui, Virginie Laurent, Dany Goldgran Toledano, Sophie Perinel Ragey, Antoine Gros, Anne Sylvie Dumenil, Samir Jamali, Michaël Darmon, , Mikhael Chouraqui, Antoine Dewitte, Brigitte Chastel, Pauline Carles, Catherine Fleureau, Olivier Joannes-Boyau, Alexandre Ouattara, Adrien Joseph, Maïté Garrouste-Orgeas, Adeline Max, Talia Lerin, Charles Grégoire, Martin Kloeckner, Cédric Bruel, Sandie Brochon, Francois Philippart, Emmanuelle Pichot, Clara Simons, Andrew Flint, Cécile Aubron, Rinaldo Bellomo, David Pilcher, Allen Cheng, Colin Hegarty, Anthony Martinelli, Benjamin Howden, Michael Reade, Zoe Mcquilten, Cédric Bretonnière, Daniel Villers, , , M Soares, Frédéric Gonzalez, François Vincent, , Clémence Fauché, Samuel Gay, Olivier Skowron, Albrice Levrat, Didier Dorez, Maxens Decavèle, Arnaud Foucrier, Sebastian Pease, Tobias Gauss, Catherine Paugam, Julie Gorham, Lieveke Ameye, Marianne Paesmans, Thierry Berghmans, Jean-Paul Sculier, Anne-Pascale Meert, Pauline Deras, Orianne Martinez, Pascal Latry, Xavier Capdevila, Jonathan Charbit, J Jaubert, Celia Etiennar, Lucie Ginoux, Jean-Luc Sebbah, Hakim Haouache, Gilles Dhonneur, Chaigar Mohammed Cheikh, I Moussaid, O Ghazaoui, Kamal Belkadi, S El Youssoufi, S Salmi, Laure Pajot, Benjamin Zuber, Michael Darmon, Jean Pierre Bedos, , Benoit Dupont, Axelle Eugène, Françoise Galateau-Sallé, Baptiste Michard, Benjamin Lebas, Alexandra Boivin, Max Guillot, Marie-Line Harlay, Ralf Janssen-Langenstein, Maleka Schenck, Bernard Ellero, Marie-Lorraine Woehl-Jaegle, Camille Besch, Vincent Castelain, Philippe Bachellier, Francis Schneider, Christophe Camus, Fawzi Saliba, Bernard Goubaux, Agnès Bonadona, Laurence Lavayssiere, Alice Quinart, Olivier Barbot, Sebastien Dharancy, Bertrand Delafosse, Helene Barraud, Arnaud Galbois, Benoit Veber, Sophie Cayot, Bruno Souche, Clara Locher, , Olivier Roux, Francesco Figorilli, Antonella Putignano, Pauline Houssel, Claire Francoz, Emmanuel Weiss, Banwari Agarwal, Rajiv Jalan, François Durand, Hassen Ben Ghezala, Rebeh Daoudi, Moez Kaddour, Hatem Ghadhoune, E Rachedi, J Guissouma, A Ben Slimene, W Azzeza, H Brahmi, H Elghord, Ahmed Youssef Kada, Radia Chikh, Roza Slimani, Kheireddine A Bouyoucef, Kais Regaieg, Chtara Kamilia, Najeh Baccouche, Olfa Turki, Anis Chaari, Hmida Chokri Ben, Mounir Bouaziz, Fatma Kaaniche Medhioub, Manel Zekri, Kais Rgieg, Chokri Bhimada, Bouaziz Mounir, Chaigar Mohammed Cheikh, Elodie Lang, Stephane Welschbillig, Mathilde Perrin, Jean-Michel Devys, Soumia Benbernou, Houria Mokhtari-Djebli, Sofiane Ilies, Khalida Bouyacoub, Abdelkader Azza, Elie Zogheib, Joseph Nader, Léonie Villeret, Mathieu Guilbart, Patricia Besserve, Thierry Caus, Ciro Mastroianni, Francesca Santi, Guillaume Hékimian, Leprince Pascal, Jean Chastre, Virginie Perrier, Benjamin Deniau, Fanny Klasen, Jean Pierre Ponthus, Polysie Ngasseu, Virginie Amilien, Elise Barsam, Pierre Lehericey, Martial Tchir, Jean Francois Georger, Bérénice Puech, David Vandroux, Arnaud Roussiaux, Dominique Belcour, Cyril Ferdynus, Olivier Martinet, Julien Jabot, Marion Fresco, Gaëlle Demeilliers-Pfister, Véronique Merle, Valéry Brunel, Bertrand Dureuil, Sébastien Leydier, Isabelle Clerc-Urmes, Jérémie Lemarie, Charles-Henri Maigrat, Aurélie Cravoisy-Popovic, Damien Barraud, Lionel Nace, Sébastien Gibot, Nelly Agrinier, Pierre-Edouard Bollaert, Jean-Louis Daban, Mathieu Boutonnet, Guillaume Dumas, Elisabeth Falzone, Patrick Jault, Bernard Lenoir, Joseph Nsiala Makunza, Nathalie Mejeni, Amélie Mazaud, Sébastien Béague, Anne-Flore Rousselle, Alain Durocher, , Pauline Perez, Alexandra Grinea, Naoures Bedoui, Alina Stoian, Loredana Baboi, Florent Gobert, Hodane Yonis, Romain Tapponier, Arnaud Bruyneel, Thierry Bonus, Grégory Cuvelier, Sharam Machayeckhi, Sandra Olieuz, Alexandre Legrand, Fatma Feki, Amira Jamoussi, Takoua Merhebene, Emna Braham, Asma Ghariani, Faouzi El Mezni, Leila Slim, Jalila Ben Khelil, Mohamed Besbes, Antoine Marchalot, Gaetan Beduneau, Dorothée Carpentier, Emmanuel Besnier, Gioia Gastaldi, Julien Abily, Marion Beuzelin, Mai-Anh Nay, Julie Mankikian, Virginie Hervé, Marie Soulie, Pierrick Cronier, Elie Kantor, Laura Federici, Marion Gilbert, Ilham Mezhari, Gérald Choukroun, Sophie Marque, Z Coppere, Jean-Pierre Fulgencio, Clarisse Blayau, Tai Pham, Michel Djibre, Matthieu Reffienna, Sébastien Lefort, Anne-Sophie Debue, Fabrice Daviaud, Sarah Cabon, , Zakaria Addou, Ali Douah, Mohamed Moussati, Kamel Belhabiche, Nabil Aouffen, Sylvie Soulier, Philippe Mauriat, Nadir Tafer, Guillaume Mortamet, Alessandro Amaddeo, Sonia Khirani, Brigitte Fauroux, Gennadiy Khanes, Olga Liutko, Svitlana Bidnenko, Emilie Doye, Nicolas Voirin, Delphine Maucort-Boulch, Karine Kolev-Descamp, Imane El Aouane, Aben Essid, Wallid Hammami, Isabelle Haegy, Jacques Bataille, Jean Bergounioux, Luc Morin, Samiran Ray, Graeme Maclaren, Simon Nadel, Martin Kneyber, Mark Peters, Koos Jansen, Daniele De Luca, Clare Wilson, Luregn Schlapbach, Pierre Tissières, Anne-Claire Girard, Elodie Savajols, Antoine Burguet, Denis Semama, Stephanie Litzler-Renault, Hana Fredj, Malek Hassouna, Youssef Zied El Hechmi, Mohamed Ali Cherif, Jerbi Zouheir, Ahmed Dernane, Fouad Bouakkaz, Lhoucine Ben Taleb, A Zeddine Mouhsen, Aissam Lyazidi, Jean-Christophe Marie Richard, Ahmed Mouhsen, Mohammed Harmouchi, Mourad Rattal, Matthias Huck, Thomas Leclerc, Nicolas Donat, Audrey Cirodde, Jean-Vivien Schaal, Yannick Masson, Clément Hoffmann, Laura Cerland, Ruddy Valentino, C Chabartier, Laurent Villain-Coquet, Jean-Louis Ferge, Y Brouste, Hossein Mehdaoui, Maha Louriz, Naoufal Madani, Fatiha Amlaiky, Tarek Dendane, Khalid Abidi, Aicha Zekraoui, Amine Ali Zeggwagh, Redouane Abouqal, Affra Brahim, Fehmi Ferhi, Mohamed Amine Bouslama, Khaled Benjazia, Abid Zeineb, Dhaouadi Mahassen, Julien Cadiet, Marine Ferron, Valentine Prat, Angelique Erraud, Virginie Aillerie, Mathieu Mevel, Amandine Grabherr, John C Chatham, Chantal Gauthier, Benjamin Lauzier, Bertrand Rozec, Jeremie Joffre, Xavier Loyer, Jean-Rémi Lavillegrand, Lynda Zeboudj, Ludivine Laurans, Bruno Esposito, Alain Tedgui, Ziad Mallat, Chaojie Wei, Narimane Al Kattani, Huguette Louis, Sophie Orlowski, Pierre-Louis Tharaux, Mélanie Burban, Grégory Meyer, Anne Olland, Blandine Yver, Florence Toti, Valérie Schini-Kerth, Alexandra Monnier, Pierrick Leborgne, Ferhat Meziani, Thomas Clavier, Mulder Paulus, Hélène Castel, Vincent Richard, Stéphanie Pons, David Skurnik, Sophie Six, Karim Jaffal, Clara Vigneron, Audrey Large, Julien Bador, Serge Aho, Sebastien Prin, Yosr Touil, Soufia Ayed, Habiba Sik Ali, Najla Tilouch, Houda Mateur, I Talik, Rim Gharbi, Mohamed Fekih Hassen, Souheil Elatrous, Isabelle Patry, Xavier Bertrand, Jean-Ralph Zahar, Wafa Essaied, Martin Wolkewitz, Mickaël Soued, Fabrice Cook, David Lobo, Roman Mounier, Aurélie Emirian, Jean Winoc Decousser, Mohamed Toufik Slaoui, Abdellatif Benslama, Dorothée Valance, Nicolas Allou, Jérôme Allyn, Elodie Jean-Bart, Floriane Bel, Fabienne Morey, Nicholas Sedillot, Lucie Biard, Richard Galliot, Romain Zunarelli, Bernard-Alex Gauzere, Jean-Charles Cartier, Thomas Jouve, Marie-Noëlle Hilleret, Rebecca Hamidfar-Roy, Claire Ara-Somohano, Clémence Minet, Aline Pourcelet, Jean-Michel Hougardy, Pierre Defrance, Louis De Laforcade, Alexandre Boyer, Didier Gruson, Benjamin Clouzeau, Najah Hajjam, Houda Nasri, Hamdi Doghri, Nicolas Mongardon, Eric Levesque, Marie-Anaïs Bastide, Jack Richecoeur, Eric Frenoy, Christian Lemaire, , Frédérique Schortgen, Sebastien Preau, Franck Ehooman, Claire Montlahuc, Jean Bardon, Nicolas Postel-Vinay, Mehdi Lafi, Frédéric Jacobs, Dominique Prat, Matthieu Le Meur, Guy Moneger, Nadège Demars, Pierre Trouiller, Noémie Tencé, Inès Zaien, Martine Wolf, Jérôme Allardet-Servent, Melissa Lebsir, Christian Dubroca, Mireille Portugal, Matthias Castanier, Thomas Signouret, Rettinavelou Soundaravelou, Anne Lepidi, Philippe Halfon, Jean-Marie Seghboyan, Camille Gamblin, Nadia Benturquia, Olivier Roussel, Lucie Chevillard, Patricia Risede, Jacques Callebert, Messaouda Khelfa, Youssef Blel, H Thabet, Nozha Brahmi, M Amamou, A Lillo- Le Louët, F Baud, C Le Beller, B Vivien, L Soufir, P Carli, H Le Louët, Fatma Essafi, Nasreddine Foudhaili, Abdelaziz Ben Slimen, Rami Jabla, Hedia Hammed, Mahdi Marzouk, Nesrine Boujelbene, Fahmi Dachraoui, Asma Hachani, Saousen Ben Abdallah, Hend Ben Lakhal, Chaima Ghribi, Imen Ben Ali, Imen Abdellaoui, Lamia Ouanes-Besbes, Fekri Abroug, Suela Demiri, Christine Lorut, Daniel Luu Van Lang, Aurélie Lefebvre, Marco Alifano, Jean-Francois Reignard, Marc Samama, Daniel Dusser, Nicolas Roche, François Réminiac, Cassandre Landel, Samuel Gensburger, Thomas Bocar, Lydiane Mordier, Marion Philippe, Déborah Le Pennec, Laurent Vecellio, Stephan Ehrmann, Laurent Poiroux, David Thevoz, Julien Simons, Jean Roeseler, Anthéa Loiez, Stéphanie Gérard, Nicolas Dousse, Sylvie L'hotellier, Elodie Baumgarten, Stéphanie Borschneck, Fatima Kharcha, Cécile Ghander, Christophe Tresallet, Etienne Puymirat, Jean-Yves Fagon, Philippe Aegerter, Jean-Luc Diehl, Caroline Hauw-Berlemont, Gilles Chatellier, Nicolas Danchin, Nadia Aissaoui, Nadia Aissat, R Bernard, Julien Amour, Adrien Bouglé, Charles Vidal, Djavidi Nima, Varnous Shaida, Amandine Dorget, Nicolas Bréchot, Rabi Toufiki, Youssef Mouaffak, Ahmed Rhassan El Adib, M Amine, S Moumine, Marie Jonard, Anne Sophie Ducloy-Bouthors, Pierre Bouju, Nicolas Barbarot, Arnaud Gacouin, Pierre Fillatre, Guillaume Grillet, Angélique Goepp, Anne-Laure Clairet, Samuel Limat, Christian Cornette, Amira Fatnassi, Chiheb Romdhani, Walid Sammoud, Iheb Labbene, Mustapha Ferjani, Hind Taibi, Ijlal Elatiqi, A Iraqui, Rachid Cherkab, Wafae Haddad, Chafik Elkettani, Lahoucine Barrou, Fabien Cave, Nicolas Lerolle, Pierre Louis Doutrellot, Benoit Vaysse, M Inan, K Khelfoun, M Nasserallah, Julien Maizel, C Legrand-Monteil, S Tasseel-Ponche, Benjamin Kowalski, Anne Guaguere, Claire Boulle-Geronimi, Juliette Masse, Clément Vanbaelinghem, Patrick Herbecq, Amel Mokline, Syrine Draief, Lazhari Gharsallah, Imen Rahmani, Bahija Gasri, Sofiene Tlaili, Rym Hammouda, Amen Allah Messadi, Philippe Michel, Bruno Gelée, Fouad Fadel, Marie Thuong, Sandra Ait-Aoudia, Salima Laddi, Mohamed-Mohcen Sahraoui, Michel Muller, Anna Faucher, Bertrand Hermann, Caroline Hauw Berlemont, Michel Arnaout, Julie Busson, Julie Dhumeaux, Nicole Ericher, Pierre Lucas, , Magalie Dumas, Celine Chapelle, Benedicte Philippon-Jouve, Jerome Morel, Pascal Beuret, Côme Bureau, Tymothée Poitou, , Remi Coudroy, Philippe Petua, Hassen Ben Ghezala, Albert Prades, Marion Basty, Clément Monet, Benjamin Mounet, Emmanuel Futier, Audrey Leroux, Xavier Oudinot, Marc Laurent, Islem Ouanes, Sebastien Jochmans, Jean-Emmanuel Alphonsine, Ly Van Vong, Nathalie Rolin, Oumar Sy, Jean Serbource-Goguel, Olivier Ellrodt, Mehran Monchi, Mabrouk Bahloul, Turki Olfa, Benhamida Chokri, Hedi Chelly, Amélie Trichot, Gwenhaël Colin, Isabelle Vinatier, Konstantinos Bachoumas, Jean-Claude Lacherade, Maud Fiancette, Aurélie Joret, Aihem Yehia, Matthieu Henry-Laguarrigue, Laurent Martin-Lefèvre, Keyvan Razazi, Mathieu Surenaud, Alexandre Bedet, Aurelien Seemann, Sophie Hüe, Raphaël Clere-Jehl, Anne-Laure Charles, Bernard Geny, Pascal Bilbault, Simon Bourcier, Gabriel Lejour, Simon Bourcier, Pierre Yves Boêlle, Nemlaghi Safaa, Sylvie Paulus, Claire Flamens, Jean Neidecker, Jerome Rambaud, Cecile Allioux, Romain Guedj, Isabelle Guellec, Julia Guilbert, Pierre-Louis Leger, Maryne Demoulin, Amélie Durandy, Sandrine Jean, Ricardo Carbajal, Aurélie Morand, Laurent Zieleskiewicz, Olivier Brissaud, Stéphane Le Bel, Zoé Meresse, Michel Panuel, Laurent Thomachot, Marc Leone, Fabrice Michel, Anna Deho', Laïly Sadozai, Stéphane Dauger, Sonia Prot-Labarthe, Mathieu Genuini, Moulin Florence, Jean-Marc Treluyer, Sylvain Renolleau, Emmanuelle Chalavon, Rodrigue Dessein, Bruno Grandbastien, Sarah Pesin, François Dubos, Stéphane Leteurtre, Marie-Aude Puel, Marie Szulc, Anais Philippe, François Severac, Dominique Astruc, Pierre Kuhn, Philippe Desprez, Nabil Tabet Aoul, Benoît Colomb, Anne Marie Petion, Laurent Queudet, Solenn Remy, Mouaffak Youssef, Nadia Roumeliotis, Christian Dong, Geraldine Pettersen, Louis Crevier, Guillaume Emeriaud, Jérôme Naudin, Laetitia Abdallah, Marion Ganier, Karine Frannais, Dylia Douglas, Cecile Flusin, David Brossier, Redha Eltaani, Michaël Sauthier, Bernard Guillois, Jerome Rambaud, Michelle Larroquet, Alain Amblard, Noella Lode, Isabelle Casadevall, Katia Kessous, Hervé Walti, Christophe Poiré, Huixiong Chen, Bruno Megarbane, A M'rad, Sahar Habacha, Bassem Chatbri, A M'rad, Cyril Masniere, Bruno Megarbane, A M'rad, Samar Souissi, Hatem El Ghord, N Kouraichi, N Brahmi, Takoua Marhbène, Islam Mejri, Douha Lakhdar, Takoua T Merhabane, Hé la Maamouri, Oestreicher Charlotte, Helena Wegelius, Caroline Landelle, Jacques Schrenzel, Laurent Kaiser, Jérôme Pugin, Hind Belhadj, Paul Chanareille, Adélie Ladureau, Alice Sanna, Amélie Rolle, Bertrand Pons, Pascale Piednoir, Fanny Ardisson, Frédéric Martino, Thomas Bernos, Khalid Elkoun, Elie Elain, Roland Lawson, Matthieu Resh-Rigon, Sophie Belorgey, Guillaume Thiery, Caroline Hauw Berlemont, Cyprian Pricopi, Françoise Barthes, Thansya Doddie, Mj Nsiala, Nh Situakibanza, Be Amisi, Mj Kazadi, Ma Kilembe, Christophe Clement, François Lamontagne, Valérie Nocquet Boyer, Sébastien Naimo, Ronan Raulais, Emilie Genevois, Lucie Bouchoud, Filippo Boroli, Nour Abidi, Mohamed Abbas, Stefan Harbarth, Jérôme Pugin, Pierre-Emmanuel Charles, Caroline Dereux, Stanislas De Guillebon, Eloise Morisse, Julie France, Deborah Gasser, Philippe Badia, Walter Picard, P Corne, I De Boulastel, S Seguin, A Blasco, V Ledur, Olivier Jonquet, Paktoris-Papine Sophie, Margaux Artiguenave, Faten El Sayed, Florence Espinasse, Aurélien Dinh, Cyril Charron, Benjamin Lebas, Sophie Hatsch, Quentin Maestraggi, Anne-Florence Dureau, François Faitot, Dimitri Margetis, Odile Bouvet, Didier Chevret, Erick Denamur, Justine Simonet, Philippe Vest, Vincent Peigne, Severine Couffin, M Cheikh Bouhlel, Ahmed Khedher, Kaoula Meddeb, A Azouzi, Y Hamdaoui, Jihene Ayachi, W Brahim, Rania Bouneb, Mohamed Boussarsar, Nans Florens, Julie Varéon, Arnaud Malatray, Laurent Argaud, Pierre Dupland, Romain Vergier, Pauline Issaurat, Philippe Estagnasié, Pierre Squara, Alain Brusset, Vincent Génin, Ali Jendoubi, Rifka Jlassi, Bassem Hamrouni, Yahia Marzougui, Jihen Kouka, Salma Ghedira, Mohamed Houissa, Kaouther Dhifaoui, Zied Hajjej, Johanna Oziel, , Alexy Tran Dinh, Caroline Neulier, Marlène Amara, Nicaise Nebot, Gilles Troché, Nelly Breton, Sébastien Cavelot, Béatrice Pangon, Jacques Merrer, François Labaste, Jean-Marie Conil, Julia Grossac, Stéphanie Ruiz, Marion Grare, Vincent Minville, Bernard Georges, Guillaume Van Der Meersch, Philippe Karoubi, Christophe Huang, Helene Carbonne, Rishma Amarsy, Joaquim Mateo, Sophie Leloup Von Edelsberg, Christelle Vercheval, Pierre Damas, Chaker Bouguerra, Noura Naas, Joris Muller, Mickael Schaeffer, Pierre Tran Ba Loc, Stéphanie Deboscker, Marie-Line Harley, Thierry Lavigne, Jennifer Brunet, Bertrand Canoville, François Lellouche, Erwan L'her, Pierre Alexandre Bouchard, Mathieu Delorme, Tamer Elfaramawy, Benoit Gosselin, Sarah Guegan, Jean-Bernard Michotte, Enrico Staderini, Jonathan Dugernier, Rares Rusu, Giuseppe Liistro, Gregory Reychler, Mathieu Delorme, Mathieu Simon, Elmaati Essoukaki, Frédéric Duprez, Jean Bernard Michotte, Olivier Contal, Becem Trabelsi, Zied Hajjej, Hedi Garsallah, Zied Hajjej, Khaoula Harira, Cédric Rafat, Eric Mariotte, Caroline Le Jeune, Pascal Roy, Mauricette Michallet, Yoann Zerbib, François Baudin, François Blot, Caroline Bornstain, Stéphanie Gelinotte, Jean-Philippe Rigaud, Fabienne Tamion, Marie Bouteloup, Michaël Darmon, , H Nouira, Julie Boisramé-Helms, Su Degirmenci, Christine Kummerlen, Eugénie Delile, Pierre-Alain Thiébaut, Jean-Claude Do Rego, David Coquerel, Rémi Nevière, Laure Ichou, Nicolas Carbonell, Pierre-Emmanuel Rautou, Jean-Baptiste Nousbaum, Christophe Renou, Rodolphe Anty, Luce Landraud, Hafid Ait-Oufella, Remi Coudroy, Jean-Claude Lecron, , Michael Helary, Jonathan Paillot, Sebastien Pili-Floury, Sana Khedher, Amira Maoui, Asma Ezzamouri, Mohamed Salem, Lamia Kerdjana, Mihaela Dumitrescu, Olivier Mimoz, Bertrand Debaene, Virginie Migeot, Claire Dahyot-Fizelier, Sana Khedher, Amira A Maoui, Benoit Champigneulle, Lara Zafrani, Jean-Baptiste Lascarrou, Floriane Lissonde, Aurélie Le Thuaut, Jean Reignier, Laura Platon, Jerôme Lambert, David Lagier, Jeanpaul Brun, Antoine Sannini, Laurent Chow-Chine, Magali Bisbal, Marion Faucher, Djamel Mokart, Leï la Mourtada, Lemiale Virgnie, Alexandre Gaudet, Erika Parmentier-Decrucq, Nathalie De Freitas Caires, Sylvain Dubucquoi, Philippe Lassalle, Daniel Mathieu, Jean-Christophe Richard, Romain Tapponnier, Luc Quintin, C Pichot, F Petitjeans, Antoine Guillon, Youenn Jouan, Daborah Breah, Fabien Gueugnon, Emilie Dalloneau, Thomas Baranek, Clemence Henry, Eric Morello, Jc Renauld, M Pichavant, Philippe Gosset, Y Courty, Patrice Diot, Mustapha Si-Tahar, Jean-Marc Tadié, Constance Vuillard, Béatrice La Combe, Pauline Ponsin, Guillaume Boddaert, Bertrand Grand, Yohan Baudoin, Stéphane Bonnet, Salah Snouda, Mohamed Fehmi Abbes, Imen Benchiekh, Chaigar Mohammed Cheikh, Ines Sedghiani, Neila Maaroufi, Jihane Belayachi, Leila Debono, Adrien Auvet, Lydie Nadal-Desbarats, Jacques Tankovic, Redouane Dahoumane, Hafid Ait Oufella, Georges Offenstadt, Amel Filali, Emmanuel Faure, Nicolas Van Grunderbeeck, Olivier Nigeon, H Bazus, Jihad Mallat, Didier Thevenin, Sophie Lempereur-Legros, Didier Ledoux, Monique Nys, Zied Hajjej, Jonathan Messika, Olivier Clermont, Alexandra Aubry, Romain Fernandes, Marion Venot, Sébastien Bailly, Cécile Garnaud, Muriel Cornet, Patricia Pavese, Luc Foroni, Sandrine Boisset, Daniè le Maubon, Islem Ouanes, Maha Abid, Hanane Ezzouine, Constant Aniolo Edith, Benjamin Sztrymf, Vincent Brunot, Jean-Emmanuel Serre, L Landreau, Mohamed Boussarsar, Islem Ouanes, Vanessa Jean-Michel, Francis Couturaud, Elizabeth Moore, Pierre-Yves Egreteau, Jean-Michel Boles, Jean-Etienne Herbrecht, Charlotte Kaeuffer, Anne Meyer, Amel Mokline, Khaouther Ben Arfi, Fabrice Lesage, Sylvie Séguret, Laurent Dupic, Laure De Saint Blanquat, Anne-Sophie Baptiste, Hugues Georges, Pierre-Yves Delannoy, Patrick Devos, Dolores Albarracin, A Ducousso-Lacaze, Julien Dufour, Séverin Cabasson, Anne Veinstein, Delphine Chatellier, René Robert, Vivien Hong Tuan Ha, Nicolas Lau, Lucie Mimoun, Xavier Forceville, Adel Maamar, Stéphanie Chevalier, Vlad Botoc, Stephane Rouleau, Arnaud Desachy, Sylvie Calvat, Charles Lafon, Christophe Cracco, Nicolas Van Grunderbeeck, J Temime, Perrine Molmy, G Gasan, Agathe Béranger, Hélène Chappuy, Pierre-Marie Bertrand, Alexandra Beurton, Laetitia Bodet-Contentin, Julie Boisramé-Helms, Pierre-éRic Danin, Elsa Dubois, Yasemin Karaca, Pierre Mora, Dominique Vodovar, , Yohan Desbrosses, Adrien Chauchet, Etienne Daguindau, Eric Deconinck, Akli Chermak, Marinne Baron, Laure Calvet, Anne Françoise Sapin, Bruno Pereira, Lucie Vettoretti, Jacques Lacroix, Lucy Clayton, Elham Sabri, Laurent Bardiaux, Pierre Tiberghien, Paul Hebert, , Etienne Lengliné, Marion Venot, Gérard Socié, Edith Borcoman, Katerina Rusinova, , Aurélien Sutra Del Galy, Mélanie Mercier, Jean-François Hamel, Tommy Raveau, Marie-Pierre Moles, Aline Clavert, Mathilde Hunault-Berger, Norbert Ifrah, Aline Schmidt-Tanguy, Serge Carreira, Sophie Lavault, Olivier Pallanca, Elise Morawiec, Isabelle Arnulf, Thomas D'humières, Cédric Carrié, Chloé Gisbert-Mora, Eline Bonnardel, Matthieu Biais, Gilles Hilbert, Côme Bureau, Thomas Joannon, Aude Marincamp, Jean-Daniel Chiche, Alexis Ferre, Daniel Lichtenstein, Gilbert Meziere, Martin Dres, Céline Gonzalez, Philippe Vignon, Olfa Hamzaoui, Thomas Geffriaud, François Leleu, Julien Maizel, Florence Boissier, Elise Cuquemelle, Pascal Lim, R Amara, Mohamed Boussarsar, Julie Léger, Christophe Jacob, Koceila Bouferache, Philippe Vignon, Claire Ragot, Laure Corradi, Julien Maizel, Laure Maurice, S Julliand, Anna Deho, Fleur Le Bourgeois, Aurelien Jacquot, Frederic Valla, Flavie Letois, , Alexandre Salvadori, Gaia Ottonello, Stéphane Blanot, Juliette Montmayeur, Gilles Orliaguet, Khalil Tarmiz, Flora Habas, Julien Baleine, Julia Lebouhellec, Clementine Combes, Maryline Chomton, Philippe Jouvet, Bruno Ranchin, Marie Alice Macher, Théophile Gaillot, , Mabrouk Bahloul, Murielle Moine, François Xavier Ageron, Claire Jannel, Thierry Debillon, Isabelle Wroblewski, Matthieu Duprey, Vincent Jarlier, Charles-Edouard Luyt, Sébastien Bailly, Thomas Longval, David Schnell, Christophe Padoin, Yves Cohen, Amel Mokline, Emna Gaies, Sameh Triki, Anis Klouz, Mouhamed Moussa, Flavie Desrumaux, Faten May, Marion Perrin, Jean-Claude Nguyen, Kelly Tiercelet, Julien Fournier, Mélanie Cherin, Marie Dominique Kitzis, Benoit Misset, Cyrille Mathien, Antoine Poidevin, Luis Donatti, Joy Mootien, Luis Pinto, Mathieu Egard, Gokhan Bodur, Guillaume Barberet, Carmen Ionescu, Frederique Ganster, Philippe Guiot, Khaldoun Kuteifan, Alain Mpela, Jonathan Chelly, Laurent Guérin, Romain Persichini, Thomas Hullin, Nicolas Deye, Pierre Aubertein, Marine Paul, Wulfran Bougouin, Claudio Sandroni, Olivier Passouant, Guillaume Geri, Jean-François Llitjos, Camille Chenevier-Gobeaux, Frederic Batteux, Jean-François Llitjos, Ludovic Drouet, Sebastian Voicu, Patrick Henry, Jean-Guillaume Dillinger, Wulfran Bougouin, Dabor Resiere, A L Dessoy, Benjamin Soyer, Valérie Faivre, Charles Damoisel, Benjamin Soyer, Laure Stiel, Anne-Cécile Galoisy, Laurent Mauvieux, Fatiha Zobairi, Eduardo Angles-Cano, Laure Stiel, Caroline Piau, Jean-Marc Tadié, Thomas Daix, Robin Jeannet, Jean Feuillard, Lucie Jolly, Amir Boufenzer, Kevin Carrasco, Marc Derive, Sebastien Gibot, Hamid Merdji, Nadia Belaidouni, Julie Toubiana, Yann L'Hermitte, France Woimant, Catherine Oppenheim, Christophe Couvreur, François Dolveck, Magali Devriese, Sophie Dupeyrat, Patrick Ray, Guillaume Lefevre, Muriel Fartoukh, Nicolas Roothaer, Amélie Carpentier, Fabien Vaniet, Antoine Maisonneuve, Eric Wiel, Sébastien Canu, Emmanuelle Hammad, Francois Antonini, Marion Poirier, Coralie Vigne, Malik Haddam, Julie Alingrin, Laurence Dangers, Gilles Mangiapan, Isabelle Huet, Xavier Dhalluin, Nathalie Bautin, Jean Jacques Quiot, Corinne Appere De Vecchi, Cécile Chenivesse, Khalil Tarmiz, Fatma Kaaniche Medhioub, Mariem Smaoui, Chaigar Mohammed Cheikh, E El Alami, Nicolas Weiss, Fanny Mochel, Damien Galanaud, Louis Puybasset, , Marion Lodey, Elsa Guiller, Nicolas Weiss, Stein Silva, Corine Vuillaume, Francesco De Pasquale, Jean Francois Demonet, Fabrice Sinnah, Marie Amelie Dalloz, Marie Pia D'ortho, Anny Rouvel-Tallec, David Couret, Aurélie Catan, Brice Nativel, Cynthia Planesse, Nicolas Diotel, Olivier Meilhac, Fabian Roy-Gash, Christophe Lebard, Anne-Gaelle Si Larbi, Virginie Gaudin, France Bonnin, Oceane Sultan, Cecile Hoc, Emmanuel Mathieu, Bertrand Lapergue, Frederic Bourdain, Margot Caron, Antoine Parrot, Vincent Labbe, El Mahdi Hafiani, Christophe Quesnel, Stephanie Genay, Bertrand Décaudin, Sabine Ethgen, Pascal Odou, Gilles Lebuffe, Stéphane Gaudry, Cécile Aubron, Zoe Mcquilte, Maïté Garrouste-Orgeas, Lilia Soufir, Bernard Allaouchiche, Bruno Verdière, Martine Nyunga, Noémie Banaias, Delphine Colling, Marie Kauv, Erik Blondeau, Islem Ouanes, Edouard Auclin, Caroline Haw-Berlemont, Julien Taieb, Stéphane Oudard, Genevieve Morissette, Wassim Kechaou, Catherine Litalien, Aïcha Merouani, Véronique Phan, Josée Bouchard, Julie Starck, Nelly Briand, Philippe Sachs, François Angoulvant, Julie Sommet, L Holvoet, M Benkerrou, Lélia Dreyfus, Fabienne Bordet, Sandrine Touzet, Angélique Denis, Julien Le Coz, Gérard Chéron, Rima Nabbout, Geraldine Patteau, Claire Heilbronner, Philippe Hubert, Mehdi Oualha, Nabil Tabet Aoul, Benjamin Crulli, Baruch Toledano, Nancy Poirier, Suzanne Vobecky, Hosni Khouadja, René Robert, M Vinet, Camille Vinclair, Julie Boisramé-Helms, François Beloncle, Peter Radermacher, Pierre Asfar, Elisabeth Coupez, Julien Bohé, Cláudia Righy Shinotsuka, Pietro Caironi, Paola Villois, Vito Fontana, Jacques Creteur, Franck Pourcine, Ly Vong, Claire Marie Weyer, Benoit Akando, Razach Abdallah, Morgane Wetzstein, Julien Maizel, Nadiejda Antier, Yasmina Serroukh, Karim Zouaoui Boudjeltia, Anne Joosten, Alexandre Rousseau, Xavier Delabranche, Lélia Grunebaum, , Xavier Delabranche, Yoganaden Mootien, Rostane Gaci, Jean-Romain Garric, Agathe Delbove, Cédric Darreau, , Auguste Dargent, Agnès Soudry-Faure, , Marc Pineton De Chambrun, Pierre Demondion, Jean-Christophe Blanchard, Sydney Chocron, Nicolas Meneveau, Filippo Corsi, Pierre-Emmanuel Meynieu, Benjamin Repusseau, Arnaud Germain, Guillaume Baudry, Lucie Hierle, Guillaume Besch, Guillemette Thomas, Nadim Cassir, Stéphanie Dizier, Antoine Roch, Grégoire Trebbia, Kiruba Govindaradjou, Jérôme Devaquet, Clément Picard, François Parquin, Morgan Leguen, Marie-Louise Felten, Edouard Sage, Alain Chapelier, Maxens Decavèle, Michael Duruisseaux, Jocelyne Fleury, Martine Antoine, Marie-France Carette, Marie Wislez, Claire Givel, Constance De Margerie-Mellon, Eric De Kerviler, Yacine Tandjaoui-Lambiotte, Olivia Freynet, Antoine Kimmoun, Elisabeth Baux, Vincent Das, Patrice Talec, Nadia Anguel, Guillaume Louis, Nicolas Girerd, Pauline Tallon, Alice Hadchouel-Duvergé, Nadège Salvi, Pascale Cairet, Christophe Delacourt, Blandine Lefebvre Blandine, Laurence Beraud, Zoé Coppere, Antonin Lamaziere, François Lionnet, Muriel Fartoukh, Samuel Lehingue, Xavier D'journo, Forel Jean-Marie, Ronan Thibault, Anne-Marie Makhlouf, Aurélien Mulliez, Cristina Gonzalez, Sylvain Dadet, Gintautas Kekstas, Jean-Charles Preiser, Kozjek Nada Rotovnik, Isabel Ceniceros Rozalen, Kinga Kupczyk, Zeljko Krznaric, Noël Cano, Claude Pichard, , Bénédicte Gaillard- Le Roux, Corinne Jotterand, Shancy Rooze, Clemence Moullet, Aurélia Henin, Florence Ettori, Christophe Zemmour, Jean Marie Boher, Michel Arnaout, Audrey Feltry, Salah Adel Ben, Juliette Audibert, Alexandre Conia, Olivier Gontier, Mouldi Hamrouni, Thierry Lherm, Abdelkader Ouchenir, Jérôme Rétif, Alain Proudhom, Chantal Lagardere, Stéphane Tissot, Pierre Kalfon, Lynn Sacre, Antoine Villa, Alaywa Khadija, Robert Garnier, Frederic Baud, Frederic Baud, Brigitte Vasset, Annette Heinzelman, Frederic Baud, Romain Jouffroy, Elsa Démarest Durand, Patricia Compagnon, Neila Maaroufi, A M'rad, Alia Jebri, Hassen Ben Ghezala, Céline Legout, Frederic Baud, Anne Castot-Villepelet, Sandrine Valade, Olivier Lesieur, Benjamin Delmas, Benoit Visseaux, Johana Cohen, Liem Binh Luong Nguyen, Caroline Morbieu, Charles Burdet, François-Xavier Lescure, Laurence Armand-Lefevre, Yazdan Yazdanpanah, Nadira Houhou-Fidouh, Marine Cazaux, Le Goff Jérôme, Veronique Meignin, David Boutboul, Philippe Rispail, Vincent Brunot, N Besnard, Patrice Ceballos, Annabelle Stoclin, Federico Rotolo, Muriel Wartelle, Yosr Hicheri, Sylvia Maillet, Elisabeth Chachaty, Jean-Pierre Pignon, Marion Venot, Mathieu Delorme, Emilie Bialais, Dupuis Julie, Laura Paoloni, Xavier Wittebolle, Cheryl Hickmann, Diego Castanares-Zapatero, Antoine Tordeur, Lise Colmant, Xavier Wittebole, Giuseppe Tirone, Pierre-François Laterre, Lorraine Ducroux, Claire Kemlin, Eric Moulton, Charlotte Rosso, Aymeric Le Neindre, Silvia Mongodi, Béaïd Bouhemad, Joana Rodrigues, Caroline Botteau, Frédéric Duprez, François Waroquier, Karel Christiaens, Frank Vantrimpont, Frédéric Duprez, Charbel Elkhawand, Frank Vermeesh
Emergency unit, C.H. Epicura, Hornu, Belgium.

PHYSICIANS ABSTRACTSO1 Impact of tracheal cuff shape on microaspiration of gastric contents in intubated critically ill patients: a multicenter randomized controlled study (BEST CUFF)Emmanuelle Jaillette, Christophe Girault, Guillaume Brunin, Farid Zerimech, Arnaud Chiche, Céline Broucqsault-Dedrie, Cyril Fayolle, Franck Minacori, Isabelle Alves, Stephanie Barrailler, Laurent Robriquet, Fabienne Tamion, Emmanuel Delaporte, Damien Thellier, Claire Delcourte, Alain Duhamel, Saad NseirO2 Bicarbonate versus saline for contrast-induced acute kidney injury prevention in critically ill patientsXavier Valette, Isabelle Desmeulles, Benoit Savary, Romain Masson, Amélie Seguin, Cédric Daubin, Bertrand Sauneuf, Jennifer Brunet, Pierre Verrier, Véronique Pottier, Marie Orabona, Désiré Samba, Gérald Viquesnel, Mathilde Lermuzeaux, Pascal Hazera, Jean-Luc Hanouz, Jean-Jacques Parienti, Damien Du CheyronO3 Neurally adjusted ventilatory assist in the early phase of weaning from mechanical ventilation: a multicenter randomized studyAlexandre Demoule, Marc Clavel, Camille Rolland-Debord, Sébastien Perbet, Nicolas Terzi, Achille Kouatchet, Florent Wallet, Hadrien Roze, Frédéric Vargas, Claude Guérin, Jean Dellamonica, Samir Jaber, Thomas SimilowskiO4 Very high volume hemofiltration with the Cascade system in septic shock patientsJean-Pierre Quenot, Christine Binquet, Christophe Vinsonneau, Saber-Davide Barbar, Sandrine Vinault,, Valérie Deckert, Stephanie Lemaire, Ali Ait Hssain, Rémi Bruyère, Bertrand Souweine, Laurent Lagrost, Christophe AdrieO5 Effect of rapid response systems on hospital mortality, a prospective interventional study and systematic reviewBoris Jung, Aurelien Daurat, Audrey De Jong, Gérald Chanques, Martin Mahul,, Marion Monnin, Nicolas Molinari, Samir JaberO6 Beta-lactams serum concentrations in critically ill cirrhotic patients: a matched control studyOlivier Lheureux, Eric Trepo, Maya Hites, Frederic Cotton, Fleur Wolff, Rudy Surin, Jacques Créteur, Jean-Louis Vincent, Thierry Gustot, Frederique Jacobs, Fabio Silvio TacconeO7 Systematic overdosing of oxa- and cloxacillin in severe infections treated in ICU: Risk factors and side effectsMathilde Neuville, Jean-François Timsit, Najoua El-Helali, Alban Le Monnier, Eric Magalhaes, Aguila Radjou, Roland Smonig, Jean-François Soubirou, Guillaume Voiriot, Romain Sonneville, Lila Bouadma, Bruno MourvillierO8 Amikacin peak concentrations in patients receiving extracorporeal membrane oxygenation (ECMO) support: a case-control studyElodie Gélisse, Mathilde Neuville, Etienne De Montmollin, Guillaume Voiriot, Jean-François Soubirou, Roland Smonig, Aguila Radjou, Eric Magalhaes, Lila Bouadma, Bruno Mourvillier, Jean-François Timsit, Romain SonnevilleO9 A high aminoglycoside regimen associated with renal replacement therapy for the treatment of multi-drug-resistant pathogensAlexandre Brasseur, Maya Hites, Sandrine Roisin, Frederic Cotton, Jean-Louis Vincent, Daniel De Backer, Frederique Jacobs, Fabio Silvio TacconeO10 Optimization of administration of vancomycin in septic patients: a prospective randomized studyValerie Van Ruychevelt, Eric Carlier, Michael Piagnerelli, Michel Vanhaeverbeek, Christine Danguy, Patrick BistonO11 Impact of elevated intra-abdominal pressure on the ability of dynamic parameters to predict fluid responsivenessSiu-Ming Au, Emmanuelle Begot, François Dalmay, Xavier Repessé, Gwenael Prat, Koceila Bouferrache, Michel Slama, Philippe Vignon, Antoine Vieillard-BaronO12 Passive leg raising for predicting fluid responsiveness: a systematic review and meta-analysisXavier Monnet, Paul Marik, Jean-Louis TeboulO13 Predicting volume responsiveness by using combined end-expiratory and end-inspiratory occlusion tests with echocardiographyMathieu Jozwiak, Jean-Louis Teboul, Christian Richard, Xavier MonnetO14 Early dynamic left intraventricular obstruction is associated with hypovolemia and hight mortality in septic shock patientsJean-Louis Chauvet, Shari El-Dash, Olivier Delastre, Bernard Bouffandeau, Dominique Jusserand, Jean-Baptiste Michot, Fabrice Bauer, Julien Maizel, Michel SlamaO15 Predictive factors for poor hemodynamic tolerance to fluid removal in ICU: the DepleRea studyFrançois Brazier, Pablo Mercado, Loay Kontar, Dimitri Titeca, Bertand De Cagny, Gaelle Bacari-Risal, Antoine Riviere, Michel Slama, Julien MaizelO16 High-flow nasal cannula: first-line treatment of noninvasive ventilation for infants with bronchiolitis. Applicability and risk factors for failureCamille Guillot, Claire Le Reun, Marie Lampin, Ahmed Sadik, Astrid Botte, Alain Duhamel, Stéphane LeteurtreO17 Is high-flow nasal cannula better than nasal continuous positive airway pressure for bronchiolitis management in pediatric intensive care unit?Aurélie Collins, Céline Kempeneers, Nathalie CajgfingerO18 Interest and risk of high-flow cannula during acute hypoxemic pneumonia in children: a retrospective studyCamille Ohlmann, Robin Pouyau, Fabien Subtil, Florent Baudin, Bruno Massenavette, Etienne JavouheyO19 Interest of high-flow nasal cannula (HFNC) versus nasal continuous positive airway pressure (nCPAP) during the initial management of severe bronchiolitis in infants: a multicenter randomized controlled trialChristophe Milesi, Sandrine Essouri, Robin Pouyau,, Jean-Michel Liet, Mickael Afanetti, Julien Baleine, Sabine Durand, Philippe Durand, Etienne Javouhey, Jean Christophe Roze, Didier Dupont, Gilles CambonieO20 Outcome of severe cerebral venous thrombosis in intensive care unit: a cohort studyBenjamin Soyer, Marco Rusca, Anne-Claire Lukaszewicz, Isabelle Crassard, Jean-Pierre Guichard, Damien Bresson, Didier Payen de la GaranderieO21 Brain lesion spectrum characterization in an experimental model of infective endocarditisMarie Cantier, Candice Sabben, Liliane Louedec, Sandrine Delbosc, Clément Journé, Phalla Ou, Isabelle Klein, Françoise Chau, Agnes Lefort, Jean-Philippe Desilles, Jean-Baptiste Michel, Romain Sonneville, Mikaël MazighiO22 Outcome of patients with Parkinson's disease admitted in intensive care unitOmar Ben Hadj Salem, Sophie Demeret, Alexandre Demoule, Thomas Similowski, Francis Bolgert, Tarek Sharshar, David GrabliO23 Cerebrospinal fluid glucose and lactate concentrations after subarachnoid hemorrhageSafa Arib, Ilaria Alice Crippa, Jacques Créteur, Jean-Louis Vincent, Fabio Silvio TacconeO24 Spontaneous angionegative subarachnoidal hemorrhage: neurological outcome based on a retrospective study of 68 patientsAlexis Soummer, Nicolas Engrand, Pierre Guedin, Grégoire Trebbia, Sorin Aldea, Charles CerfO25 Serious game evaluation of a one-hour training basic life support session for secondary school students: new tools for future bystandersVictoire Desailly, Pierre Pasquier, Patrick Brun, Damien Roux, Jonathan Messika, Gwendoline Latournerie, Laetitia Kasprzyk, Vincent Grosjean, Amine Latreche, Pierre Habert, Stephane Huot, Timon Jobin, Antoine Tesnière, Didier Dreyfuss, Jean-Damien Ricard, Alexandre Mignon, Stéphane GaudryO26 Refractory out-of-hospital refractory cardiac arrest treated by veno-arterial extracorporeal membrane oxygenation. A retrospective single-center experience from 2012 to 2015. Read More

CARECMO program (Cardiac ARrest Extra Corporeal Membrane Oxygenation)François-Xavier Laithier, Antoine Kimmoun, Tahar Chouihed, Stéphane Albizzati, Edoardo Camenzind, Fabrice Vanhuyse, Bruno LevyO27 Decreased monocyte HLA-DR expression after out-of-hospital cardiac arrestMartin Cour, Fabienne Venet, Romain Hernu, Julie Demaret, Guillaume Monneret, Laurent ArgaudO28 Is emergent PCI associated with a clinical benefit in post-cardiac arrest patients without ST-segment elevation pattern? Insights from the PROCAT II registryFlorence Dumas, Wulfran Bougouin, Guillaume Geri, Lionel Lamhaut, Julien Rosencher, Frédéric Pène, Jean-Daniel Chiche, Olivier Varenne, Pierre Carli, Xavier Jouven, Jean-Paul Mira, Christian Spaulding, Alain CariouO29 Predictors of long-term quality of life after cardiac arrest: insights from the Parisian registryGuillaume Geri, Florence Dumas, Franck Bonnetain,, Wulfran Bougouin, Benoit Champigneulle, Michel Arnaout, Pierre Carli, Eloi Marijon, Olivier Varenne, Jean-Paul Mira, Jean Philippe Empana, Alain CariouO30 Red blood cell transfusions in early resuscitation of severe sepsis and septic shock in patients with hematological malignanciesAdrien Mirouse, Matthieu Resche-Rigon, Virginie Lemiale, Djamel Mokart, François Vincent, Julien Mayaux, Antoine Rabbat, Martine Nyunga, Anne Pascale Meert, Dominique Benoit, Achille Kouatchet, Michaël Darmon, Fabrice Bruneel, Elie Azoulay, Frédéric PèneO31 Causal effect of transfusion on mortality and other adverse events among critically ill septic patients: an observational study with a marginal structural modelClaire Dupuis, Michaël Darmon, Carole Schwebel, Elie Azoulay, Romain Sonneville, Lila Bouadma, Roland Smonig, Yves Cohen, Stéphane Ruckly, Christophe Adrie, Dany Goldgran-Toledano, Sébastien Bailly, Guillaume Marcotte, Maïté Garrouste-Orgeas, Jean-François TimsitO32 Autoimmune hemolytic anemia in the intensive care unitAntoine Lafarge, Claire Pichereau, Sandrine Valade, Marion Venot, Akli Chermak, Igor Theodose, Marion Scotto, Delphine Kemlin, Claire Givel, Leïla Mourtada, Etienne Ghrenassia, Emmanuel Canet, Virginie Lemiale, Benoît Schlemmer, Elie Azoulay, Eric MariotteO33 Pre-ICU location, lead time bias and outcomes in patients with thrombotic microangiopathiesDamien Vimpere, Sandrine Valade, Marion Venot, Claire Pichereau, Akli Chermak, Virginie Lemiale, Emmanuel Canet, Lionel Galicier, Elie Azoulay, Eric MariotteO34 Septic shocks with no early etiological diagnosis: a multicenter prospective cohort study (the shock 24 study)Damien Contou, Damien Roux, Sebastien Jochmans, Remi Coudroy, Emmanuel Guérot, David Grimaldi, Sylvie Ricome, Eric Maury, Gaëtan Plantefève, Julien Mayaux, Armand Mekontso Dessap, Christian Brun-Buisson, Nicolas de ProstO35 Respective contribution of diaphragm and limbs muscles weakness on weaning from mechanical ventilation outcomeAlexandre Demoule, Bruno-Pierre Dubé, Julien Mayaux, Julie Delemazure, Thomas Similowski, Martin DresO36 Impact of sleep quality on the duration of weaning from mechanical ventilationLudivine Rousseau, Xavier Drouot, Véronique Diaz, Yohann Rebollar, Jean-Pierre Frat, Remi Coudroy, René Robert, Arnaud, W Thille, Groupe ALIVEO37 Integrative ultrasound assessment of lung, cardiac and diaphragm function during a successful weaning trial predicts postextubation distressDalinda Ait Aissa, Pierre Coquet, Jean Ruiz, Fabrice Ferre, Lucille Hoarau, Béatrice Riu-Poulenc, Benoit Bataille, Stein SilvaO38 ETCO 2 improved outcome prediction of mechanical ventilation weaningJean-Luc Baudel, Simon Bourcier, Claire Pichereau, Naïke Bigé, Jalel Tahiri, Vincent Dubée, Bertrand Guidet, Eric Maury, Hafid Ait-OufellaO39 Characteristics of 150 cases of weaning-induced pulmonary oedema and effects of diureticsLiu Jinglun, Feng Shen, Jean-Louis Teboul, Christian Richard, Xavier MonnetO40 Antifungal de-escalation was not associated with adverse outcome in critically ill patients treated for invasive candidiasisSébastien Bailly, Olivier Leroy, Philippe Montravers, Jean-Michel Constantin, Hervé Dupont, Didier Guillemot, Olivier Lortholary, Jean-Paul Mira, Pierre-François Perrigault, Jean-Pierre Gangneux, Elie Azoulay, Jean-François TimsitO41 Intensive care acquired pneumonia due to extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-PE) among patients with prior colonization: Frequency, risk factors and prognosisKeyvan Razazi, Armand Mekontso-Dessap, Chloe Jansen, Nicolas de Prost, Christian Brun-BuissonO42 Epidemiology, characteristics and outcomes of septic critically ill patients after the removal of a totally implantable venous-access portsMarie Lecronier, Valade Sandrine, Naïke Bigé, Nicolas de Prost, Damien Roux, Jean-Damien Ricard, Eric Maury, Julien Mayaux, Elie Azoulay, Alexandre Demoule, Martin DresO43 Genetic risk of Pseudomonas aeruginosa ventilator-associated pneumonia: the EXTENSE studyJean-Paul Mira, Sophie Blein, Nathalie Marin, Christophe Rousseau, Julien Charpentier, Jean-Daniel Chiche, Alexandre PachotO44 Cytomegalovirus reactivation enhances the virulence of a Staphylococcus aureus pneumonia in a mouse modelSami Hraiech, Julien Bordes, Samuel Lehingue, Lamballerie Xavier De, Jean-Louis Mège, Jean-Marie Forel, Christophe Guervilly, Mélanie Adda, Didier Raoult, Laurent PapazianO45 Families looking back: meaning-making after a decision to accept or refuse organ donation. A qualitative approachNancy Kentish-Barnes, Zoé Cohen-Solal, Elie AzoulayO46 The letter of condolence at the heart of family centered care. A qualitative approach of relatives' experienceNancy Kentish-Barnes, Zoé Cohen-Solal, Virginie Souppart, Elie AzoulayO47 Use of a children information booklet to support young relatives visiting a critically ill adult: impact on ICU practicesLionel Kerhuel, Carole Haubertin, Isabelle Exbrayat, Elodie Rozières, Audrey Argain, Agnès Suc, Michel Vignes, Pierre Cougot, Béatrice Riu-Poulenc, Stein Silva, Olivier Fourcade, Elodie BrunelO48 Withdrawal of life-support therapies reporting in ICU randomized controlled trial: Let us move to a transparent reporting-a systematic reviewJonathan Messika, Stéphane Gaudry, Florence Tubach, Emeline Dubief, Blandine Pasquet, Sylvie Guillo, Didier Dreyfuss, Jean-Damien RicardO49 Gasp during children end-of-life: healthcare providers' feelings and knowledgeCharlotte Pierron, Marion Grimaud, Caroline Farnoux, Amélie MaillardO50 Prognosis of malignant primary brain tumors in intensive care unitMaxens Decavèle, Nicolas Weiss, Hélène Prodanovic, Julien Mayaux, Ahmed Idbaih, Agusti Alentorn, Jean-Yves Delattre, Thomas Similowski, Alexandre DemouleO51 Impact of early immunomodulating treatment on outcome of adult patients with anti-N-methyl-D-aspartate receptor encephalitis requiring intensive care: a multicentre study with prospective long-term follow-upEtienne De Montmollin, Sophie Demeret, Noelle Brule, Marie Conrad, Frédéric Dailler, Nicolas Lerolle, Jean-Christophe Navellou, Carole Schwebel, Mikael Alves, Martin Cour, Nicolas Engrand, Jean-Marie Tonnelier, Stephane Ruckly, Géraldine Picard, Véronique Rogemond, Jean-François Timsit, Jérôme Honnorat, Romain Sonneville, ENCEPHALITICA study groupO52 Determinants of outcome in critically ill patients with hematological malignancy and central neurological failure: data from the TRIAL OH studyChiara Marzorati, Virginie Lemiale, Djamel Mokart, Frédéric Pène, Achille Kouatchet, Julien Mayaux, François Vincent, Martine Nyunga, Fabrice Bruneel, Antoine Rabbat, Christine Lebert, Pierre Perez, Dominique Benoit, Giuseppe Citerio, Elie Azoulay, Stéphane LegrielO53 Ammonemia predicts severity and outcome in cirrhotic patients with hepatic encephalopathy in ICUSimona Tripon, Maxime Mallet, Marika Rudler, Francoise Imbert-Bismut, Dominique Thabut, Nicolas WeissO54 Acute varicella zoster encephalitis admitted to the ICU: a case series of 47 patientsEmmanuel Canet, Adrien Mirouse, Romain Sonneville, Laurent Argaud, Stanislas Faguer, Keyvan Razazi, Claude Guérin, Pierre Perez, Anne-Sophie Moreau, Claire Pichereau, François Barbier, Sybille Merceron, Amélie Seguin, Julien Mayaux, Guillaume Geri, Christophe Guitton, Francois Labadie, Elie AzoulayO55 High-flow nasal cannula for acute respiratory failure in immunocompromised patientsVirginie Lemiale, Matthieu Resche-Rigon, Djamel Mokart, Frédéric Pène, Etienne Faucher, Christophe Guitton, Antoine Rabbat, Christophe Girault, Achille Kouatchet, François Vincent, Fabrice Bruneel, Martine Nyunga, Amélie Seguin, Kada Klouche, Sylvie Chevret, Elie Azoulay, Groupe de Recherche en Reanimation Respiratoire du patient d'Onc-hématologieO56 High-flow oxygen therapy through a nasal cannula in immunocompromised patients with acute hypoxemic respiratory failureJean-Pierre Frat, Stéphanie Ragot, Christophe Girault, Remi Coudroy, René Robert, Jean-Michel Constantin, Gwenael Prat, Thierry Boulain, Angéline Jamet,, Alain Mercat, Laurent Brochard, Arnaud, W. ThilleO57 Prospective validations of the PASTEIL score to assess the clinical pretest probability of Pneumocystis jirovecii pneumonia (PjP) in patients with hematologic malignancies (HMs) and acute respiratory failure (ARF)Elie Azoulay, Sylvie Chevret, Antoine Roux, Etienne Faucher, François Vincent, Antoine Rabbat, Achille Kouatchet, Frédéric Pène, Julien Mayaux, Pierre Perez, Martine Nyunga, Christophe Guitton, Fabrice Bruneel, Kada Klouche, Djamel Mokart, Virginie LemialeO58 Bedside contribution of electrical impedance tomography (EIT) to set mechanical ventilation for severe acute respiratory distress syndrome (ARDS) on extracorporeal membrane oxygenation (ECMO)Guillaume Franchineau, Nicolas Brechot, Guillaume Lebreton, Guillaume Hekimian, Ania Nieszkowska, Charles-Edouard Luyt, Pascal Leprince, Jean Louis Trouillet, Alain Combes, Matthieu SchmidtO59 Liberal oxygenation versus restrictive oxygenation in ICU patients: effects on proinflammatory cytokines, sRAGE and organ dysfunctions - results of an ancillary studyLoïc Barrot, Gaël Piton, Michael Bailey, Rakshit Panwar, Nicolas Belin, François Belon,, Cyrille Patry, Jean-Christophe Navellou, Mathilde Grandperrin, Claire Chaignat, Guylaine Labro, Bérengère Vivet, Gilles CapellierO60 Immature granulocyte level at the acute phase of sepsis, a potential prognostic marker of clinical deterioration. The Septiflux 2 multicenter trialThomas Daix, Estelle Guérin, Elsa Tavernier, Emmanuelle Mercier, Valérie Gissot, Christine Vallejo, Jean-Paul Mira, Christophe Guitton, Bruno François, Septiflux trial GroupO61 Analysis of microbiome and resistome using next-generation sequencing in urine samples from patients with sepsis, severe sepsis or septic shockCéline Ravry, Bruno François, Emmanuelle Begot, Nicolas Pichon, Catherine Chapellas, Anne-Laure Fedou, Antoine Galy, Marie-Cécile Ploy, Olivier Barraud, Philippe VignonO62 Patients metabolomic profiles at intensive care admissionAurelie Thooft, Raphael Conotte, Jean-Marie Colet, Patrick Biston, Michael PiagnerelliO63 Lymphocyte phenotype during severe sepsis and septic shockMatthieu Le Dorze, Virginie Tarazona,, Caren Brumpt,, Hélène Moins-Teisserenc,, Anne-Claire Lukaszewicz, Didier Payen de la GaranderieO64 Myeloid-derived suppressor cells expressing arginase-1 and IDO play a major role in immune dysfunction during septic shockFabrice Uhel, Imane Azzaoui,, Murielle Gregoire, Céline Pangault, Joëlle Dulong,, Luc Cynober,, Jean-Marc Tadié, Mikaël Roussel,, Yves Le Tulzo, Karin TarteO65 Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis admitted to the intensive care unit: a multicenter studyJulien Demiselle,, Johann Auchabie,, Julie Boisramé-Helms, Pierre François Dequin, Damien Du Cheyron, Michaël Darmon, Nicolas Chudeau, Guillaume Geri, René Robert, François Fourrier, Steven Grange, Christophe Guitton, Lise Piquilloud, Alexandre Lautrette, Sonia Boyer, Emmanuel Guérot, Julien Letheulle, Nicolas LerolleO66 Continuous renal replacement therapy versus intermittent hemodialysis: impact on mortality and renal recoveryAnne Sophie Truche, Michaël Darmon, Sébastien Bailly, Christophe Clec'h, Claire Dupuis, Benoit Misset, Elie Azoulay, Carole Schwebel, Lila Bouadma, Christophe Adrie, Guillaume Marcotte, Philippe Zaoui, Virginie Laurent, Dany Goldgran Toledano, Romain Sonneville, Bertrand Souweine, Jean-François TimsitO67 Hospital survival and need of renal replacement therapy with respect to AKI duration in critically ill patients: results of a multicenter cohort studySophie Perinel Ragey, Anne Sophie Truche, Bertrand Souweine, Sébastien Bailly, Elie Azoulay, Lila Bouadma, Christophe Clec'h, Maïté Garrouste-Orgeas, Antoine Gros, Carole Schwebel, Christophe Adrie, Anne Sylvie Dumenil, Laurent Argaud, Samir Jamali, Dany Goldgran Toledano, Guillaume Marcotte, Michaël Darmon, Jean-François Timsit, For the OUTCOMEREA study groupO68 Early versus delayed initiation of renal replacement therapy in septic acute kidney injury: a retrospective studyMikhael Chouraqui, Antoine Dewitte, Brigitte Chastel, Pauline Carles, Catherine Fleureau, Olivier Joannes-Boyau, Alexandre OuattaraO69 Renal recovery after severe acute kidney injury in critically ill myeloma patientsAdrien Joseph, Marion Venot, Sandrine Valade, Eric Mariotte, Claire Pichereau, Akli Chermak, Virginie Lemiale, Elie Azoulay, Emmanuel CanetO70 Impact of proactive nurse participation in ICU family conferences: a Mixed-Method StudyMaïté Garrouste-Orgeas, Adeline Max, Talia Lerin, Charles Grégoire, Stephane Ruckly, Martin Kloeckner, Cédric Bruel, Sandie Brochon, Francois Philippart, Emmanuelle Pichot, Clara Simons, Jean-François Timsit, Benoit MissetO71 Duration of platelet storage and outcome of critically ill patientsAndrew Flint, Cécile Aubron, Michael Bailey, Rinaldo Bellomo, David Pilcher, Allen Cheng, Colin Hegarty, Anthony Martinelli, Benjamin Howden, Michael Reade, Zoe McquiltenO72 REA-C-SUR safety culture in intensive care in France: is there a link with morbi-mortality conferences?Cédric Bretonnière, Daniel Villers, Christophe Guitton, Groupe RMM, Qualité et Sécurité des Soins - CBPR-CFARO73 Survival of critically ill solid cancer patients: results of a retrospective multicentre studyM Soares, Virginie Lemiale, Djamel Mokart, Frédéric Gonzalez, Fabrice Bruneel, Yves Cohen, Elie Azoulay, Michaël Darmon, François Vincent, for the GrrrOH: Groupe de recherche en réanimation respiratoire en Onco-Hématologie (Group for Research in Respiratory Intensive Care Onco-Hematology)O74 Encouraging results of the French controlled donation after circulatory death Maastricht category III ProgramClémence Fauché, Michel Muller, Samuel Gay, Olivier Skowron, Albrice Levrat, Didier DorezO75 Clinical significance of cardiac troponin I release in severe trauma patientsMaxens Decavèle, Arnaud Foucrier, Sebastian Pease, Tobias Gauss, Catherine PaugamO76 The modified Glasgow prognostic score is helpful in screening lung cancer patient at risk of hospitalization at the emergency departmentJulie Gorham, Lieveke Ameye, Marianne Paesmans, Thierry Berghmans, Jean-Paul Sculier, Anne-Pascale MeertO77 Relationship between body mass index classes and massive transfusion needs in trauma patients and predictive performance of the TASH score in obese and non-obese populations: a retrospective study on 910 trauma patientsAudrey De Jong, Pauline Deras, Orianne Martinez, Pascal Latry, Samir Jaber, Xavier Capdevila, Jonathan CharbitO78 The Eschmann stylet as first tracheal access tool during emergency difficult tracheal intubation: An initial simulation trial followed by a clinical studyJaubert J., Celia Etiennar, Lucie Ginoux, Jean-Luc Sebbah, Hakim Haouache, Gilles DhonneurO79 Maternal mortality risk factors for eclampsiaChaigar Mohammed Cheikh, I. Moussaid, O. Ghazaoui, Kamal Belkadi, S. El Youssoufi, S. SalmiO80 Use of aminoglycosides in cirrhotic patients admitted in intensive care for severe sepsis or septic shock: short- and intermediate-term impact on renal function and mortalityLaure Pajot, Benjamin Zuber, Carole Schwebel, Romain Sonneville, Benoit Misset, Michael Darmon, Guillaume Marcotte, Anne Sophie Truche, Dany Goldgran-Toledano, Bertrand Souweine, Samir Jamali, Stephane Ruckly, Elie Azoulay, Christophe Clec'h, Jean Pierre Bedos, Jean-François Timsit, OutcomeRéaO81 Diagnostic yield and therapeutic impact of liver biopsy in the intensive care unitBertrand Sauneuf, Benoit Dupont, Axelle Eugène, Jean-Luc Hanouz, Françoise Galateau-Sallé, Nicolas TerziO82 Critically ill patients requiring liver transplantation: a 7-year monocentric retrospective experienceBaptiste Michard, Benjamin Lebas, Alexandra Boivin, Max Guillot, Jean-Etienne Herbrecht, Marie-Line Harlay, Ralf Janssen-Langenstein, Maleka Schenck, Bernard Ellero, Marie-Lorraine Woehl-Jaegle, Camille Besch, Vincent Castelain, Philippe Bachellier, Francis SchneiderO83 Hospital survival and access to liver transplantation of MARS-treated patients in France, 2004-2008: a retrospective multicenter study (RETROMARS)Christophe Camus, Fawzi Saliba, Bernard Goubaux, Agnès Bonadona, Laurence Lavayssiere, Catherine Paugam, Alice Quinart, Olivier Barbot, Sebastien Dharancy, Bertrand Delafosse, Nicolas Pichon, Helene Barraud, Arnaud Galbois, Benoit Veber, Sophie Cayot, Bruno Souche, Clara Locher, RETROMARS Study GroupOlivier Roux, Francesco Figorilli, Antonella Putignano, Pauline Houssel, Claire Francoz, Emmanuel Weiss, Catherine Paugam, Banwari Agarwal, Rajiv Jalan, François DurandP1 Severe brain injuries: epidemiology and outcome in a Tunisian medical intensive care unitHassen Ben Ghezala, Salah Snouda, Rebeh Daoudi, Moez KaddourP2 Stroke prognosis in the ICU of the regional hospital of Bizerte and withhold and withdrawal treatment decisionsHatem Ghadhoune, E. Rachedi, J. Guissouma, A. Ben Slimene, W. Azzeza, H. Brahmi, H. ElghordP3 Brain death predictive factors for traumatic brain injuryAhmed Youssef Kada, Radia Chikh, Roza Slimani, Kheireddine.a BouyoucefP4 Guillain-Barré syndrome in intensive care unit: epidemiology and prognostic factors: analysis of 30 patientsKais Regaieg, Chtara Kamilia, Najeh Baccouch, Olfa Turki, Anis Chaari, Hmida Chokri Ben, Mabrouk Bahloul, Mounir BouazizP5 Eclampsia: epidemiological and clinical study about 194 casesFatma Kaaniche Medhioub, Najeh Baccouch, Manel Zekri, Kais Rgieg, Chokri Bhimada, Bouaziz MounirP6 Neuroimagery in eclampsia and preclampsiaChaigar Mohammed Cheikh, I. Moussaid, Kamal Belkadi, O. Ghazaoui, S. El Youssoufi, S. SalmiP7 Interest of brain oxygen tension measurement (PbrO2) in the diagnosis of cerebral vasospasm after aneurismal subarachnoid hemorrhageElodie Lang, Stephane Welschbillig, Fabian Roy-Gash, Nicolas EngrandP8 Noninvasive ventilation: an alternative to the intubation during myasthenic crisisMathilde Perrin, Fabian Roy-Gash, Stephane Welschbillig, Jean-Michel DevysP9 Interest of the transcranial Doppler ultrasound in the management of severe traumatic brain injurySoumia Benbernou, Houria Mokhtari-Djebli, Sofiane Ilies, Khalida Bouyacoub, Abdelkader AzzaP10 VV-ECMO on ARDS: toward a lower anticoagulation ratio?Elie Zogheib, Joseph Nader, Léonie Villeret, Mathieu Guilbart, Patricia Besserve, Thierry Caus, Hervé DupontP11 Inter-hospital transportation of patients implanted with veno-venous ECMO: Experience of the Pitié-Salpêtrière mobile ECMO teamNicolas Brechot, Ciro Mastroianni, Matthieu Schmidt, Francesca Santi, Guillaume Lebreton, Charles-Edouard Luyt, Jean Louis Trouillet, Ania Nieszkowska, Guillaume Hékimian, Leprince Pascal, Jean Chastre, Alain CombesP12 Evolution of tidal volume and compliance under pressure-controlled mode during the first 24 hours of ECMO ARDS patients transported to a referral centerHadrien Roze, Benjamin Repusseau, Jean-Christophe Richard, Virginie Perrier, Alexandre OuattaraP13 Extracorporeal dioxide carbon removal (ECCO2R), a French national surveyBenjamin Deniau, Jean-Damien Ricard, Jonathan Messika, Didier Dreyfuss, Stéphane GaudryP14 Levels of microparticles in acute respiratory distress syndrome with veno-venous extra-corporeal membrane oxygenationChristophe Guervilly, Fanny Klasen, Sami Hraiech, Jean-Marie Forel, Laurent PapazianP15 In patients under extracorporeal CO2 removal therapy (ECCO2R) for ARDS can we do prone position? Efficiency, stability and safety of the maneuverJean Pierre Ponthus, Polysie Ngasseu, Virginie Amilien, Elise Barsam, Pierre Lehericey, Martial Tchir, Jean Francois GeorgerP16 Feasibility of the implementation of a technique of extra-corporeal CO2 removal (ECCO2R) in an intensive care unit which does not use ECMO and its real utilizationVirginie Amilien, Jean Pierre Ponthus, Polysie Ngasseu, Martial Tchir, Elise Barsam, Pierre Lehericey, Jean Francois GeorgerP17 Six-hour daily session of high-frequency oscillatory ventilation in moderate-to-severe ARDS: impact on the end-expiratory lung volume, compliance and oxygenationBérénice Puech, David Vandroux, Arnaud Roussiaux, Dominique Belcour, Cyril Ferdynus, Olivier Martinet, Julien JabotP18 Can we optimize prescription of laboratory tests in surgical intensive care unit (ICU)? Study of appropriateness of careMarion Fresco, Gaëlle Demeilliers-Pfister, Véronique Merle, Valéry Brunel, Benoit Veber, Bertrand DureuilP19 Impact of the implementation of guidelines for laboratory testing in an intensive care unitSébastien Leydier, Isabelle Clerc-Urmes, Jérémie Lemarie, Charles-Henri Maigrat, Marie Conrad, Aurélie Cravoisy-Popovic, Damien Barraud, Lionel Nace, Sébastien Gibot, Nelly Agrinier, Pierre-Edouard BollaertP20 Identifying useless precaution to reduce costs in ICUVincent Peigne, Jean-Louis Daban, Mathieu Boutonnet, Guillaume Dumas, Elisabeth Falzone, Patrick Jault, Bernard LenoirP21 The ICU of the teaching hospital of KinshasaJoseph Nsiala Makunza, Nathalie MejeniP22 Security culture and risk management in intensive care units: risk cartography in a French intensive care unitAmélie Mazaud, Sébastien Béague, Anne-Flore Rousselle, Alain DurocherP23 Acquiring messages of medical articles according to the reading style: the BIBLIOFLASH multicenter studyRomain Sonneville, Benjamin Sztrymf, Emmanuel Canet, for the BIBLIOFLASH study groupP24 ICU portrayal in social media channelsPauline Perez, Alexandra Grinea, Nicolas WeissP25 The burnout syndrome in a Tunisian intensive care unit: what is the truth?Hassen Ben Ghezala, Naoures Bedoui, Salah Snouda, Rebeh Daoudi, Moez KaddourP26 Resistance of endotracheal tubes measured after extubation in ICU patientsAlina Stoian, Loredana Baboi, Florent Gobert, Hodane Yonis, Romain Tapponier, Jean-Christophe Richard, Claude GuérinP27 Length of endotracheal tube, humidification system and airway resistance: an experimental bench studyFrédéric Duprez, Arnaud Bruyneel, Thierry Bonus, Grégory Cuvelier, Sharam Machayeckhi, Sandra Olieuz, Alexandre LegrandP28 Diagnosis contribution and safety of bronchoalveolar lavage in intensive care unitFatma Feki, Amira Jamoussi, Takoua Merhebene, Emna Braham, Asma Ghariani, Faouzi El Mezni, Leila Slim, Jalila Ben Khelil, Mohamed BesbesP29 Impact of fiberoptic bronchoscopy performed under noninvasive ventilation on the outcome of critically ill patients: a cohort study over 11 yearsAntoine Marchalot, Christophe Girault, Gaetan Beduneau, Dorothée Carpentier, Steven Grange, Emmanuel Besnier, Gioia Gastaldi, Julien Abily, Marion Beuzelin, Fabienne TamionP30 New single-use flexible bronchoscope dedicated for the invasive mechanical ventilation: a proof of conceptMai-Anh Nay, Adrien Auvet, Julie Mankikian, Virginie Hervé, Antoine GuillonP31 Incidence of and risk factors for difficult intubation in ICUMarie Soulie, Pierrick Cronier, Elie Kantor, Laura Federici, Marion Gilbert, Ilham Mezhari, Gérald Choukroun, Sophie MarqueP32 Endotracheal self-extubation in the intensive care unit: a two-year observational studyZ. Coppere, Maxens Decavèle, Jean-Pierre Fulgencio, Clarisse Blayau, Tai Pham, Muriel Fartoukh, Michel DjibreP33 Criteria to assess extubation readiness and prediction of successful weaningMatthieu Reffienna, Michel Arnaout, Sébastien Lefort, Anne-Sophie Debue, Fabrice Daviaud, Sarah Cabon, Frédéric Pène, Julien Charpentier, Alain Cariou, Jean-Paul Mira, Jean-Daniel Chiche, Working Group on Mechanical VentilationP34 Domestic accidents during school holidays in childrenNabil Tabet Aoul, Zakaria Addou, Ali Douah, Mohamed Moussati, Kamel Belhabiche, Nabil AouffenP35 Pediatric ARDS: interest of prone positioning and NAVA ventilation during veno-venous ECMOSylvie Soulier, Philippe Mauriat, Nadir Tafer, Alexandre OuattaraP36 Esogastric pressure measurement as a guide for noninvasive ventilation in unexplained hypercapnic respiratory failure in infantsGuillaume Mortamet, Alessandro Amaddeo, Sonia Khirani, Brigitte FaurouxP37 Experience Of Antibacterial Treatment Of Bone And Joint Sepsis Of Young ChildrenGennadiy Khanes, Olga Liutko, Svitlana BidnenkoP38 Comparison of toxic and septic shocks in childrenSolenn Remy, Emilie Doye, Nicolas Voirin, Delphine Maucort-Boulch, Karine Kolev-Descamp, Guillaume Monneret, Etienne JavouheyP39 Pediatric carbon monoxide poisoning in the Ile-de-France Region, Link between HbCO level and clinical presentationImane El Aouane, Aben Essid, Wallid Hammami, Isabelle Haegy, Jacques Bataille, Jean BergouniouxP40 Refractory septic shock in children: an ESPNIC definitionLuc Morin, Samiran Ray, Graeme Maclaren, Etienne Javouhey, Simon Nadel, Martin Kneyber, Mark Peters, Koos Jansen, Daniele De Luca, Clare Wilson, Luregn Schlapbach, Pierre Tissières, The infection, inflammation and sepsis section of the ESPNICP41 Impact of the Leonetti law on end-of-life practices in a French NICU and PICU, from January 2011 to December 2014Anne-Claire Girard, Elodie Savajols, Antoine Burguet, Denis Semama, Stephanie Litzler-RenaultP42 Mortality risk factors for anticoagulant-related bleedingInes Sedghiani, Hana Fredj, Malek Hassouna, Youssef Zied El Hechmi, Mohamed Ali Cherif, Jerbi ZouheirP43 Management of the polytrauma in the emergency department of CHUOranHouria Mokhtari-Djebli, Soumia Benbernou, Ahmed Dernane, Fouad Bouakkaz, Khalida Bouyacoub, Abdelkader AzzaP44 Realization of a feedback system of respiratory parameters during CPRLhoucine Ben Taleb, Elmaati Essoukaki, A Zeddine Mouhsen, Aissam Lyazidi, Jean-Christophe Marie Richard, Ahmed Mouhsen, Mohammed Harmouchi, Mourad RattalP45 Burns from French military operations: a 14-year retrospective observational analysisMatthias Huck, Thomas Leclerc, Nicolas Donat, Audrey Cirodde, Jean-Vivien Schaal, Yannick Masson, Clément HoffmannP46 Drowning in Martinique-characteristics and infectious complicationsDabor Resiere, Laura Cerland, Ruddy Valentino, C Chabartier, Laurent Villain-Coquet, Jean-Louis Ferge, Y Brouste, Bruno Megarbane, Hossein MehdaouiP47 Prevalence, characteristics, and associated factors to physician's conflicts in Emergency Department: A multicentric Moroccan studyJihane Belayachi, Maha Louriz, Naoufal Madani, Fatiha Amlaiky, Tarek Dendane, Khalid Abidi, Aicha Zekraoui, Amine Ali Zeggwagh, Redouane AbouqalP48 Serious peripartum complications needing admission in obstetrical ICU: retrospective study about 127 casesAffra Brahim, Fehmi Ferhi, Hosni Khouadja, Mohamed Amine Bouslama, Khalil Tarmiz, Khaled BenjaziaP49 Epidemiology of suicide in emergency departmentNeila Maaroufi, Abid Zeineb, Dhaouadi MahassenP50 Beneficial cardiovascular effects of O-GlcNAc stimulation in early phase of septic shockJulien Cadiet, Marine Ferron, Valentine Prat, Angelique Erraud, Virginie Aillerie, Mathieu Mevel, Amandine Grabherr, John C. Chatham, Chantal Gauthier, Benjamin Lauzier, Bertrand RozecP51 MiR-21 deficiency increases mortality during experimental septic shockJeremie Joffre, Xavier Loyer, Jean-Rémi Lavillegrand, Lynda Zeboudj, Ludivine Laurans, Bruno Esposito, Alain Tedgui, Ziad Mallat, Hafid Ait-OufellaP52 Isolated heart rate reduction by ivabradine does not improve cardiac and vascular function in experimental septic shockChaojie Wei, Narimane Al Kattani, Huguette Louis, Sophie Orlowski, Bruno Levy, Antoine KimmounP53 Exploration and modulation of the EGF-R during experimental septic shockJean-Rémi Lavillegrand, Lynda Zeboudj, Jeremie Joffre,, Ludivine Laurans,, Bruno Esposito, Alain Tedgui, Pierre-Louis Tharaux, Hafid Ait-OufellaP54 An intravenous omega-3 bolus at reperfusion time improves shock and vascular dysfunction in a myocardial ischemia-reperfusion rat modelMélanie Burban, Grégory Meyer, Anne Olland, Blandine Yver, Florence Toti, Valérie Schini-Kerth, Alexandra Monnier, Alexandra Boivin, Pierrick Leborgne, Ferhat Meziani, Julie Boisramé-HelmsP55 Impact of urantide antagonist of urotensinergic system on myocardial function during a murine model of septic shockEmmanuel Besnier, Thomas Clavier, Mulder Paulus, Hélène Castel, Vincent Richard, Fabienne TamionP56 Association of dexamethasone and antibodies to poly-β(1,6)-n-acetyl-glucosamine in prevention and treatment of neonatal bacterial meningitis: an experimental studyStéphanie Pons, Bruno Mourvillier, David SkurnikP57 Hyperoxemia as a risk factor for ventilator-associated pneumoniaSophie Six, Karim Jaffal, Saad NseirP59 Significance of prior digestive colonisation with extended-spectrum beta-lactamase producing Enterobacteriaceae in patients with ventilator-associated pneumoniaRémi Bruyère, Clara Vigneron, Audrey Large, Julien Bador, Serge Aho, Sebastien Prin, Jean-Pierre Quenot, Pierre-Emmanuel CharlesP60 Lower respiratory tract colonization in mechanically ventilated patients: Incidence, risk factors and impact on prognosisYosr Touil, Soufia Ayed, Habiba Sik Ali, Najla Tilouch, Houda Mateur, I Talik, Rim Gharbi, Mohamed Fekih Hassen, Souheil ElatrousP61 Epidemiology of ventilator-associated pneumonia in the ICU among patients already hospitalized: early- versus late-onset pneumoniaMathilde Grandperrin, Isabelle Patry, Xavier Bertrand, Jean-Christophe Navellou, Gaël Piton, Gilles CapellierP62 Systematic review of inclusion/exclusion criteria, judgment criteria and statistical hypothesis in randomized controlled trials assessing the efficacy of antimicrobials for hospital-acquired and ventilator-associated pneumonia treatmentEmmanuel Weiss, Jean-Ralph Zahar, Christophe Adrie, Wafa Essaied, Martin Wolkewitz, Jean-François TimsitP63 Gram stain identification resulting from blindly inserted telescoping plugged catheter material. Does it contribute to diagnosis and treatment of ventilator-associated pneumonia?Mickaël Soued, Fabrice Cook, David Lobo, Roman Mounier, Aurélie Emirian, Jean Winoc Decousser, Gilles DhonneurP64 Colistin in nosocomial pneumonia in intensive careHanane Ezzouine, Mohamed Toufik Slaoui, Abdellatif BenslamaP65 Bedside tissue perfusion evaluation predicts intradialytic hemodynamic instability in critically ill patientsNaïke Bigé, Claire Pichereau, Jean-Rémi Lavillegrand, Arnaud Galbois, Mikael Alves, Jean-Luc Baudel, Simon Bourcier, Vincent Dubée, Jalel Tahiri, Eric Maury, Bertrand Guidet, Hafid Ait-OufellaP66 Evaluation of electrolytes and acid-base disorders in patients undergoing citrate-based anticoagulation for continuous renal replacement therapy in intensive care unitBenjamin Delmas, Olivier Joannes-Boyau, Antoine Dewitte, Julien Jabot, Dorothée Valance, Nicolas Allou, Jérôme Allyn, Catherine Fleureau,, Alexandre OuattaraP67 Continuous venovenous hemofiltration in critically ill patients with acute kidney injury: a cost study impact of replacement fluids consumptionsElodie Jean-Bart, Floriane Bel., Fabienne Morey, Rémi Bruyère, Nicholas SedillotP68 Acute kidney injury in patients receiving liposomal amphotericin B in an intensive care unit: register of 104 patients from 2008 to 2014Marion Venot, Lucie Biard, Sylvie Chevret, Sandrine Valade, Eric Mariotte, Claire Pichereau, Virginie Lemiale, Elie Azoulay, Emmanuel CanetP69 Regional citrate-based anticoagulation for dummies in continuous venovenous hemofiltration: does it work?Dorothée Valance, Richard Galliot, Romain Zunarelli, David Vandroux, Cyril Ferdynus, Bernard-Alex Gauzere, Olivier Martinet, Julien JabotP70 Incidence of and risk factors for acute kidney injury in early postoperative liver transplantation according to AKIN classificationJean-Charles Cartier, Thomas Jouve, Marie-Noëlle Hilleret, Rebecca Hamidfar-Roy, Claire Ara-Somohano, Clémence Minet, Agnès Bonadona, Carole SchwebelP71 Metabolic acidosis uncompensated by kidney in septic patients: a predictive factor for acute kidney injury?Aline Pourcelet, Jean-Michel Hougardy, Pierre Defrance, Patrick Biston, Michael PiagnerelliP72 Blood volume monitoring is useful to predict intradialytic hypotension during intermittent hemodialysisLouis De Laforcade, Alexandre Boyer, Didier Gruson, Benjamin ClouzeauP73 Risk factors for occurrence of acute kidney injury in diabetic ketoacidosisNajah Hajjam, Ines Sedghiani, Houda Nasri, Hamdi Doghri, Youssef Zied El Hechmi, Mohamed Ali Cherif, Jerbi ZouheirP74 Face-to-face tracheal intubation with the video laryngoscope Airtraq in the sitting patients: a report of 3-year experience in patients after failed conventional tracheal intubation techniqueGilles Dhonneur, Nicolas Mongardon, Eric Levesque, Hakim HaouacheP75 Ultrasound-guided central venous access technique among French intensivistsMarie-Anaïs Bastide, Jack Richecoeur, Eric Frenoy, Christian Lemaire, Bertrand Sauneuf, Fabienne Tamion, Saad Nseir, Damien Du Cheyron, Hervé Dupont, Julien Maizel, BoReal Study GroupP76 Ultrasound-guided venous catheter insertion. What do French intensivists really do?Hafid Ait-Oufella, Eric Maury, Julien Maizel, Frédérique Schortgen, Cécile Aubron, Christophe Clec'h, Christophe Guitton, Kada Klouche, Nicolas Lerolle, Frédéric Pène, Sebastien Preau, Carole Schwebel, Nicolas Terzi, Frédéric Vargas, Vincent CastelainP77 Can we trust new connected devices recording heart rate and oxygen saturation? A concordance assessment in intensive care unitFranck Ehooman, Yacine Tandjaoui-Lambiotte, Claire Montlahuc, Guillaume Van Der Meersch, Johanna Oziel, Jean Bardon, Matthieu Resche-Rigon, Nicolas Postel-Vinay, Yves CohenP78 Hemoglobin monitoring with HemoCue©, spectrophotometry and blood cells analyzer: comparison of agreement, completion time and costsMehdi Lafi, Frédéric Jacobs, Dominique Prat, Matthieu Le Meur, Olfa Hamzaoui, Anne Sylvie Dumenil, Guy Moneger, Nadège Demars, Pierre Trouiller, Benjamin SztrymfP79 Activated partial thromboplastin time and anti-Xa measurements in heparin monitoring among critical care patientsNoémie Tencé, Inès Zaien, Martine Wolf, Pierre Trouiller, Frédéric JacobsP80 Agreement between the Point-Of-Care Siemens RAPIDPoint(®) 500 Blood gas system and central laboratory measurement of hemoglobin, hematocrit, glucose and electrolytes in ICU patientsJérôme Allardet-Servent, Melissa Lebsir, Christian Dubroca, Mireille Portugal, Matthias Castanier, Thomas Signouret, Guillemette Thomas, Rettinavelou Soundaravelou, Anne Lepidi, Philippe Halfon, Jean-Marie SeghboyanP81 Clinical features and prognosis of pesticide poisoningNeila Maaroufi, Dhaouadi Mahassen, Abid ZeinebP82 Variability of neurobehavioral toxicity of naphyrone, a new synthetic cathinone, according to its acute or binge administrationCamille Gamblin, Nadia Benturquia, Olivier Roussel, Lucie Chevillard, Patricia Risede, Jacques Callebert, Bruno MegarbaneP83 Acute acenocoumarin poisoning: an epidemiological and clinical studyA. M'rad, Hana Fredj, Messaouda Khelfa, Youssef Blel, H. Thabet, Nozha Brahmi, M. AmamouP84 Death by deliberate self-poisoning in Sfax, Tunisia: Victims characteristics and toxic substance profileYoussef Nouma, Wiem Ben Amar, Sami Bardaa, Karama Regaieg, Kaouthar Jammeli, Mabrouk Bahloul, Zouheir Hammami, Maatoug SamirP85 Adverse drug reactions (ADRs) collected by medical-staffed ambulances: pilot studyA. Lillo-Le Louët, F. Baud, C. Le Beller, B. Vivien, L. Soufir, P. Carli and H. Le LouëtP86 Prognostic value of plasma concentration of acebutolol in acute poisoningA. M'rad, Youssef Blel, Fatma Essafi, Nasreddine Foudhaili, Abdelaziz Ben Slimen, Nozha Brahmi, M. AmamouP87 Baseline pharmacologic treatment for patients admitted in ICU for AECOPD: trends in use and conformity to the GOLD guidelinesIslem Ouanes, Rami Jabla, Hedia Hammed, Mahdi Marzouk, Nesrine Boujelbene, Fahmi Dachraoui, Asma Hachani, Saousen Ben Abdallah, Hend Ben Lakhal, Chaima Ghribi, Imen Ben Ali, Imen Abdellaoui, Lamia Ouanes-Besbes, Fekri AbrougP88 Blood eosinophils levels and acute exacerbations of COPDIslem Ouanes, Asma Hachani, Lamia Ouanes-Besbes, Saousen Ben Abdallah, Rami Jabla, Hedia Hammed, Mahdi Marzouk, Hend Ben Lakhal, Imen Ben Ali, Imen Abdellaoui, Chaima Ghribi, Fahmi Dachraoui, Fekri AbrougP89 POFE: postoperative outcomes of chronic obstructive pulmonary disease (COPD) frequent exacerbators after pulmonary resection-a pilot studySuela Demiri, Christine Lorut, Van Lang, Daniel Luu, Antoine Rabbat, Aurélie Lefebvre, Marco Alifano, Jean-Francois Reignard, Marc Samama, Daniel Dusser, Nicolas RocheP90 Optimal delivery of salbutamol with a pressurized metered-dose inhaler within a high-flow nasal therapy circuitFrançois Réminiac, Cassandre Landel, Samuel Gensburger, Thomas Bocar, Lydiane Mordier, Marion Philippe, Déborah Le Pennec, Laurent Vecellio, Stephan EhrmannP91 Differences in perceptions between the various healthcare professionals working at the bedside of the risks related to the rehabilitation proceduresLaurent Poiroux, David Thevoz, Julien Simons, Cheryl Hickmann, Jean Roeseler, Anthéa Loiez, Stéphanie Gérard, Nicolas Dousse, Tai Pham, Nicolas Terzi, Lise PiquilloudP92 Early rehabilitation in critically ill patients: a prospective multicenter assessment of real-life practiceLorraine Ducroux, Sylvie L'hotellier, Elodie Baumgarten, Stéphanie Borschneck, Francis Schneider, Vincent CastelainP93 Extracorporeal membrane oxygenation for pheochromocytoma-induced cardiogenic shock: report of nine casesGuillaume Hékimian, Nicolas Brechot, Matthieu Schmidt, Fatima Kharcha, Cécile Ghander, Guillaume Lebreton, Christophe Tresallet, Jean Louis Trouillet, Pascal Leprince, Alain Combes, Charles-Edouard LuytP94 Mortality related to cardiogenic shock in critically ill patients in France, 1997-2012Etienne Puymirat, Jean-Yves Fagon, Philippe Aegerter, Florence Boissier, Jean-Luc Diehl, Caroline Hauw-Berlemont, Bertrand Guidet, Gilles Chatellier, Nicolas Danchin, Nadia AissaouiP95 Benefits of extracorporeal life support (ECLS) in elderly patients with postcardiotomy refractory cardiogenic shockNadia Aissat, R. Bernard, Guillaume Lebreton, Dimitri Margetis, Julien Amour, Pascal Leprince, Adrien BougléP96 Heart transplantation versus ventricular assist device: which therapy for patients with refractory cardiogenic shock?Charles Vidal, Guillaume Lebreton, Djavidi Nima, Varnous Shaida, Adrien Bouglé, Pascal Leprince, Julien AmourP97 Refractory cardiogenic shock in immunocompromised patients rescued by veno-arterial extracorporeal membrane oxygenationAmandine Dorget, Nicolas Bréchot, Guillaume Lebreton, Guillaume Hekimian, Ania Nieszkowska, Charles-Edouard Luyt, Pascal Leprince, Jean Louis Trouillet, Alain Combes, Matthieu SchmidtP98 Which index severity to use in obstetric medium? (Comparison of 4 scores)Rabi Toufiki, Youssef Mouaffak, Ahmed Rhassan El Adib, M. AmineP99 Maternal mortality in obstetric department of UH IBN ROCHD, Casablanca, MoroccoKamal Belkadi, I. Moussaid, Chaigar Mohammed Cheikh, S. Moumine, S. El Youssoufi, S. SalmiP100 Disseminated intravascular coagulation in pregnant women: evaluation of a new scoreMarie Jonard, Anne Sophie Ducloy-Bouthors, François FourrierP101 Validity of severity scores in critically ill obstetric patientsFatma Kaaniche Medhioub, Anis Chaari, Olfa Turki, Kais Rgieg, Mabrouk Bahloul, Hmida Chokri Ben, Bouaziz MounirP102 Evaluation of a neuromuscular blockade with benzylisoquinoliniums: a comparison of a train of four with a clinical assessmentPierre Bouju, Nicolas Barbarot, Arnaud Gacouin, Fabrice Uhel, Julien Letheulle, Pierre Fillatre, Guillaume Grillet, Angélique Goepp, Jean-Marc Tadié, Yves Le TulzoP103 The use of enteral route for drug administration in the ICU is dimly rationalAnne-Laure Clairet, Gilles Capellier, Samuel Limat, Christian Cornette, Gaël PitonP104 Microcirculatory effects of norepinephrine in septic shock: a muscle microdialysis studyAmira Fatnassi, Zied Hajjej, Chiheb Romdhani, Walid Sammoud, Iheb Labbene, Mustapha FerjaniP105 Administration of drugs per os by stomach tube for enteral feeding in surgical ICUHind Taibi, Ijlal Elatiqi, A Iraqui, Rachid Cherkab, Wafae Haddad, Chafik Elkettani, Lahoucine BarrouP106 Implementation of an intensive care follow-up clinicFabien Cave, Alain Mercat, Nicolas LerolleP107 Needs assessment of adults post-intensive care rehabilitation department in Amiens University HospitalGaelle Bacari-Risal, Pierre Louis Doutrellot, Benoit Vaysse, M. Inan, K. Khelfoun, M. Nasserallah, Julien Maizel, C. Legrand-Monteil, S. Tasseel-PoncheP108 Factors of degradation on independence and quality of life at 3 and 6 months after stay in intensive care unitBenjamin Kowalski, Anne Guaguere, Claire Boulle-GeronimiP109 Octavie: Epidemiological study of mortality and autonomy 3 and 6 months after ICU stay for very elderly patientsJuliette Masse, Clément Vanbaelinghem, Patrick HerbecqP110 Analysis of burn injuries in the elderlyAmel Mokline, Syrine Draief, Lazhari Gharsallah, Imen Rahmani, Bahija Gasri, Sofiene Tlaili, Rym Hammouda, Amen Allah MessadiP111 ICU admission criteria for patients 85 years and olderPhilippe Michel, Bruno Gelée, Fouad Fadel, Marie ThuongP112 Facteurs pronostiques chez les patients âgés admis en réanimation médicale. Prognostic factors in elderly patients admitted in medical intensive careSandra Ait-Aoudia, Salima Laddi, Mohamed-Mohcen SahraouiP113 Uncontrolled donation after circulatory determination of death: 42 months of experience in a general hospitalClémence Fauché, Samuel Gay, Michel Muller, Anna Faucher, Olivier Skowron, Albrice Levrat, Didier DorezP114 Epidemiology of long stays in ICUBertrand Hermann, Caroline Hauw Berlemont, Alexandra Monnier, Florence Boissier, Nadia Aissaoui, Jean-Yves Fagon, Jean-Luc Diehl, Emmanuel GuérotP115 Are daily sedation stops safe in a medical ICU?Michel Arnaout, Julien Charpentier, Benoit Champigneulle, Julie Busson, Anne-Sophie Debue, Julie Dhumeaux, Guillaume Geri, Wulfran Bougouin, Nicole Ericher, Sébastien Lefort, Pierre Lucas, Alain Cariou, Jean-Paul Mira, Frédéric Pène, Jean-Daniel Chiche, Groupe de travail sur la ventilationP116 Delay in awakening after stopping continuous sedation in critically ill patients: incidence, risk factors and impact on ventilator weaningMagalie Dumas, Celine Chapelle, Benedicte Philippon-Jouve, Jerome Morel, Pascal BeuretP117 Risk factors and prognosis impact of decreased patient-ventilator synchrony in mechanically ventilated patients-a prospective studyCôme Bureau, Camille Rolland-Debord, Tymothée Poitou, Marc Clavel, Sébastien Perbet, Nicolas Terzi, Achille Kouatchet, Thomas Similowski, Alexandre Demoule, Université Paris 6-Pierre et Marie Curie and Institut National pour la Santé et la Recherche Médicale, UMRS1158, ParisP118 High-flow oxygen therapy through a nasal cannula versus noninvasive ventilation versus in immunocompromised patients with acute respiratory failureRemi Coudroy, Angéline Jamet, Philippe Petua, René Robert, Jean-Pierre Frat, Arnaud, W. ThilleP119 The use of dexmedetomidine in patients with noninvasive ventilation: a preliminary studyHassen Ben Ghezala, Salah Snouda, Rebeh Daoudi, Moez KaddourP120 Comparison of tolerance of 4 interfaces for preventive noninvasive ventilation after abdominal surgery in intensive care units assessed by patients and caregiversAudrey De Jong, Albert Prades, Marion Monnin, Martin Mahul, Marion Basty, Clément Monet, Benjamin Mounet, Emmanuel Futier, Gérald Chanques, Samir JaberP121 Dexmedetomidine, new approach in sedation analgesia: a prospective and observational study of mechanically ventilated patients in adults intensive care units in a university hospital during the first year of useAudrey Leroux, Xavier Oudinot, Gaëlle Demeilliers-Pfister, Marc LaurentP122 Pain, confusion, and agitation associated with noninvasive ventilationNesrine Boujelbene, Rami Jabla, Fahmi Dachraoui, Islem Ouanes, Saousen Ben Abdallah, Mahdi Marzouk, Asma Hachani, Hedia Hammed, Hend Ben Lakhal, Imen Ben Ali, Chaima Ghribi, Imen Abdellaoui, Lamia Ouanes-Besbes, Fekri AbrougP123 Impact of metformin on prognosis of ICU patientsSebastien Jochmans, Jean-Emmanuel Alphonsine, Ly Van Vong, Nathalie Rolin, Oumar Sy, Jean Serbource-Goguel, Jonathan Chelly, Olivier Ellrodt, Mehran Monchi, Christophe VinsonneauP124 Serum cholinesterase activity in the diagnosis of septic shock due to bacterial infections: a new specific biomarker of sepsisMabrouk Bahloul, Turki Olfa, Najeh Baccouche, Kais Regaieg, Chtara Kamilia, Benhamida Chokri, Hedi Chelly, Mounir BouazizP125 Is hyperoxaemia a rare event during septic shock patients management?Amélie Trichot, Gwenhaël Colin, Jean-Baptiste Lascarrou, Isabelle Vinatier, Konstantinos Bachoumas, Jean-Claude Lacherade, Maud Fiancette, Aurélie Joret, Aihem Yehia, Christine Lebert, Matthieu Henry-Laguarrigue, Laurent Martin-LefèvreP126 Myocardial depressant factor during human septic shock: screening of twenty-three cytokines and chemokinesKeyvan Razazi, Florence Boissier, Mathieu Surenaud, Alexandre Bedet, Nicolas de Prost, Aurelien Seemann, Christian Brun-Buisson, Sophie Hüe, Armand Mekontso-DessapP127 Plasma of septic shock patients modifies in vitro mitochondrial respiration of human PBMC as well as lymphocytes and monocytes cell linesRaphaël Clere-Jehl, Julie Boisramé-Helms, Anne-Laure Charles, Pierrick Leborgne, Xavier Delabranche, Bernard Geny, Ferhat Meziani, Pascal BilbaultP128 Assessment of skin endothelial functions during severe infectionsSimon Bourcier, Claire Pichereau, Vincent Dubée, Gabriel Lejour, Jean-Luc Baudel, Arnaud Galbois, Jalel Tahiri, Naïke Bigé, Eric Maury, Bertrand Guidet, Hafid Ait-OufellaP129 Toe-to-Room temperature gradient correlates with tissue perfusion and predicts outcome during septic shockSimon Bourcier, Claire Pichereau, Pierre Yves Boêlle, Nemlaghi Safaa, Vincent Dubée, Gabriel Lejour, Jean-Luc Baudel, Arnaud Galbois, Jean-Rémi Lavillegrand, Naïke Bigé, Jalel Tahiri, Eric Maury, Bertrand Guidet, Hafid Ait-OufellaP130 Determination of HLA-DR expression on monocytes in heart recipients and clinical outcome correlationSylvie Paulus, Claire Flamens, Guillaume Monneret, Julie Demaret, Jean NeideckerP131 Nosocomial infections in neonates under ECMOJerome Rambaud, Cecile Allioux, Romain Guedj, Isabelle Guellec, Julia Guilbert, Pierre-Louis Leger, Maryne Demoulin, Amélie Durandy, Sandrine Jean, Ricardo CarbajalP132 Point-of-care ultrasound in pediatric and neonatal intensive care units: prospective, observational transversal studyAurélie Morand, Laurent Zieleskiewicz, Olivier Brissaud, Stéphane Le Bel, Mickael Afanetti, Zoé Meresse, Astrid Botte, Michel Panuel, Laurent Thomachot, Jean-Michel Constantin, Marc Leone, Fabrice MichelP133 Use of continuous infusion of clonidine for sedation in critically ill children: indications, efficacy and side effectsAnna Deho', Laïly Sadozai, Stéphane Dauger, Sonia Prot-LabartheP134 Pharmacokinetic analysis of continuous infusion vancomycin therapy in critically ill childrenMathieu Genuini, Mehdi Oualha, Moulin Florence, Jean-Marc Treluyer, Fabrice Lesage, Sylvain RenolleauP135 Incidence of central venous catheter-associated bacteraemia in a paediatric intensive care unitEmmanuelle Chalavon, Claire Le Reun, Rodrigue Dessein, Bruno Grandbastien, Alain Duhamel, Sarah Pesin, François Dubos, Stéphane LeteurtreEmmanuelle Chalavon, Claire Le Reun, Rodrigue Dessein, Bruno Grandbastien, Alain Duhamel, Sarah Pesin, François Dubos, Stéphane LeteurtreP136 Outcome at 2 months at the infectious level of the pediatric central venous catheters: prospective evaluation of the guidelines optimization impactMarie-Aude Puel, Marie Szulc, Anais Philippe, François Severac, Dominique Astruc, Pierre Kuhn, Philippe DesprezMarie-Aude Puel, Marie Szulc, Anais Philippe, François Severac, Dominique Astruc, Pierre Kuhn, Philippe DesprezP137 Ten years of intensive care in children hospital in Oran, AlgeriaNabil Tabet Aoul, zakaria addou, Ali Douah, Mohamed Moussati, Kamel Belhabiche, Nabil AouffenNabil Tabet Aoul, zakaria addou, Ali Douah, Mohamed Moussati, Kamel Belhabiche, Nabil AouffenP138 High-frequency percussive ventilation during neonatal transportation: a pilot studyBenoît Colomb, Karine Kolev-Descamp, Anne Marie Petion, Laurent Queudet, Elodie Savajols, Stephanie Litzler-Renault, Denis SemamaP139 Lymphopenia after severe infectious shock in children: association with severity and risk for nosocomial infectionEmilie Doye, Solenn Remy, Nicolas Voirin, Delphine Maucort-Boulch, Karine Kolev-Descamp, Guillaume Monneret, Etienne JavouheyP140 Importance of troponin evaluation in scorpion envenomation in pediatric intensive care unitMouaffak YoussefP141 Hyperosmolar therapy in pediatric traumatic brain injury: a retrospective studyNadia Roumeliotis, Christian Dong, Geraldine Pettersen, Louis Crevier, Guillaume EmeriaudP142 Cerebral sinovenous thrombosis in children: report of seven casesMouaffak YoussefP143 Optimising nurse confidence and skill acquisition in paediatric continuous renal replacement therapy (pCRRT) through a training programme: result of the first-year experience in a tertiary care centreJérôme Naudin, Laetitia Abdallah, Marion Ganier, Karine Frannais, Dylia Douglas, Cecile Flusin, Anna Deho', Stéphane DaugerP144 From high-quality electronic database to the new concept of perpetual patient. Preliminary resultsDavid Brossier, Redha Eltaani, Michaël Sauthier, Guillaume Emeriaud, Bernard Guillois, Philippe JouvetP145 Transportation of children on extracorporeal membrane oxygenation: 1-year experience of a tertiary referral center in the Paris regionJerome Rambaud, Pierre-Louis Leger, Michelle Larroquet, Alain Amblard, Noella Lode, Julia Guilbert, Sandrine Jean, Isabelle Guellec, Isabelle Casadevall, Katia Kessous, Hervé Walti, Ricardo CarbajalP146 Acute neurotoxicity of bath salts combining 3,4-methylenedioxypyrovalerone and mephedrone in the ratChristophe Poiré, Nadia Benturquia, Olivier Roussel, Lucie Chevillard, Patricia Risede, Jacques Callebert, Huixiong Chen, Bruno MegarbaneP147 Acute organophosphate poisoning: what about pralidoxime use?A. M'rad, Sahar Habacha, Bassem Chatbri, Youssef Blel, H Thabet, Nozha Brahmi, M. AmamouP148 Acute nifedipine poisoning: clinical and prognosis aspectsA. M'rad, Fatma Essafi, Nasreddine Foudhaili, Youssef Blel, H. Thabet, Nozha Brahmi, M. AmamouP149 Acute behavioral toxicity and addictive liability of the new synthetic cathinone 3,4-methylenedioxypyrovalerone (MDPV) in the ratCyril Masniere, Nadia Benturquia, Olivier Roussel, Lucie Chevillard, Patricia Risede, Jacques Callebert, Bruno MegarbaneP150 Clinical and therapeutic characteristics of metformin poisoningA. M'rad, Messaouda Khelfa, Hana Fredj, Youssef Blel, H. Thabet, Nozha Brahmi, M. AmamouP151 Calcium channel blockers poisoningSamar Souissi, Hatem El Ghord, N. Kouraichi, N. Brahmi, H. Thabet, M. AmamouP152 Characteristics and outcomes in patients with community-acquired pneumonia admitted to intensive care unitTakoua Marhbène, Islam Mejri, Amira Jamoussi, Douha Lakhdar, Asma Ghariani, Leila Slim, Jalila Ben Khelil, Mohamed BesbesP153 Comparison of characteristics and outcomes of pneumococcal community-acquired pneumonia versus other pathogensTakoua T. Merhabane, Héla Maamouri, Amira Jamoussi, Asma Ghariani, Leila Slim, Jalila Ben Khelil, Mohamed BesbesP154 Outcome of L. pneumophila pneumonia and risk factors for ICU admissionOestreicher Charlotte, Helena Wegelius, Caroline Landelle, Jacques Schrenzel, Laurent Kaiser, Jérôme PuginP155 The descending necrotizing mediastinitis: report of 60 casesHind BelhadjP156 Characteristics, mortality risk factors and therapeutic approach of ARDS in patients with severe leptospirosis in Reunion IslandPaul Chanareille, Julien Jabot, Benjamin Delmas, Arnaud Roussiaux, Cyril Ferdynus, Bernard-Alex Gauzere, Olivier Martinet, David VandrouxP157 Characterization of organ dysfunction in severe leptospirosisAdélie Ladureau, Alice Sanna, Amélie Rolle, Bertrand Pons, Pascale Piednoir, Fanny Ardisson, Frédéric Martino, Thomas Bernos, Khalid Elkoun, Elie Elain, Roland Lawson, Matthieu Resh-Rigon, Sophie Belorgey, Guillaume ThieryP158 Report of experience: management of a pre-XDR and XDR-TB population hospitalized in a medical ICUCaroline Hauw Berlemont, Cyprian Pricopi, Florence Boissier, Alexandra Monnier, Françoise Barthes, Jean-Luc Diehl, Jean-Yves Fagon, Emmanuel GuérotP159 Benefit of magnesium sulfate for tetanus management in adults: case of the provincial general referral hospital of KinshasaThansya Doddie, Mj Nsiala, Nh Situakibanza, Be Amisi, Mj Kazadi, Ma KilembeP160 Ebola fever outbreak: questioning the delivery of careChristophe Clement, François LamontagneP161 Marked decrease in the incidence of ventilator-associated pneumonia using a bundle of care containing selective oropharyngeal decontaminationBoyer, Valérie Nocquet, Caroline Landelle, Sébastien Naimo, Ronan Raulais, Emilie Genevois, Lucie Bouchoud, Filippo Boroli, Nour Abidi, Mohamed Abbas, Stefan Harbarth, Jérôme PuginP162 Ventilator-associated pneumonia prevention by oral care improvement: a before-after studyPierre-Emmanuel Charles, Caroline Dereux, Audrey Large, Rémi Bruyère, Sebastien Prin, Julien Bador, Jean-Pierre QuenotP163 Impact of a multifaceted bundle ventilator-associated pneumonia prevention program in a secondary care medical-surgical intensive care unitStanislas De Guillebon, Eloise Morisse, Julie France, Deborah Gasser, Philippe Badia, Walter PicardP164 Daily chlorhexidine bathing in a medical intensive care unit: effects on healthcare-associated infections and on acquisition of multidrug-resistant bacteriaP. Corne, Nicolas Molinari, I. De Boulastel, S. Seguin, A. Blasco, V. Ledur, Olivier Jonquet, Kada KloucheP165 Impact of twin bedrooms intensive care unit on the epidemiology of extended-spectrum beta-lactamase-producing enterobacteriaceaePaktoris-Papine Sophie, Margaux Artiguenave, Faten El Sayed, Florence Espinasse, Aurélien Dinh, Cyril Charron, Xavier Repessé, Antoine Vieillard-BaronP166 Prophylactic confinement after liver transplant: a necessity or a useless precaution?Benjamin Lebas, Sophie Hatsch, Quentin Maestraggi, Anne-Florence Dureau, Vincent Castelain, Bernard Ellero, François Faitot, Max Guillot, Francis SchneiderP167 Proteomic response and adaptation mechanisms of E. coli 536 to overcome the inhibitory effect of cranberry proanthocyanidinsDimitri Margetis, Odile Bouvet, Didier Chevret, Didier Dreyfuss, Erick Denamur, Jean-Damien RicardP168 Is daily measurement of CRP useful to detect earlier ventilator-associated pneumonia?Justine Simonet, Mathieu Boutonnet, Jean-Louis Daban, Elisabeth Falzone, Guillaume Dumas, Philippe Vest, Vincent PeigneP169 Clinical and biological features of healthcare-associated coagulase-negative Staphylococci meningitis: results of a retrospective studySeverine Couffin, David Lobo, Gilles Dhonneur, Roman MounierP170 Prognostic value of electrocardiographic abnormalities in patients with acute pulmonary embolismM. Cheikh Bouhlel, Ahmed Khedher, Kaoula Meddeb, A. Azouzi, Y. Hamdaoui, Jihene Ayachi, W. Brahim, Rania Bouneb, Mohamed BoussarsarP171 Does mean arterial pressure alarm improve the time spent within blood pressure target range in septic shock? A before and after studyNans Florens, Martin Cour, Julie Varéon, Arnaud Malatray, Romain Hernu, Laurent ArgaudP172 Respiratory change of pulse pressure is not indicative of preload reserve in cardiac surgery patientsPierre Dupland, Thomas D'humières, Romain Vergier, Pauline Issaurat, Philippe Estagnasié, Pierre Squara, Alain BrussetP173 Importance of diastolic arterial pressure to optimize pulse pressure variation performances for patients receiving norepinephrineVincent Génin, David Vandroux, Cyril Ferdynus, Arnaud Roussiaux, Jérôme Allyn, Nicolas Allou, Olivier Martinet, Julien JabotP174 Multi-parameter monitoring for tissue perfusion in septic shock: correlations between macrohemodynamic and metabolic parameters: Preliminary resultsAli Jendoubi, Rifka Jlassi, Bassem Hamrouni, Yahia Marzougui, Jihen Kouka, Salma Ghedira, Mohamed HouissaP175 Correlation between changes in levels of N-terminal pro-brain natriuretic peptide (NT-pro-BNP) and weight before and after dialysisKaouther Dhifaoui, Zied Hajjej, Walid Sammoud, Iheb Labbene, Mustapha FerjaniP176 Impact of colonization with multidrug-resistant bacteria on the outcome of patients with hematological malignancies admitted to the intensive care medicineJohanna Oziel, Carole Schwebel, Elie Azoulay, Michaël Darmon, Bertrand Souweine, Lila Bouadma, Guillaume Marcotte, Christophe Clec'h, Yves Cohen, Outcomerea Study GroupP177 ICU moving followed by a drop of imipenem-resistant Pseudomonas aeruginosa Alexy Tran Dinh, Caroline Neulier, Marlène Amara, Nicaise Nebot, Gilles Troché, Nelly Breton, Benjamin Zuber, Sébastien Cavelot, Béatrice Pangon, Jean Pierre Bedos, Jacques Merrer, David GrimaldiP178 Risk factors of carbapenem resistance acquisition in intensive care unitFrançois Labaste, Jean-Marie Conil, Julia Grossac, Stéphanie Ruiz, Marion Grare, Olivier Fourcade, Vincent Minville, Bernard GeorgesP179 Risk factors for subsequent infection among patients with extended-spectrum beta-lactamase-producing enterobacteriaceae colonization: a retrospective studyGuillaume Van Der Meersch, Johanna Oziel, Yacine Tandjaoui-Lambiotte, Frédéric Gonzalez, Philippe Karoubi, Christophe Huang, Christophe Clec'h, Yves CohenP180 Is rectal colonisation predictive of extended-spectrum β-lactamase-producing enterobacteriaceae presence in respiratory samples performed in the intensive care unit?Helene Carbonne, Matthieu Le Dorze, Rishma Amarsy, Joaquim Mateo, Didier Payen de la GaranderieP181 Antibiotic therapy in intensive care unit patients: appraisal of medical attitude related to therapy appropriateness, severity of infection and outcomeSophie Leloup Von Edelsberg, Christelle Vercheval, Monique Nys, Pierre DamasP182 Epidemiology and associated factors of ICU-acquired infections in critically ill patients: a prospective cohort studyZied Hajjej, Chaker Bouguerra, Noura Naas, Walid Sammoud, Iheb Labbene, Mustapha FerjaniP183 The impact of nosocomial infection acquired in intensive care units on mortality and length of stay until hospital discharge: a retrospective, monocentric, 10-year studyJoris Muller, François Severac, Mickael Schaeffer, Pierre Tran Ba Loc, Stéphanie Deboscker, Maleka Schenck, Marie-Line Harley, Ralf Janssen-Langenstein, Jean-Etienne Herbrecht, Benjamin Lebas, Max Guillot, Vincent Castelain, Francis Schneider, Thierry LavigneP184 Incidence and prognosis of catheter-associated urinary tract infections in intensive care unit: the IPRIUS studyJennifer Brunet, Bertrand Canoville, Cédric Daubin, Amélie Seguin, Nicolas Terzi, Xavier Valette, Pierre Verrier, Damien Du CheyronP185 Automatic tube compensation during mechanical ventilation in ICU patients. Meta-analysis of trials on weaning outcome and physiologic effectsAlina Stoian, Claude GuérinP186 Automated oxygen titration during high-flow oxygen therapy. Evaluation of the feasibility in healthy subjectsFrançois Lellouche, Erwan L'her, Pierre Alexandre Bouchard, Mathieu Delorme, Tamer Elfaramawy, Benoit GosselinP187 Accuracy of ventilators for intermediate care to deliver tidal volume. A bench studyClaude Guérin, Loredana Baboi, Sarah Guegan, Fabien SubtilP188 Efficiency of ventilators for intermediate care to deliver adequate FIO2. A bench studyClaude Guérin, Loredana Baboi, Fabien Subtil, Sarah GueganP189 In vitro comparison of inspiratory-synchronized and continuous nebulization modes during noninvasive ventilation: analysis of inhaled and lost dosesJean-Bernard Michotte, Enrico Staderini, Jonathan Dugernier, Rares Rusu, Jean Roeseler, Giuseppe Liistro, Gregory ReychlerP190 Short-term physiological effects of nasal high flow in patients with respiratory distress. Impact of flow rates on the work of breathingMathieu Delorme, Pierre Alexandre Bouchard, Mathieu Simon, François LelloucheP191 Design and implementation of an active artificial lungElmaati Essoukaki, Lhoucine Ben Taleb, Mohammed Harmouchi, Mourad Rattal, Ahmed Mouhsen, Jean-Christophe Marie Richard, A Zeddine Mouhsen, Aissam LyazidiP192 Assessment of the accuracy of ventilator simulation softwaresFrédéric Duprez, Jean Bernard Michotte, Olivier Contal, Thierry Bonus, Sandra Olieuz, Grégory Cuvelier, Sharam MachayeckhiP193 Outcome and early prognostic factors in neutropenic patients admitted to the intensive care unitBecem Trabelsi, Zied Hajjej, Walid Sammoud, Hedi Garsallah, Mustapha FerjaniP194 Blood loss and transfusion practice in medical surgical intensive care unit: 1-year studyWalid Sammoud, Zied Hajjej, Khaoula Harira, Hedi Garsallah, Mustapha FerjaniP195 Atypical hemolytic and uremic syndrome in critically ill adult patientsElie Azoulay, Akli Chermak, Cédric Rafat, Claire Pichereau, Emmanuel Canet, Virginie Lemiale, Valade Sandrine, Marion Venot, Benoît Schlemmer, Eric MariotteP196 Outcome of critically ill patients after allogeneic hematopoietic stem cell transplantation: comparison of cord blood cells with others cells as hematopoietic stem cells sourceCaroline Le Jeune, Florent Wallet, Pascal Roy, Laurent Argaud, Mauricette MichalletP197 Outcome of patients with organ failures related to solid malignancies and receiving chemotherapy in the intensive care unitYoann Zerbib, Julien Maizel, Naïke Bigé, Benoit Misset, Nicolas de Prost, Virginie Lemiale, Sylvie Ricome, François Baudin, Muriel Fartoukh, Frédéric Jacobs, François Blot, Matthieu Schmidt, Antoine Rabbat, Julien Mayaux, Frédéric Gonzalez, Caroline Bornstain, Elie Azoulay, Frédéric PèneP198 Characteristics and outcomes of patients with hematological malignancies (HMs) admitted to the intensive care unitStéphanie Gelinotte, Dorothée Carpentier, Steven Grange, Julien Abily, Marion Beuzelin, Emmanuel Besnier, Gioia Gastaldi, Gaetan Beduneau, Jean-Philippe Rigaud, Christophe Girault, Fabienne TamionP199 Influence of neutropenia on mortality of critically ill cancer patients: Results of a systematic review and meta-analysis of available evidencesMarie Bouteloup, Sophie Perinel Ragey, Elie Azoulay, Djamel Mokart, Michaël Darmon, Groupe de Recherche en Réanimation Respiratoire et Onco-Hematologique (GRRROH)P200 Thrombotic Microangiopathy (TMA) Syndromes in the ICU: experience of a Tunisian ICUJihene Ayachi, Ahmed Khedher, Kaoula Meddeb, A. Azouzi, Y Hamdaoui, H. Nouira, Rania Bouneb, Mohamed BoussarsarP201 "Immunonutrition" failed to improve septic shock-induced vascular dysfunction in a rat modelJulie Boisramé-Helms, Grégory Meyer, Su Degirmenci, Mélanie Burban, Valérie Schini-Kerth, Alexandra Boivin, Raphaël Clere-Jehl, Alexandra Monnier, Christine Kummerlen, Ferhat MezianiP202 PTP1B gene deletion improves glucose metabolism and limits cardiovascular dysfunction in experimental septic shockEugénie Delile, Pierre-Alain Thiébaut, Jean-Claude Do Rego, David Coquerel, Rémi Nevière, Vincent Richard, Fabienne TamionP203 Ascitic fluid TREM-1 for the diagnosis of spontaneous bacterial peritonitisLaure Ichou, Nicolas Carbonell, Pierre-Emmanuel Rautou, Ludivine Laurans, Simon Bourcier, Claire Pichereau, Jean-Luc Baudel, Jean-Baptiste Nousbaum, Christophe Renou, Rodolphe Anty, Jacques Tankovic, Eric Maury, Bertrand Guidet, Luce Landraud, Hafid Ait-OufellaP204 Modulation of inflammatory response related to severe peritonitis by polymyxin-B hemoperfusionRemi Coudroy, Jean-Claude Lecron, Didier Payen de la Garanderie, René Robert, ABDOMIX GroupP205 Descriptive study of ultrasonographic data inside a surgical intensive care unit for cholestasis diagnosis: dechorea studyMichael Helary, Jonathan Paillot, Sebastien Pili-FlouryP206 In-hospital mortality and predictive risk factors for patients with cirrhosisSana Khedher, Amira Maoui, Asma Ezzamouri, Mohamed SalemP207 CONSTIPREA: evaluation of the management of constipation in intensive care-National Survey of French intensivitsLamia Kerdjana, Mihaela Dumitrescu, Olivier Mimoz, Bertrand Debaene, Virginie Migeot, Claire Dahyot-FizelierP208 Corrosive ingestion in adults: endoscopic findings and agents involvedSana Khedher, Asma Ezzamouri, Amira Maoui, Mohamed Salem, Amira A. MaouiP209 Hypoxic hepatitis after out-of-hospital cardiac arrest: incidence, determinants and prognosisBenoit Champigneulle, Guillaume Geri, Wulfran Bougouin, Florence Dumas, Michel Arnaout, Lara Zafrani, Frédéric Pène, Julien Charpentier, Jean-Paul Mira, Alain CariouP210 Aspiration pneumonitis in comatose patients treated with invasive mechanical ventilation. The SPIRE prospective surveyJean-Baptiste Lascarrou, Floriane Lissonde, Aurélie Le Thuaut, Konstantinos Bachoumas, Gwenhaël Colin, Matthieu Henry-Laguarrigue, Maud Fiancette, Jean-Claude Lacherade, Christine Lebert, Isabelle Vinatier, Aihem Yehia, Aurélie Joret, Laurent Martin-Lefèvre, Jean ReignierP211 Ventilator-associated pneumonia (VAP) in cancer patients: impact of 1-year survivalLaura Platon, Jerôme Lambert, David Lagier, Jeanpaul Brun, Antoine Sannini, Laurent Chow-Chine, Magali Bisbal, Marion Faucher, Djamel MokartP212 High-resolution computed tomography (HRCT) patterns in patients with pneumocystis pneumoniaLeïla Mourtada, Lemiale Virgnie, Claire Givel, Valade Sandrine, Claire Pichereau, Emmanuel Canet, Eric Mariotte, Elie AzoulayP213 Plasma endocan predicts the occurrence of acute respiratory distress syndrome (ARDS) in severe sepsis and septic shock patientsAlexandre Gaudet, Erika Parmentier-Decrucq, Nathalie De Freitas Caires, Sylvain Dubucquoi, Philippe Lassalle, Daniel MathieuP214 Comparison of 3 diagnostic methods to identify fluid responsiveness during prone position in ARDSJean-Christophe Richard, Hodane Yonis, Florent Gobert, Romain Tapponnier, Claude GuérinP215 Low pressure support-high PEEP for early severe acute respiratory distress syndrome: a retrospective analysisLuc Quintin, C. Pichot, F. PetitjeansP216 Neutrophil proteases alter the interleukin-22-receptor-dependent lung antimicrobial defenceAntoine Guillon, Youenn Jouan, Daborah Breah, Fabien Gueugnon, Emilie Dalloneau, Thomas Baranek, Clemence Henry, Eric Morello, Jc Renauld, M Pichavant, Philippe Gosset, Y Courty, Patrice Diot, Mustapha Si-TaharP217 Impaired phagocytosis of apoptotic neutrophils in human ARDS: beneficial effects of metforminFabrice Uhel, Murielle Gregoire, Arnaud Gacouin, Yves Le Tulzo, Karin Tarte, Jean-Marc TadiéP218 What are the deteP219 Emergency thoracotomy: development and results in a military trauma centerrminants of needle aspiration success in primary spontaneous pneumothorax?Constance Vuillard, Jean-Damien Ricard, Béatrice La Combe, Stéphane Gaudry, Didier Dreyfuss, Jonathan MessikaP219 Emergency thoracotomy: development and results in a military trauma centerPauline Ponsin, Jean-Louis Daban, Guillaume Boddaert, Bertrand Grand, Vincent Peigne, Yohan Baudoin, Mathieu Boutonnet, Patrick Jault, Stéphane BonnetP220 Management of isthmic aortic rupture in polytraumatized patients in ICU: a report of 12 casesChtara Kamilia, Kais Regaieg, Olfa Turki, Najeh Baccouch, Anis Chaari, Hmida Chokri Ben, Mabrouk Bahloul, Mounir BouazizP221 NT-proBNP levels and echocardiography findings in the etiologic diagnosis of acute dyspneaSalah Snouda, Hassen Ben Ghezala, Mohamed Fehmi Abbes, Rebeh Daoudi, Moez Kaddour, Imen BenchiekhP222 Cardiac decompensation in peripartumKamal Belkadi, I. Moussaid, Chaigar Mohammed Cheikh, S. El Youssoufi, S. SalmiP223 Peripheral intravenous catheter-related complications in an emergency wardInes Sedghiani, Hana Fredj, Hamdi Doghri, Youssef Zied El Hechmi, Mohamed Ali Cherif, Jerbi ZouheirP224 Burnout in the emergency roomNeila Maaroufi, Abid ZeinebP225 Prevalence, and characteristics of elderly patient admitted in a Moroccan Medical Unit for the Acute CareJihane Belayachi, Leila Debono, Naoufal Madani, Fatiha Amlaiky, Tarek Dendane, Khalid Abidi, Aicha Zekraoui, Amine Ali Zeggwagh, Redouane AbouqalP226 Metabolic phenotyping in bronchoalveolar lavage fluids distinguishes influenza and pneumococcal pneumoniaAdrien Auvet, Antoine Guillon, Lydie Nadal-Desbarats, Thomas Baranek, Eric Morello, François Réminiac, Mustapha Si-TaharP227 Microbiological documentation of pneumonia in the ICU by per-bronchoscopic bronchial aspiration (PBA) is very similar to that obtained by bronchoalveolar lavage (BAL)Jean-Luc Baudel, Jacques Tankovic, Redouane Dahoumane, Arnaud Galbois, Hafid Ait Oufella, Georges Offenstadt, Eric Maury, Bertrand GuidetP228 Compliance with the H3 bundle of the 2012 surviving sepsis campaign according to the chain of care of septic patients: the sepsis CHOC studyAmel Filali, Emmanuel Faure, Nicolas Van Grunderbeeck, Olivier Nigeon, Juliette Masse, H Bazus, Jihad Mallat, Didier TheveninP229 CRP ratio as a predictive tool for mortality in ICU septic patientsSophie Lempereur-Legros, Didier Ledoux, Monique Nys, Pierre DamasP230 Candidemia in ICU: Epidemiology and prognostic factorsZied Hajjej, Walid Sammoud, Becem Trabelsi, Iheb Labbene, Mustapha FerjaniP231 Extracorporeal membrane oxygenation cannula-associated infections: implication of virulent Escherichia coli phylogroupsJonathan Messika, Olivier Clermont, Matthieu Schmidt, Alexandra Aubry, Romain Fernandes, Erick Denamur, Alain Combes, Jean-Damien RicardP232 Is diabetes mellitus a risk factor for intensive care unit-acquired infections in intensive care unit patients with hematologic malignancies?Marion Venot, Sylvie Chevret, Djamel Mokart, Frédéric Pène, Virginie Lemiale, Achille Kouatchet, Julien Mayaux, François Vincent, Martine Nyunga, Fabrice Bruneel, Elie AzoulayP233 Should we need aerobic-anaerobic or specific blood culture bottles for diagnosing candidemia in ICU patients?Sébastien Bailly, Jean-François Timsit, Cécile Garnaud, Muriel Cornet, Patricia Pavese, Rebecca Hamidfar-Roy, Luc Foroni, Sandrine Boisset, Carole Schwebel, Danièle MaubonP234 Invasive Candida infection in a Tunisian ICU: an observational cohort studyIslem Ouanes, Maha Abid, Hend Ben Lakhal, Saousen Ben Abdallah, Fahmi Dachraoui, Hedia Hammed, Rami Jabla, Asma Hachani, Mahdi Marzouk, Imen Abdellaoui, Chaima Ghribi, Imen Ben Ali, Lamia Ouanes-Besbes, Fekri AbrougP235 Causes of admission in medical intensive care of patients suffering from severe psychiatric disordersHanane Ezzouine, Constant Aniolo Edith, Abdellatif BenslamaP236 Unplanned extubation in critical care: still to learn from local surveyFrédéric Jacobs, Dominique Prat, Matthieu Le Meur, Olfa Hamzaoui, Anne Sylvie Dumenil, Guy Moneger, Nadège Demars, Pierre Trouiller, Benjamin SztrymfP237 Mortality associated with nights and weekends admission to intensive care unit (ICU): results of a 9-year cohort study (2006-2014)Vincent Brunot, Jean-Emmanuel Serre, P. Corne, Nicolas Molinari, L. Landreau, Olivier Jonquet, Kada KloucheP238 Determinants and outcomes associated with decisions to deny admission in a Tunisian ICURania Bouneb, Kaoula Meddeb, Y. Hamdaoui, H Nouira, A. Azouzi, Jihene Ayachi, Ahmed Khedher, Mohamed BoussarsarP239 Characteristics and outcomes of patients not admitted to ICUNesrine Boujelbene, Rami Jabla, Fahmi Dachraoui, Islem Ouanes, Mahdi Marzouk, Hedia Hammed, Asma Hachani, Hend Ben Lakhal, Chaima Ghribi, Imen Abdellaoui, Imen Ben Ali, Saousen Ben Abdallah, Lamia Ouanes-Besbes, Fekri AbrougP240 Long-term outcomes of critically ill patients with severe acute kidney injury requiring renal replacement therapyVanessa Jean-Michel, Francis Couturaud, Elizabeth Moore, Pierre-Yves Egreteau, Jean-Michel Boles, Cécile AubronP241 Nowadays, SAPSII better predicts 1-year mortality than hospital mortalityJean-Etienne Herbrecht, Max Guillot, Quentin Maestraggi, Charlotte Kaeuffer, Ralf Janssen-Langenstein, Sylvie L'hotellier, Sophie Hatsch, Benjamin Lebas, Alexandra Boivin, Maleka Schenck, Marie-Line Harlay, Anne Meyer, Vincent Castelain, Francis SchneiderP242 Impact of diabetes on burn injury: preliminary results from retrospective studyAmel Mokline, Imen Rahmani, Khaouther Ben Arfi, Lazhari Gharsallah, Sofiene Tlaili, Bahija Gasri, Rym Hammouda, Amen Allah MessadiP243 Withdrawal or withholding of life-sustaining treatments decisions: Is there a risk of excessive influence of medical imaging?Fabrice Lesage, Sylvie Séguret, Laurent Dupic, Laure De Saint Blanquat, Sylvain RenolleauP244 Withholding and withdrawal of life-sustaining treatments in intensive care unit patients: predisposing factors and implementationAnne-Sophie Baptiste, Hugues Georges, Pierre-Yves Delannoy, Patrick Devos, Olivier LeroyP245 Advanced directives in an old patient with suicide attempt: analysis of ICU physicians perceptionDolores Albarracin, A. Ducousso-Lacaze, Angéline Jamet,, Julien Dufour, Séverin Cabasson, Anne Veinstein, Delphine Chatellier, Jean-Pierre Frat, René RobertP246 Having the talk about advance directives in the daily practice: Is a stay in an intensive care unit a good opportunity?Vivien Hong Tuan Ha, Nicolas Lau, Lucie Mimoun, Xavier ForcevilleP247 Long-term outcome of patients who have withheld life support in intensive careAdel Maamar, Stéphanie Chevalier, Vlad Botoc, Yves Le TulzoP248 Epidemiology of refusals in a polyvalent intensive care unit ad outcome of refused patientsStephane Rouleau, David Schnell, Arnaud Desachy, Sylvie Calvat, Philippe Petua, Charles Lafon, Christophe CraccoP249 Ten critical sentences you have already heard in the Intensive Care Unit and the Emergency Department, their real meanings and consequencesNicolas Van Grunderbeeck, J. Temime, Perrine Molmy, Stephanie Barrailler, G. Gasan, Olivier Nigeon, Didier TheveninP250 Communication with the parents: a challenge in the pediatric intensive care unitAgathe Béranger, Charlotte Pierron, Laure De Saint Blanquat, Sandrine Jean, Hélène ChappuyP251 End of life in the intensive care unit: between practice and knowledgePierre-Marie Bertrand, Alexandra Beurton, Laetitia Bodet-Contentin, Julie Boisramé-Helms, Pierre-éRic Danin, Elsa Dubois, Elodie Gélisse, Yasemin Karaca, Pierre Mora, Nicolas de Prost, Damien Roux, Alexis Soummer, Dominique Vodovar, Committee of young intensivists of the French Society for Intensive Care Medicine (FICS)S1 The HICU Score (Hematologic Intensive Care Unit Score): a new prognostic score for predicting 30-day and 1-year mortality of patients with hematologic malignancies admitted in ICUYohan Desbrosses, Guylaine Labro, Gaël Piton, Adrien Chauchet, Etienne Daguindau, François Blot, Eric Deconinck, Gilles CapellierS2 Patients with multiple myeloma in the ICU: trends of use and outcomes over timeAkli Chermak, Adrien Joseph, Virginie Lemiale, Claire Pichereau, Marinne Baron, Emmanuel Canet, Eric Mariotte, Michaël Darmon, Elie AzoulayS3 Impact of bone marrow aspiration on the management of adult critically ill patientsLaure Calvet, Anne Françoise Sapin, Bruno Pereira, Alexandre Lautrette, Bertrand SouweineS4 Red blood cells transfusion in ICU: descriptive analysis of French cohort from "Age BLood Evaluation" clinical trialLucie Vettoretti, Sebastien Pili-Floury, Gaël Piton, Jacques Lacroix, Lucy Clayton, Elham Sabri, Laurent Bardiaux, Pierre Tiberghien, Paul Hebert, Gilles Capellier, ABLE French InvestigatorsS5 Graft-versus-host disease trajectories and mortality in critically ill allogeneic stem cell recipientsClaire Pichereau, Etienne Lengliné, Anne-Sophie Moreau, Eric Mariotte, Marion Venot, Sandrine Valade, Akli Chermak, Virginie Lemiale, Emmanuel Canet, Gérard Socié, Benoît Schlemmer, Elie AzoulayS6 Outcome of 544 patients with solid cancer in the intensive care unit: the Oncoréa studyEdith Borcoman, Virginie Lemiale, Eric Mariotte, Claire Pichereau, Emmanuel Canet, Adrien Joseph, Akli Chermak, Sandrine Valade, Marion Venot, Benoît Schlemmer, Elie AzoulayS7 Assessing the process of ICU admission refusal in critically ill patients with hematological malignanciesKaterina Rusinova, Virginie Lemiale, Matthieu Resche-Rigon, Djamel Mokart, Antoine Rabbat, Frédéric Pène, Achille Kouatchet, Fabrice Bruneel, Julien Mayaux, François Vincent, Pierre Perez, Martine Nyunga, Elie Azoulay, Groupe de Recherche en Réanimation Respiratoire en Onco-HématologieS8 Neurologic and hepatic failures at ICU admission are associated with worst prognosis for patients with lymphomasAurélien Sutra Del Galy, Achille Kouatchet, Mélanie Mercier, Jean-François Hamel, Tommy Raveau, Marie-Pierre Moles, Aline Clavert, Mathilde Hunault-Berger, Alain Mercat, Norbert Ifrah, Aline Schmidt-TanguyS9 Impact of earplugs and eye mask on sleep in critically ill patients: a prospective randomized polysomnographic studyAlexandre Demoule, Serge Carreira, Sophie Lavault, Olivier Pallanca, Elise Morawiec, Julien Mayaux, Isabelle Arnulf, Thomas SimilowskiS10 Diaphragmatic paralysis after adult cardiac surgery: incidence and predicting factorsThomas D'humières, Pierre Dupland, Pauline Issaurat, Romain Vergier, Philippe Estagnasié, Alain Brusset, Pierre SquaraS11 Ultrasound evaluation of diaphragmatic dysfunction: prognostic marker of ICU weaning failureCédric Carrié, Chloé Gisbert-Mora, Eline Bonnardel, Matthieu Biais, Frédéric Vargas, Gilles HilbertS12 A prospective multicentric study to evaluate the impact of breathing variability on clinical outcomes in mechanically ventilated patientsCôme Bureau, Camille Rolland-Debord, Tymothée Poitou, Marc Clavel, Sébastien Perbet, Nicolas Terzi, Achille Kouatchet, Thomas Similowski, Alexandre Demoule, Université Paris 6 -Pierre et Marie Curie and Institut National pour la Santé et la Recherche Médicale, UMRS1158, ParisS13 Nurse-driven sedation protocol with sedation vacation and incidence of unplanned extubationsPierre Lucas, Julien Charpentier, Michel Arnaout, Thomas Joannon,, Sébastien Lefort, Aude Marincamp, Anne-Sophie Debue, Matthieu Reffienna, Frédéric Pène, Jean-Paul Mira, Alain Cariou, Jean-Daniel Chiche, Working Group on Mechanical VentilationS14 Lung ultrasound enables to detect weaning-induced cardiogenic pulmonary oedemaAlexis Ferre, Max Guillot, Jean-Louis Teboul, Daniel Lichtenstein, Gilbert Meziere, Christian Richard, Xavier MonnetS15 Pleural effusion during the weaning from mechanical ventilation: prevalence and impactDamien Roux, Tai Pham, Alexandra Beurton, Muriel Fartoukh, Jean-Damien Ricard, Alexandre Demoule, Martin DresS16 Prognostic impact of left ventricular diastolic dysfunction in patients with septic shockCéline Gonzalez, François Dalmay, Emmanuelle Begot, Nicolas Pichon, Bruno François, Anne-Laure Fedou, Catherine Chapellas, Antoine Galy, Philippe VignonS17 Norepinephrine exerts an inotropic effect at the early phase of human septic shockOlfa Hamzaoui, Mathieu Jozwiak, Thomas Geffriaud, Benjamin Sztrymf, Dominique Prat, Frédéric Jacobs, Xavier Monnet, Pierre Trouiller, Christian Richard, Jean-Louis TeboulS18 Effect of high PEEP after recruitment maneuver on right ventricular function in ARDS: Is it good for the lung and for the heart?Shari El-Dash, Loay Kontar, François Leleu, Bertand De Cagny, François Brazier, Dimitri Titeca, Gaelle Bacari-Risal, Julien Maizel, Michel SlamaS19 Myocardial dysfunction during septic shock: prevalence, prognosis and role of loading conditionsFlorence Boissier, Keyvan Razazi, Aurelien Seemann, Arnaud, W Thille, Nicolas de Prost, Elise Cuquemelle,, Filippo Boroli,, Alexandre Bedet, Pascal Lim, Christian Brun-Buisson, Armand Mekontso DessapS20 Echocardiography for the critically ill: 1-year experience of a noninvasive intensive care unitW Brahim, R Amara, A Azouzi, Ahmed Khedher, Jihene Ayachi, Rania Bouneb, Y Hamdaoui, Kaoula Meddeb, Mohamed BoussarsarS21 Echocardiographic indices to predict fluid responsiveness in ventilated patients with circulatory failure: which threshold for which aim?Emmanuelle Begot, Xavier Repessé, Julie Léger, Gwenael Prat, Cyril Charron, Pierre-Yves Egreteau, Christophe Jacob, Koceila Bouferache, Loay Kontar, Julien Maizel, Michel Slama, Antoine Vieillard-Baron, Philippe VignonS22 Effects of norepinephrine on the right ventricle assessed by transthoracic echocardiography in the ICUClaire Ragot, Laure Corradi, Frédéric VargasS23 Effect of recruitment maneuver on left ventricular systolic strainPablo Mercado, Julien Maizel, Loay Kontar, Bertand De Cagny, François Brazier, Dimitri Titeca, Gaelle Bacari-Risal, Antoine Riviere, Shari El-Dash, Michel SlamaS24 Management of diabetic ketoacidosis in two pediatric intensive care units: comparison of two care protocolsLaure Maurice, Stéphane Dauger, S Julliand, Anna Deho, Fleur Le BourgeoisS25 NUTRI-REAPED: Nutritional status on admission to the pediatric intensive care unit-a French multicentric studyAurelien Jacquot, Frederic Valla, Bénédicte Gaillard-Le Roux, Flavie Letois, Gilles Cambonie, NutriSIPS26 Apnea test in children for brain death diagnosis: efficacy and complicationsAlexandre Salvadori, Gaia Ottonello, Stéphane Blanot, Juliette Montmayeur, Gilles OrliaguetS27 Interest of the ultrasound in the central venous catheterization in children poses in intensive care unitFehmi Ferhi, Hosni Khouadja, Mohamed Amine Bouslama, Affra Brahim, Khalil Tarmiz, Khaled BenjaziaS28 Supraclavicular approach to the innominate vein in pediatric intensive care unit: interest in the prevention of thrombosis and catheter-related blood stream infectionFlora Habas, Julien Baleine, Julia Lebouhellec, Christophe Milesi, Clementine Combes, Gilles CambonieS29 EPURE Study: Preliminary results on the organization of pediatric acute dialysis in 2 French-speaking countriesMaryline Chomton, Philippe Jouvet, Bruno Ranchin, Marie Alice Macher, Théophile Gaillot, EPURE Study GroupS30 Hyperglycemia in severe scorpion envenomed children: incidence and impact outcomeMabrouk Bahloul, Najeh Baccouche, Kais Regaieg, Turki Olfa, Chtara Kamilia, Benhamida Chokri, Hedi Chelly, Mounir BouazizS31 Prehospital care and initial hospital care of pediatric patients with severe trauma hospitalized in the ICU at Grenoble University Hospital, data from the "TRENAU" trauma-systemMurielle Moine, François Xavier Ageron, Claire Jannel, Thierry Debillon, Isabelle WroblewskiS32 Ventilator-associated pneumonia due to multi- or extensively drug-resistant Pseudomonas aeruginosa: comparison with susceptible strainsMatthieu Duprey, Nicolas Bréchot, Alexandra Aubry, Guillaume Hekimian, Matthieu Schmidt, Ania Nieszkowska, Jean Louis Trouillet, Vincent Jarlier, Alain Combes, Jean Chastre, Charles-Edouard LuytS33 Can we predict a secondary documented infection in patients empirically treated for an invasive candidiasis?Sébastien Bailly, Olivier Leroy, Jean-Paul Mira, Hervé Dupont, Jean-Pierre Gangneux, Philippe Montravers, Jean-Michel Constantin, Didier Guillemot, Olivier Lortholary, Pierre-François Perrigault, Elie Azoulay, Jean-François TimsitS34 Should aminoglycosides be administered to hematological patients with septic shock? Data from the Groupe de Recherche respiratoire en Réanimation Onco-Hématologique (Grrr-OH)Thomas Longval, Sylvie Chevret, Fabrice Bruneel, Djamel Mokart, Frédéric Pène, Julien Mayaux, Achille Kouatchet, Martine Nyunga, Antoine Rabbat, Pierre Perez, Christine Lebert, Dominique Benoit, François Vincent, Virginie Lemiale, Elie AzoulayS35 Is de-escalation of antimicrobial therapy safe in hematology patients?David Schnell, Claire Montlahuc, Matthieu Resche-Rigon, Achille Kouatchet, Jean-Ralph Zahar, Michaël Darmon, Frédéric Pène, Virginie Lemiale, Antoine Rabbat, François Vincent, Fabrice Bruneel, Djamel Mokart, Elie AzoulayS36 Pharmacokinetics and absolute bioavailability of voriconazole administered through a nasogastric tube with continuous enteral feeding to critically ill ventilated patientsPhilippe Karoubi, Christophe Huang, Antoine Rabbat, Johanna Oziel, Guillaume Van Der Meersch, Yacine Tandjaoui-Lambiotte, Frédéric Gonzalez, Christophe Clec'h, Christophe Padoin, Yves CohenS37 Which optimal daily dose for linezolid in burn patients?Amel Mokline, Lazhari Gharsallah, Imen Rahmani, Emna Gaies, Sofiene Tlaili, Bahija Gasri, Rym Hammouda, Sameh Triki, Anis Klouz, Amen Allah MessadiS38 Predictive factors of sub-therapeutic peak concentration after a single dose of amikacin in postoperative cardiovascular critically ill patientsMouhamed Moussa, Flavie DesrumauxS39 Supra-therapeutic serum levels and toxicity of beta-lactam antibiotics in septic ICU patients requiring replacement therapy for acute renal failure: a single-center cohort studyFaten May, Marion Perrin, Najoua El-Helali, Jean-Claude Nguyen, Kelly Tiercelet, Stephane Ruckly, Julien Fournier, Mélanie Cherin, Cédric Bruel, Francois Philippart, Maïté Garrouste-Orgeas, Marie Dominique Kitzis, Alban Le Monnier, Jean-François Timsit, Benoit MissetS40 Post-cardiac arrest syndrome: lessons from a monocentric retrospective studyCyrille Mathien, Antoine Poidevin, Luis Donatti, Joy Mootien, Luis Pinto, Mathieu Egard, Gokhan Bodur, Guillaume Barberet, Carmen Ionescu, Frederique Ganster, Philippe Guiot, Khaldoun KuteifanS41 Out-of-hospital cardiac arrest (OHCA) score for prediction of outcome of in-hospital cardiac arrest: results of the OSPICA pilot studyAlain Mpela, Jonathan Chelly, Jennifer Brunet, Stéphane Legriel, Laurent Guérin, Romain Persichini, Alexis Soummer, Bertrand Sauneuf, Tai Pham, Thomas Hullin, Nicolas Deye, Pierre Aubertein, Mehran MonchiS42 Delayed awakening after cardiac arrest: causes and outcome in the Parisian registryMarine Paul, Wulfran Bougouin, Guillaume Geri, Florence Dumas, Benoit Champigneulle, Stéphane Legriel, Julien Charpentier, Jean-Paul Mira, Claudio Sandroni, Alain CariouS43 Incidence and characteristics of sudden unexplained cardiac death: insights from the Parisian registryOlivier Passouant, Guillaume Geri, Florence Dumas, Wulfran Bougouin, Benoit Champigneulle, Michel Arnaout, Jonathan Chelly, Jean-Daniel Chiche, Olivier Varenne, Jean-Paul Mira, Alain CariouS44 Supranormal oxygen tension is not associated with an impaired redox balance in patients resuscitated from cardiac arrestJean-François Llitjos, Camille Chenevier-Gobeaux, Julien Charpentier, Florence Dumas, Guillaume Geri, Wulfran Bougouin, Benoit Champigneulle, Michel Arnaout, Jean-Paul Mira, Frédéric Pène, Frederic Batteux, Alain CariouS45 Impaired biological response to aspirin in comatose patients resuscitated from out-of-hospital cardiac arrestJean-François Llitjos, Ludovic Drouet, Sebastian Voicu, Nicolas Deye, Bruno Megarbane, Patrick Henry, Jean-Guillaume DillingerS46 Gender differences in coronary reperfusion after cardiac arrestWulfran Bougouin, Florence Dumas, Eloi Marijon, Guillaume Geri, Benoit Champigneulle, Jean-Daniel Chiche, Olivier Varenne, Christian Spaulding, Jean-Paul Mira, Xavier Jouven, Alain CariouS47 Prognostic factors of out-of-hospital cardiac arrests in Martinique: prospective study over a period of 29 months, about 385 casesDabor Resiere, A. L. Dessoy, Ruddy Valentino, C. Chabartier, Laurent Villain-Coquet, Jean-Louis Ferge, Y. Brouste, Bruno Megarbane, Hossein MehdaouiS48 Incubation of immune cells in septic plasma: effect on glucose utilization and on phenotypic expression on monocytes, polymorphonuclears and lymphocytesBenjamin Soyer, Valérie Faivre, Charles Damoisel, Anne-Claire Lukaszewicz, Didier Payen de la GaranderieS49 Ex vivo effects of hyperglycemia on phenotype and production of reactive oxygen species by the NADPH oxidase of human immune cells in acute inflammatory responseBenjamin Soyer, Valérie Faivre, Charles Damoisel, Anne-Claire Lukaszewicz, Didier Payen de la GaranderieS52 HMGB1 induces neutrophils dysfunction after septic shockFabrice Uhel, Murielle Gregoire, Arnaud Gacouin, Caroline Piau, Yves Le Tulzo, Karin Tarte, Jean-Marc TadiéS53 Rapid mobilization of myeloid-derived suppressor cells during sepsis and relation with clinical courseThomas Daix, Robin Jeannet, Emmanuelle Begot, Nicolas Pichon, Anne-Laure Fedou, Estelle Guérin, Philippe Vignon, Jean Feuillard, Bruno FrançoisS54 Targeted endothelial TREM-1 deletion protects mice during septic shockLucie Jolly, Amir Boufenzer, Jérémie Lemarie, Kevin Carrasco, Marc Derive, Sebastien GibotS55 Polymicrobial sepsis inhibits tumor growth in cancer miceHamid Merdji, Jean-François Llitjos, Christophe Rousseau, Nadia Belaidouni, Julie Toubiana, Jean-Paul Mira, Jean-Daniel Chiche, Frédéric PèneS56 Telestroke implementation in the biggest French region (12 millions inhabitants): the project ORTIFYann L'Hermitte, France Woimant, Catherine Oppenheim, Christophe Couvreur, François DolveckS57 Free haemoglobin concentration in patients with sickle cell disease referred to the emergency room: Is it useful?Pierre Mora, Magali Devriese, Sophie Dupeyrat, Patrick Ray, Guillaume Lefevre, Muriel FartoukhS58 Evaluation of the prescription and use of antibiotics in an emergency department of a general hospital by Gyssens MethodNicolas Roothaer, Amélie Carpentier, Fabien Vaniet, Antoine Maisonneuve, Eric WielS59 High dosages of norepinephrine in trauma patientsSébastien Canu, Emmanuelle Hammad, Francois Antonini, Marion Poirier, Laurent Zieleskiewicz, Coralie Vigne, Malik Haddam, Julie Alingrin, Marc LeoneS60 Bleeding risk of pleural procedures in patients taking antiplatelet therapy: a multicentric prospective studyLaurence Dangers, Gilles Mangiapan, Mikael Alves, Naïke Bigé, Jonathan Messika, Elise Morawiec, Mathilde Neuville, Christophe Cracco, Gaetan Beduneau, Nicolas Terzi, Isabelle Huet, Xavier Dhalluin, Nathalie Bautin, Jean Jacques Quiot, Corinne Appere De Vecchi, Thomas Similowski, Cécile ChenivesseS61 Interest of the association fibrinogen/tranexamic acid in the management of severe postpartum hemorrhageKhalil Tarmiz, Fehmi Ferhi, Hosni Khouadja, Affra Brahim, Mohamed Amine Bouslama, Khaled BenjaziaS62 HELLP syndrome in ICU: epidemiological, clinical and prognostic study about 112 casesFatma Kaaniche Medhioub, Kais Rgieg, Olfa Turki, Mariem Smaoui, Anis Chaari, Benhamida Chokri, Mabrouk Bahloul, Bouaziz MounirS63 Neurological complications in eclampsiaChaigar Mohammed Cheikh, I. Moussaid, Kamal Belkadi, E. El Alami, S. El Youssoufi, S. SalmiS64 Brain water contain is dependent on plasmatic ammonemia levels in hyperammoniemic encephalopathy, a quantitative CT scan studyNicolas Weiss, Fanny Mochel, Damien Galanaud, Louis Puybasset, Dominique Thabut, Brain Liver Pitié-Salpêtrière Study Group (BLIPS), Paris, FranceS65 Sodium phenylbutyrate administration to avoid neurological worsening in hepatic encephalopathy patients in ICUSimona Tripon, Marion Lodey, Elsa Guiller, Maxime Mallet, Marika Rudler, Dominique Thabut, Nicolas Weiss, Brain Liver Pitié-Salpêtrière Study Group (BLIPS), Paris, FranceS66 Disruption of posteromedial large-scale neural communication predicts recovery from comaStein Silva, Béatrice Riu-Poulenc, Jean Ruiz, Corine Vuillaume, Francesco De Pasquale, Jean Francois DemonetS67 Loss of sleep elements on continuous EEG monitoring is associated with mortality in patients with cardiogenic shock requiring veno-arterial extra-corporeal membrane oxygenation (ECMO)Fabrice Sinnah, Marie Amelie Dalloz, Eric Magalhaes, Mathilde Neuville, Roland Smonig, Aguila Radjou, Bruno Mourvillier, Lila Bouadma, Jean-François Timsit, Marie Pia D'ortho, Anny Rouvel-Tallec, Romain SonnevilleS68 Protective effects of high-density lipoprotein therapy in a mouse model of ischemic stroke hemorrhagic transformation due to acute hyperglycemiaDavid Couret, Aurélie Catan, Brice Nativel, Cynthia Planesse, Nicolas Diotel, Olivier MeilhacS69 Glucocorticoids as a "rescue therapy" for delayed intracranial hypertension after acute brain injury: a retrospective studyFabian Roy-Gash, Stephane Welschbillig, Elodie Lang, Christophe Lebard, Nicolas EngrandS70 Organ donation: early talks (ET) to relatives before occurence of brain deathAnne-Gaelle Si Larbi, Virginie Gaudin, France Bonnin, Oceane Sultan,, Alexis Soummer, Grégoire Trebbia, Cecile Hoc, Emmanuel Mathieu, Bertrand Lapergue, Frederic Bourdain, Charles CerfS71 Remifentanil target-controlled infusion for procedures generating pain or discomfort in the ICU: feasibility, safety and tolerance evaluationMargot Caron, Antoine Parrot, Maxens Decavèle, Clarisse Blayau, Jean-Pierre Fulgencio, Vincent Labbe, Michel Djibre, El Mahdi Hafiani, Christophe Quesnel, Muriel Fartoukh, Tai PhamS72 Minimizing dead-volume infusion devices leads to a reduction in hypoglycaemia in surgery patients admitted to a perioperative intensive care unitStephanie Genay, Bertrand Décaudin, Sabine Ethgen, Pascal Odou, Gilles LebuffeS73 Patient-important outcomes in randomized controlled trials in critically ill patientsStéphane Gaudry, Jonathan Messika, Jean-Damien Ricard, Blandine Pasquet, Sylvie Guillo, Emeline Dubief, Didier Dreyfuss, Florence TubachS74 Epidemiology of platelets transfusion in critically ill patientsCécile Aubron, Andrew Flint, Michael Bailey, Rinaldo Bellomo, David Pilcher, Allen Cheng, Colin Hegarty, Anthony Martinelli, Benjamin Howden, Michael Reade, Zoe McquiltenS75 Outcome of selected nonagenarians admitted in ICUs: a multicenter study from the Outcomerea research groupMaïté Garrouste-Orgeas, Stephane Ruckly, Francois Philippart, Anne Sylvie Dumenil, Dany Goldgran Toledano, Samir Jamali, Carole Schwebel, Lilia Soufir, Christophe Clec'h, Michaël Darmon, Bernard Allaouchiche, Laurent Argaud, Bruno Verdière, Muriel Fartoukh, Mélanie Cherin, Elie Azoulay, Jean-François TimsitS76 A systematic follow-up consultation guarantee quality of care in intensive care unitMartine Nyunga, Noémie Banaias, Clément Vanbaelinghem, Céline Broucqsault-Dedrie, Delphine Colling, Marie Kauv, Erik Blondeau, Patrick HerbecqS77 Change in functional autonomy following ICU stayIslem Ouanes, Mahdi Marzouk, Lamia Ouanes-Besbes, Rami Jabla, Chaima Ghribi, Nesrine Boujelbene, Asma Hachani, Saousen Ben Abdallah, Hedia Hammed, Hend Ben Lakhal, Imen Ben Ali, Imen Abdellaoui, Fahmi Dachraoui, Fekri AbrougS78 Outcome of Intensive Care Unit (ICU) elderly patients admitted with solid tumorEdouard Auclin, Emmanuel Guérot, Caroline Haw-Berlemont, Julien Taieb, Stéphane Oudard, Jean-Luc Diehl, Jean-Yves Fagon, Nadia AissaouiS79 Risks factors for mortality in critically ill children with acute kidney injury requiring renal replacement therapyGenevieve Morissette, Wassim Kechaou, Catherine Litalien, Aïcha Merouani, Véronique Phan, Josée Bouchard, Philippe JouvetS80 Epinephrine use in pediatric septic shock: a retrospective, single-center study on 117 patientsJulie Starck, Mehdi Oualha, Nelly Briand, Jean-Marc Treluyer, Sylvain Renolleau, Laurent DupicS81 Sickle cell disease in pediatric intensive care unit: a five-year retrospective monocentric study of 74 patientsPhilippe Sachs, S Julliand, François Angoulvant, Julie Sommet, L Holvoet, M Benkerrou, Stéphane DaugerS82 Implementation and evaluation of a paediatric nurse-driven sedation protocol in a PICULélia Dreyfus, Fabienne Bordet, Sandrine Touzet, Angélique Denis, Etienne JavouheyS83 Diagnostic evaluation and management of new-onset seizures and seizures with known epilepsy in children: a retrospective and comparative analysisJulien Le Coz, Gérard Chéron, Rima Nabbout, Geraldine Patteau, Claire Heilbronner, Philippe Hubert, Sylvain Renolleau, Mehdi OualhaS84 MRI sedation in children in pediatric hospital in Oran, AlgeriaNabil Tabet Aoul, zakaria addou, Ali Douah, Mohamed Moussati, Kamel Belhabiche, Nabil AouffenS85 Neurally adjusted ventilatory assist in pediatric patients following cardiac surgery: feasibility in clinical practice and impact on ventilation pressuresBenjamin Crulli, Baruch Toledano, Nancy Poirier, Suzanne Vobecky, Guillaume EmeriaudS86 Percutaneous central venous cannulation: a Seldinger technique versus an ultrasound guidance technique in a pediatric intensive care unitFehmi Ferhi, Hosni Khouadja, Mohamed Amine Bouslama, Affra Brahim, Khalil Tarmiz, Khaled BenjaziaS87 Effect of remote ischemic preconditioning on renal resistive index in healthy volunteersRené Robert, M. Vinet, Angéline Jamet, Remi Coudroy, Arnaud W. ThilleS88 Peak concentration of high-dose AMIKACIN does not affect renal recovery at day 90: a retrospective study of 93 patients in a single medical Intensive Care UnitCamille Vinclair, Romain Sonneville, Bruno Mourvillier, Mathilde Neuville, Roland Smonig, Eric Magalhaes, Guillaume Voiriot, Aguila Radjou, Jean-François Soubirou, Stephane Ruckly, Lila Bouadma, Jean-François TimsitS89 Resuscitating chronic hypertensive patient with a high mean arterial pressure target during septic shock protects against acute renal failureJulie Boisramé-Helms, Ferhat Meziani, Jean-François Hamel, François Beloncle, Jean-Louis Teboul, Peter Radermacher, Pierre AsfarS90 Guidewire exchange vs new-site placement for temporary dialysis catheters insertion in ICU patients: Is there a greater risk of colonization or dysfunction?Elisabeth Coupez, Jean-François Timsit, Stephane Ruckly, Carole Schwebel, Didier Gruson, Emmanuel Canet, Kada Klouche, Laurent Argaud, Julien Bohé, Maïté Garrouste-Orgeas, François Vincent, Sophie Cayot, Michaël Darmon, Alexandre Boyer, Elie Azoulay, Lila Bouadma, Alexandre Lautrette, Bertrand SouweineS92 Assessment of chloride levels on renal function after cardiac arrestCláudia Righy Shinotsuka, Pietro Caironi, Paola Villois, Vito Fontana, Jean-Louis Vincent, Jacques Creteur, Fabio Silvio TacconeS93 Sustained low-efficiency dialysis with regional citrate anticoagulation is safe for patients with acute liver failure or cirrhosisFranck Pourcine, Ly Vong, Jonathan Chelly, Sebastien Jochmans, Oumar Sy, Olivier Ellrodt, Nathalie Rolin, Jean-Emmanuel Alphonsine,, Claire Marie Weyer, Jean Serbource-Goguel, Benoit Akando, Razach Abdallah, Mehran Monchi, Christophe VinsonneauS94 The new biomarker Nephrocheck™ can discriminate the population of septic shock patients with an AKIN 1 or 2 acute renal failure who will not progress toward the AKIN 3 levelMorgane Wetzstein, Loay Kontar, Dimitri Titeca, François Brazier, Bertand De Cagny, Gaelle Bacari-Risal, Antoine Riviere, Michel Slama, Julien MaizelS95 Is thrombocytopenia an early prognostic marker in septic shock?Nadiejda Antier, Christine Binquet, Sandrine Vinault, Ferhat Meziani, Julie Boisramé-Helms, Jean-Pierre QuenotS96 Assessment of fibrinolysis in critically ill patientsYasmina Serroukh, Karim Zouaoui Boudjeltia, Anne Joosten, Alexandre Rousseau, Patrick Biston, Michael PiagnerelliS97 Early detection of disseminated intravascular coagulation during septic shock: a multicentre prospective studyXavier Delabranche, Jean-Pierre Quenot, Thierry Lavigne, Emmanuelle Mercier, Bruno François, François Severac, Lélia Grunebaum, Laure Stiel, Florence Toti, Ferhat Meziani, Julie Boisramé-Helms, CRICS NetworkS98 Activation or dysregulation of coagulation during septic shock: How to stratify patients in 2016?Xavier Delabranche, Thierry Lavigne, Laure Stiel, Julie Boisramé-Helms, Achille Kouatchet, Maleka Schenck, Lélia Grunebaum, Yoganaden Mootien, Nicolas Lerolle, Ferhat MezianiS99 Associated factors to early high blood pressure after weaning vasopressors during septic shockRostane Gaci, Jean-Romain Garric, Damien Barraud, Marie Conrad, Aurélie Cravoisy-Popovic, Jérémie Lemarie, Charles-Henri Maigrat, Pierre-Edouard Bollaert, Sébastien GibotS100 Impact of endotracheal intubation on septic shock outcome: a post hoc analysis of the SEPSISPAM trialAgathe Delbove, Cédric Darreau, Nicolas Lerolle, Pierre Asfar, CNER DESC réanimation grand ouestS101 Corporal Contention at the Onset of Septic shock (COCOONs): study protocol and preliminary results of a phase II trialAuguste Dargent, Audrey Large, Agnès Soudry-Faure, Sebastien Prin, Pierre-Emmanuel Charles, Jean-Pierre Quenot, COCOONs Study GroupS102 Veno-arterial ECMO for refractory cardiogenic shock following cardiac arrestMarc Pineton De Chambrun, Nicolas Bréchot, Guillaume Hekimian, Guillaume Lebreton, Matthieu Schmidt, Pierre Demondion, Ania Nieszkowska, Jean Louis Trouillet, Pascal Leprince, Jean Chastre, Alain Combes, Charles-Edouard LuytS103 Outcome of patients with pulmonary embolism treated by extra-corporeal life support (ECLS)Jean-Christophe Blanchard, François Belon, Sydney Chocron, Nicolas Meneveau, Loïc Barrot, Nicolas Belin, Bérengère Vivet, Guylaine Labro, Jean-Christophe Navellou, Cyrille Patry, Gaël Piton, Gilles CapellierS104 Acute massive pulmonary embolism rescued by veno-arterial extracorporeal membrane oxygenationFilippo Corsi, Guillaume Lebreton, Nicolas Bréchot, Guillaume Hékimian, Ania Nieszkowska, Charles-Edouard Luyt, Pascal Leprince, Jean Louis Trouillet, Alain Combes, Matthieu SchmidtS105 Outcome of patient recused for extracorporeal membrane oxygenation for ARDSPierre-Emmanuel Meynieu, Benjamin Repusseau, Virginie Perrier, Arnaud Germain, Antoine Dewitte, Hadrien Roze, Alexandre OuattaraS106 Refractory electrical storm rescued by venoarterial extracorporeal membrane oxygenationGuillaume Baudry, Guillaume Lebreton, Guillaume Hekimian, Nicolas Brechot, Ania Nieszkowska, Charles-Edouard Luyt, Jean Louis Trouillet, Pascal Leprince, Alain Combes, Matthieu SchmidtS107 Incidence and determinants of severe bleeding among patients with extra-corporeal membrane oxygenation (ECMO)Lucie Hierle, François Belon, Guillaume Besch, Sebastien Pili-Floury, Loïc Barrot, Bérengère Vivet, Guylaine Labro, Jean-Christophe Navellou, Cyrille Patry, Nicolas Belin, Gaël Piton, Gilles CapellierS108 Venovenous extracorporeal membranous oxygenation device-related infections and colonizationsGuillemette Thomas, Jean-Marie Forel, Nadim Cassir, Sami Hraiech, Christophe Guervilly, Fanny Klasen, Mélanie Adda, Stéphanie Dizier, Antoine Roch, Laurent PapazianS109 High emergency lung transplant for end-stage cystic fibrosis: ECMO as a bridge to transplant for patients with temporary contraindicationsGrégoire Trebbia, Kiruba Govindaradjou, Alexis Soummer, Jérôme Devaquet, Clément Picard, Antoine Roux, François Parquin, Elise Cuquemelle, Morgan Leguen, Marie-Louise Felten, Edouard Sage, Alain Chapelier, Charles CerfS110 Malignant acute respiratory distress syndrome in diffuse lepidic adenocarcinoma (DLA): diagnosis and current issuesMaxens Decavèle, Antoine Parrot, Michael Duruisseaux, Jocelyne Fleury, Martine Antoine, Marie-France Carette, Marie Wislez, Muriel FartoukhS111 Acute respiratory failure from pulmonary leukemic infiltrates: diagnosis contribution of high-resolution computed tomography (HRCT)Claire Givel, Virginie Lemiale, Constance De Margerie-Mellon, Etienne Lengliné, Leïla Mourtada, François Vincent, Akli Chermak, Eric De Kerviler, Elie AzoulayS112 Characteristics and outcome of patients with interstitial lung disease admitted to the intensive care unit over a 15-year periodYacine Tandjaoui-Lambiotte, Frédéric Gonzalez, Olivia Freynet, Guillaume Van Der Meersch, Johanna Oziel, Christophe Huang, Philippe Karoubi, Christophe Clec'h, Yves CohenS113 Outcome of patients admitted in intensive care unit for acute manifestation of small vessel vasculitisAntoine Kimmoun, Elisabeth Baux, Vincent Das, Nicolas Terzi, Patrice Talec, Stephan Ehrmann, Guillaume Geri, Steven Grange, Nadia Anguel, Alexandre Demoule, Anne-Sophie Moreau, Elie Azoulay, Jean-Pierre Quenot, Julie Boisramé-Helms, Guillaume Louis, Romain Sonneville, Nicolas Girerd, Bruno LevyS114 A monocenter retrospective study of predictive factors of prolonged intensive care unit hospitalization after a whole lung lavage procedure for patients with pulmonary alveolar proteinosisPauline Tallon, Alice Hadchouel-Duvergé, Nadège Salvi, Pascale Cairet, Jean-Marc Treluyer, Mehdi Oualha, Fabrice Lesage, Laure De Saint Blanquat, Sylvain Renolleau, Christophe Delacourt, Laurent DupicS115 Free fatty acids plasma profile during acute chest syndrome in adult patients with sickle cell disease: a pilot studyBlandine Lefebvre Blandine, Guillaume Lefevre, Laurence Beraud, Pierre Mora, Zoé Coppere, Antonin Lamaziere, François Lionnet, Muriel FartoukhS116 Extravascular lung water and lung ultrasound to predict severe primary graft dysfunction following lung transplantationSamuel Lehingue, Christophe Guervilly, Stéphanie Dizier, Laurent Zieleskiewicz, Xavier D'journo, Guillemette Thomas, Fanny Klasen, Mélanie Adda, Antoine Roch, Forel Jean-Marie, Marc Leone, Laurent PapazianS117 Results of the international multicentric prospective observational study Phase Angle Project: phase angle measured by bioimpedance analysis at intensive care unit (ICU) admission predicts 28-day survivalRonan Thibault, Anne-Marie Makhlouf, Aurélien Mulliez, Cristina Gonzalez, Sylvain Dadet, Gintautas Kekstas, Jean-Charles Preiser, Kozjek Nada Rotovnik, Isabel Ceniceros Rozalen, Kinga Kupczyk, Zeljko Krznaric, Fabienne Tamion, Noël Cano, Claude Pichard, Phase angle project InvestigatorsS118 Nutrireaped: a survey of physician nutrition practices and knowledge in French-speaking pediatric intensive care unitsBénédicte Gaillard-Le Roux, Aurelien Jacquot, Corinne Jotterand, Shancy Rooze, Clemence Moullet, Flavie Letois, Frederic VallaS119 A computerized tool increases compliance to caloric and protein targets and may lower mortality in neutropenic hematologic patients in the ICU: the NUTCHOCO study: NUTritionnal Care in Hematologic Oncologic patients and Critical OutcomeAurélia Henin, Florence Ettori, Christophe Zemmour, Laurent Chow-Chine, Jeanpaul Brun, Antoine Sannini, Magali Bisbal, Marion Faucher, Jean Marie Boher, Djamel MokartS120 Systemic evaluation of intakes in patients receiving noninvasive ventilation: the STARVE studyMichel Arnaout, Aude Marincamp, Matthieu Reffienna, Anne-Sophie Debue, Pierre Lucas, Audrey Feltry, Julien Charpentier, Benoit Champigneulle, Wulfran Bougouin, Guillaume Geri, Frédéric Pène, Jean-Paul Mira, Alain Cariou, Jean-Daniel Chiche, Groupe de travail sur la ventilationS121 Computerized glucose control in the ICUSalah Adel Ben, Juliette Audibert, Alexandre Conia, Olivier Gontier, Mouldi Hamrouni, Thierry Lherm, Abdelkader Ouchenir, Jérôme Rétif, Alain Proudhom, Chantal Lagardere, Stéphane Tissot, Pierre KalfonS122 Toxicodynetics in mono-intoxications with oxazepam and nordiazepam: an approach to a better understanding of drug-drug interactionLynn Sacre, Antoine Villa, Alaywa Khadija, Robert Garnier, Frederic BaudS123 Rapid triage of victims suspected of a chemical attack: a one-page sheet allowing identifying the toxidrome: the doctors without borders (MSF) experienceFrederic Baud, Robert Garnier, Brigitte Vasset, Annette HeinzelmanS124 Low sensitivity of toxicological analysis in daily practice of acute poisonings: an endless rupture in spite of modern technologyFrederic Baud, Alaywa Khadija, Romain Jouffroy, Lionel LamhautS125 Context of the request and interest of toxicological screening in a medical intensive care unitElsa Démarest Durand, Fabienne Tamion, Christophe Girault, Gaetan Beduneau, Dorothée Carpentier, Patricia Compagnon, Steven GrangeS126 Acute poisoning in emergency departmentNeila Maaroufi, Dhaouadi MahassenS127 Management of poising: Are there differences between specialised and non-specialised emergencies?A M'rad, Alia Jebri, Youssef Blel, Hend Ben Lakhal, Messaouda Khelfa, Nozha Brahmi, H ThabetS128 Jusquiame poisoning: report of a family intoxicationHassen Ben Ghezala, Salah Snouda, Rebeh Daoudi, Moez KaddourS129 Morbi-mortality of poisoning episodes in Paris region: a test for a multisource surveillance systemCéline Legout, Robert Garnier, Antoine Villa, Frederic Baud, Philippe Aegerter, Anne Castot-VillepeletS130 Atypical pneumonia in the ICU: a retrospective multicentric studySandrine Valade, Virginie Lemiale, Laurent Argaud, Frédéric Pène, Laurent Papazian, Fabrice Bruneel, Amélie Seguin, Achille Kouatchet, Johanna Oziel, Olivier Lesieur, Florence Boissier, Bruno Megarbane, Naïke Bigé, Noelle Brule, Anne-Sophie Moreau, Alexandre Lautrette, Elie AzoulayS131 Severe leptospirosis: analysis of mortality and organ failures in 134 patients hospitalized in intensive care unitBenjamin Delmas, Julien Jabot, Paul Chanareille, Jérôme Allyn, Nicolas Allou, Cyril Ferdynus, Bernard-Alex Gauzere, Olivier Martinet, David VandrouxS132 In severe pneumonia, respiratory viruses are not passengers but pathogensGuillaume Voiriot, Benoit Visseaux, Johana Cohen, Liem Binh Luong Nguyen, Mathilde Neuville, Caroline Morbieu, Charles Burdet, Aguila Radjou, François-Xavier Lescure, Roland Smonig, Laurence Armand-Lefevre, Bruno Mourvillier, Yazdan Yazdanpanah, Jean-François Soubirou, Stephane Ruckly, Nadira Houhou-Fidouh, Jean-François TimsitS133 Critical care management of patients with HHV8-associated disordersMarine Cazaux, Claire Pichereau, Marion Venot, Sandrine Valade, Virginie Lemiale, Akli Chermak, Emmanuel Canet, Le Goff Jérôme, Veronique Meignin, David Boutboul, Lionel Galicier, Elie Azoulay, Eric MariotteS134 Emerging moulds in critically ill patients: epidemiological trends, clinical features and ICU outcomeLaura Platon, Philippe Rispail, Vincent Brunot, N. Besnard, Patrice Ceballos, Kada KloucheS135 Intensive care unit-associated bloodstream infection and ventilator-associated pneumonia in critically ill cancer patients: a 12-year retrospective studyAnnabelle Stoclin, Federico Rotolo, Muriel Wartelle, Yosr Hicheri, Sylvia Maillet, Elisabeth Chachaty, Jean-Pierre Pignon, François BlotS136 Is diabetes mellitus a risk factor for intensive care unit-acquired infections?Marion Venot, Stephane Ruckly, Christophe Clec'h, Michaël Darmon, Bernard Allaouchiche, Dany Goldgran Toledano, Maïté Garrouste-Orgeas, Christophe Adrie, Jean-François Timsit, Elie AzoulayPHYSIOTHERAPISTS ABSTRACTSO85 Short-term physiological effects of nasal high-flow in healthy subjects. Impact of flow rates on the work of breathingMathieu Delorme, Pierre Alexandre Bouchard, Mathieu Simon, François LelloucheO86 High-flow therapy allows a decreased workload of accessory respiratory musclesEmilie Bialais, Dupuis Julie, Laura Paoloni, Gregory Reychler, Xavier WittebolleO87 Patient perception and feasibility of early mobilization in the critically illCheryl Hickmann, Diego Castanares-Zapatero, Emilie Bialais, Jonathan Dugernier, Antoine Tordeur, Lise Colmant, Xavier Wittebole, Giuseppe Tirone, Jean Roeseler, Pierre-François LaterreP252 Early rehabilitation in critically ill patients: a prospective multicenter assessment of real-life practiceLorraine Ducroux, Sylvie L'hotellier, Elodie Baumgarten, Stéphanie Borschneck, Francis Schneider, Vincent CastelainP253 Motor imagery and functional magnetic resonance imagingClaire Kemlin, Eric Moulton, Charlotte RossoP254 Thoracic ultrasound: potential new tool for physiotherapists in respiratory management-a narrative reviewAymeric Le Neindre, Silvia Mongodi, Francois Philippart, Béaïd BouhemadP255 In vitro comparison of a vibrating-mesh nebulizer operating in expiratory synchronized and inspiratory nebulization modes during noninvasive ventilationJoana Rodrigues, Caroline Botteau, Jonathan Dugernier, Giuseppe Liistro, Gregory Reychler, Jean-Bernard MichotteP256 Evaluation of a new system of oxygen administration: the Wenoll systemFrédéric Duprez, François Waroquier, Karel Christiaens, Grégory Cuvelier, Frank Vantrimpont, Sharam MachayeckhiP257 Evaluation of three portable oxyconcentrators in high altitudeFrédéric Duprez, François Waroquier, Karel Christiaens, Grégory Cuvelier, Charbel Elkhawand, Frank Vantrimpont, Sharam Machayeckhi, Frank Vermeesh.

2016Jun
J. Neurol.
J Neurol 2016 Jun 17. Epub 2016 Jun 17.
Department of Neurology and Immunology, Erasmus MC University Medical Centre Rotterdam, PO Box 2040, 3000 CA, Rotterdam, Netherlands.

Guillain-Barré syndrome (GBS) is an acute-onset, immune-mediated disorder of the peripheral nervous system. In early GBS, arbitrarily established up to 10 days of disease onset, patients could exhibit selective manifestations due to involvement of the proximal nerves, including nerve roots, spinal nerves and plexuses. Such manifestations are proximal weakness, inaugural nerve trunk pain, and atypical electrophysiological patterns, which may lead to delayed diagnosis. Read More

The aim of this paper was to analyze the nosology of early GBS reviewing electrophysiological, autopsy and imaging studies, both in acute inflammatory demyelinating polyneuropathy (AIDP) and acute motor/motor-sensory axonal neuropathy (AMAN/AMSAN). Early electrophysiology showed either well-defined demyelinating or axonal patterns, or a non-diagnostic pattern with abnormal late responses; there may be attenuated M responses upon lumbar root stimulation as the only finding. Pathological changes predominated in proximal nerves, in some studies, most prominent at the sides where the spinal roots unite to form the spinal nerves; on very early GBS endoneurial inflammatory edema was the outstanding feature. In the far majority of cases, spinal magnetic resonance imaging showed contrast enhancement of cauda equina, selectively involving anterior roots in AMAN. Both in AIDP and AMAN/AMSAN, ultrasonography has demonstrated frequent enlargement of ventral rami of C5-C7 nerves with blurred boundaries, whereas sonograms of upper and lower extremity peripheral nerves exhibited variable and less frequent abnormalities. We provide new insights into the pathogenesis and classification of early GBS.

2016Jun
Pract Neurol
Pract Neurol 2016 Jun 16. Epub 2016 Jun 16.
Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford, UK.

A 71-year-old woman presented with severe back pain, limb weakness and cranial nerve dysfunction associated with high cerebrospinal fluid (CSF) protein; we diagnosed Guillain-Barré syndrome and her symptoms completely resolved after intravenous immunoglobulin. Over the next 4 years, she had three further episodes of excruciating back pain accompanied by raised CSF protein, but without weakness, sensory loss, or abnormalities in routine nerve conduction studies. Sensory evoked potentials suggested proximal demyelination and lumbosacral plexus imaging suggested inflammation. Read More

We argue that this is a relapsing proximal polyradiculoneuropathy on the spectrum of chronic inflammatory demyelinating polyradiculoneuropathy.

2016Jun
Plast. Reconstr. Surg.
Plast Reconstr Surg 2016 Jun 8. Epub 2016 Jun 8.
1Department of Otolaryngology, Massachusetts Eye and Ear Infirmary and Harvard Medical School, Boston, MA.

Bilateral facial palsy is a rare clinical entity caused by myriad disparate conditions requiring different treatment paradigms. Lyme disease, Guillain-Barré syndrome, and leukemia are several examples. Herein, we describe the etiology, initial diagnostic approach, and management of long-term sequelae of bilateral paralysis that has evolved in our center over the past 13 years. Read More


A chart review was performed to identify all patients diagnosed with bilateral paralysis at our center between January 2002 and January 2015. Demographics, signs and symptoms, diagnosis, initial medical treatment, interventions for facial reanimation, and outcomes were reviewed.
Of the 2471 patients seen at our center, 68 (3%) patients with bilateral facial paralysis were identified. Ten patients (15 %) presented with bilateral facial paralysis due to Lyme disease, nine (13%) with Moebius syndrome, nine (13%) with neurofibromatosis type 2, five (7%) with BFP due to brain tumor, four (6%) with Melkersson-Rosenthal Syndrome (MRS), three (4%) due to bilateral temporal bone fractures, two (3%) with Guillain Barre Syndrome (GBS), one (2%) with CNS lymphoma, one (2%) with HIV infection, and 24 (35%) patients with presumed Bell's palsy. Treatment included pharmacologic therapy, physical therapy (PT), chemodenervation, and surgical interventions.
Bilateral facial palsy is a rare medical condition, and treatment often requires a multidisciplinary approach. We outline diagnostic and therapeutic algorithms of a tertiary care center to provide clinicians with a systematic approach to managing these complicated patients.

2016Apr
Indian J Crit Care Med
Indian J Crit Care Med 2016 Apr;20(4):238-41
Intensive Care Unit, Royal Adelaide Hospital, Adelaide, SA 5000, Australia.
2016Jun
BMC Vet. Res.
BMC Vet Res 2016 14;12(1):111. Epub 2016 Jun 14.
Departament of Internal Medicine/Neurology, Faculty of Veterinary Medicine, University of Agricultural Sciences and Veterinary Medicine "Ion Ionescu de la Brad", 8 M. Sadoveanu Alley, 700489, Iasi, Romania. gsolcan@uaiasi.ro.

Acute Idiopathic Polyradiculoneuritis, an animal model for the axonal form of the Guillain - Barre Syndrome in humans and the acquired myasthenia gravis are different autoimmune disorders affecting the peripheral nerves and the neuromuscular junction, respectively. Both lead to muscle weakness and possible respiratory failure. The coexistence of these two entities combined in the same patient is rare in humans and, to our knowledge, the present case is the first reported in dogs. Read More


An 11-year-old West Highland WhiteTerrier female dog was referred to our clinic with a history of symmetrical weakness beginning with the pelvic limbs and evolving cranially, progressing to non-ambulatory flaccid tetraparesis over the preceding week. The history did not reveal signs of a recent other illness, trauma or exposure to a neurotoxin or raccoon bite. The last vaccination was carried out 5 months before presentation. Upon clinical examination, spinal reflexes and postural reactions were decreased in all four limbs and became absent within the following 24 h; perineal reflex was normal, and loss of voice was observed. The patient maintained its ability to urinate and defecate and it had no difficulty to eat or to drink. There were no cerebellar or sensory deficits. The electrophysiological findings revealed positive sharp waves and complex repetitive discharges on the electromyogram, temporal dispersion of compound muscle action potentials associated with polyphasia and a slow motor nerve conduction velocity as signs of demyelination, and an increased latency of F-waves. The cerebrospinal fluid had a normal cellularity with increased protein content. A reduction by 18 % in the amplitudes of the third compound muscle action potential as compared to the first one was observed during a repetitive nerve stimulation, indicating a postsynaptic disturbance. Only the motor electrophysiology was considered in this study. The diagnosis was based on clinical and electrophysiological findings associated with a positive titer for acetylcholine receptor antibodies.
The diagnosis of MG was based on the typical clinical findings such as dysphonia and dysphagia, decremental response of RNS and positive AChRs antibody titre. Flaccid tetraparesis associated with diminished reflexes, increase of the distal latencies and temporal dispersion which caused lower MNCV, along with the increase of the F wave latencies supported the diagnosis of AIP. A cerebrospinal fluid tap indicated an albuminocytologic dissociation sustaining the radicular implication of AIP. As such, a diagnosis of MG and AIP co-occurrence syndrome was established.

2016Jul
J Clin Med Res
J Clin Med Res 2016 Jul 29;8(7):555-9. Epub 2016 May 29.
Department of Neurology, The Affiliated Hospital of Weifang Medical University, Weifang 261031, China.

We recently encountered a patient with acute inflammatory demyelinating polyneuropathy (AIDP) that was associated with systemic lupus erythematosus (SLE). A 34-year-old Chinese female with a 3-year history of SLE presented with acute bilateral leg weakness and paraparesis, and lost the ability to walk 1 day after noticing bilateral leg numbness and pain for 12 days. Physical examination revealed bilateral facial muscle paralysis, muscle strength in the legs with graded 1/5 proximally and 2/5 distally bilaterally and absence of deep tendon reflex in both knees and ankles. Read More

Paresthesia was observed in distal limbs with glove and stocking distribution. Cerebrospinal fluid analysis demonstrated albuminocytologic dissociation. Electrophysiologic survey also indicated sensory-motor demyelinating polyneuropathy. The diagnosis of SLE was established based on her initial symptoms including intermittent fevers, hair loss, oral ulcers, malar rash and arthritis affecting the elbow, wrist and hand joints; positive immunologic findings for antinuclear antibody (ANA), anti-DNA antibody, anti-Smith (anti-Sm) antibody, low serum complement levels, and the kidney biopsy specimen showed glomerular mesangial proliferation with focal endothelial cell proliferation (ISN/PPS 2004 classification lupus nephritis, class III). Treatment with intravenous immunoglobulin, methylprednisolone and cyclophosphamide resulted in clinical and electrophysiological improvement.

2016Jun
Antivir. Chem. Chemother.
Antivir Chem Chemother 2016 Jun 13. Epub 2016 Jun 13.
Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, Atlanta, USA rschina@emory.edu.

Zika virus is an emerging crisis as infection is implicated in severe neurological disorders-Guillain-Barré syndrome and fetal microcephaly. There are currently no treatment options available for Zika virus infection. This virus is part of the flavivirus genus and closely related to Dengue Fever Virus, West Nile Virus, and Japanese Encephalitis Virus. Read More

Like other flaviviruses, the Zika virus genome encodes three structural proteins (capsid, precursor membrane, and envelope) and seven nonstructural proteins (NS1, NS2A, NS2B, NS3, NS4A, NS4B, and NS5). Currently, no structural information exists on these viral proteins to facilitate vaccine design and rational drug discovery.
Structures for all Zika virus viral proteins were predicted using experimental templates available from closely related viruses using the online SwissModel server. These homology models were compared to drug targets from other viruses using Visual Molecular Dynamics Multiseq software. Sequential alignment of all Zika virus polyproteins was performed using Clustal Omega to identify mutations in specific viral proteins implicated in pathogenesis.
The precursor membrane, envelope, and NS1 proteins are unique to Zika virus highlighting possible challenges in vaccine design. Sequential differences between Zika virus strains occur at critical positions on precursor membrane, envelope, NS2A, NS3, NS4B, and NS5 as potential loci for differential pathogenesis. Druggable pockets in Dengue Fever Virus and West Nile Virus NS3 and NS5 are retained in predicted Zika virus structures.
Lead candidates for Zika virus can likely be established using NS3 and NS5 inhibitors from other flaviviruses, and the structures presented can provide opportunities for Zika virus intervention strategies.

2016Jun
Am J Occup Ther
Am J Occup Ther 2016 Jul-Aug;70(4):7004210010p1-7
Sheng Hui Liao, MS, OTR/L, is Occupational Therapist, Multilingual Therapy Associates, Brooklyn, NY.

This case report describes a unique long-term functional recovery process to promote successful community reintegration for a woman with Guillain-Barré syndrome (GBS), a rare autoimmune disease. Her main symptoms were very limited mobility and depressive symptoms due to the unknown cause of and cure for the illness. Holistic occupational strategies helped the client stabilize her emotional state, create a safe home environment, improve a communication method, increase physical activity, and promote social participation. Read More

Participation in a fall prevention clinical trial lowered her risk of falling; at 9 mo, she reached 75% of the maximum Social Integration score; at 13 mo, she reached near-normal level for activities of daily living (ADLs) and her fastest time for the Timed Up and Go test; and at 2 yr, she achieved a 100% score in instrumental ADLs. For community integration of clients with GBS, a comprehensive strategic self-management approach should be prescribed for long-term recovery.

2016Jun
Expert Rev Clin Immunol
Expert Rev Clin Immunol 2016 Jun 21:1-15. Epub 2016 Jun 21.
a Division of Rheumatology, Allergy, and Clinical Immunology , University of California Davis , Davis , CA , USA.

Guillain-Barré syndrome is a rare disease representing the most frequent cause of acute flaccid symmetrical weakness of the limbs and areflexia usually reaching its peak within a month. The etiology and pathogenesis remain largely enigmatic and the syndrome results in death or severe disability in 9-17% of cases despite immunotherapy.
In terms of etiology, Guillain-Barré syndrome is linked to Campylobacter infection but less than 0. Read More

1% of infections result in the syndrome. In terms of pathogenesis, activated macrophages and T cells and serum antibodies against gangliosides are observed but their significance is unclear. Expert commentary: Guillain-Barré syndrome is a heterogeneous condition with numerous subtypes and recent data point towards the role of ganglioside epitopes by immunohistochemical methods. Ultimately, the syndrome results from a permissive genetic background on which environmental factors, including infections, vaccination and the influence of aging, lead to disease.

2016Jun
Neurology
Neurology 2016 Jun 10. Epub 2016 Jun 10.
From the Departments of Neurology (J.H., V.V.), Radiology (J.N.), and Epidemiology and Biostatistics (I.A.), University of California, San Francisco; SEARCH (J.L.K.F., E.K., J.I., P.P., S.P., N.P.), Thai Red Cross AIDS Research Centre, Bangkok, Thailand; US Military HIV Research Program (J.A., S.J.K., B.S., L.L.J.), Walter Reed Army Institute of Research, Silver Spring; Henry M. Jackson Foundation for the Advancement of Military Medicine (J.A., S.J.K., B.S.), Bethesda, MD; Department of Radiology (S.L., M.P.), Chulalongkorn University, Bangkok, Thailand; and Department of Neurology (S.S.), Yale University, New Haven, CT.

To determine the incidence, timing, and severity of neurologic findings in acute HIV infection (pre-antibody seroconversion), as well as persistence with combination antiretroviral therapy (cART).
Participants identified with acute HIV were enrolled, underwent structured neurologic evaluations, immediately initiated cART, and were followed with neurologic evaluations at 4 and 12 weeks. Concurrent brain MRIs and both viral and inflammatory markers in plasma and CSF were obtained. Read More


Median estimated HIV infection duration was 19 days (range 3-56) at study entry for the 139 participants evaluated. Seventy-three participants (53%) experienced one or more neurologic findings in the 12 weeks after diagnosis, with one developing a fulminant neurologic manifestation (Guillain-Barré syndrome). A total of 245 neurologic findings were noted, reflecting cognitive symptoms (33%), motor findings (34%), and neuropathy (11%). Nearly half of the neurologic findings (n = 121, 49%) occurred at diagnosis, prior to cART initiation, and most of these (n = 110, 90%) remitted concurrent with 1 month on treatment. Only 9% of neurologic findings (n = 22) persisted at 24 weeks on cART. Nearly all neurologic findings (n = 236, 96%) were categorized as mild in severity. No structural neuroimaging abnormalities were observed. Participants with neurologic findings had a higher mean plasma log10 HIV RNA at diagnosis compared to those without neurologic findings (5.9 vs 5.4; p = 0.006).
Acute HIV infection is commonly associated with mild neurologic findings that largely remit while on treatment, and may be mediated by direct viral factors. Severe neurologic manifestations are infrequent in treated acute HIV.

2016Jun
Br. Med. Bull.
Br Med Bull 2016 Jun 9. Epub 2016 Jun 9.
Division of Infectious Diseases, University Medicine Cluster, National University Health System, 1E Kent Ridge Road, Level 10, 119228, Singapore Yong Loo Lin School of Medicine, National University of Singapore, 1E Kent Ridge Rd 119228, NUHS Tower Block, Level 11, Singapore 117597, Singapore.
2016May
Epidemiol Health
Epidemiol Health 2016 May 31. Epub 2016 May 31.
Oswaldo Cruz Foundation, Evandro Chagas National Institute of Infectious Diseases and Bio-Manguinhos, Rio de Janeiro, Brazil.

Zika virus, which was first discovered in 1947, has become a global threat to human health as it is rapidly spreading through Latin America, the Caribbean, the US and Asia, after causing a large outbreak in the northeast part of Brazil in 2015. There is ample evidence to support that Zika virus is associated with neurological complications such as microcephaly. The review aims to provide an overview on the complex issues involved in the emergence of Zika virus's neurological disorders and to discuss possible explanations of Zika virus introduction and dissemination in Brazil. Read More

We also suggest a way to adequately respond to the Zika virus emergence.
The studies on Zika virus disease coupled with the statistics in Brazil showed that Zika virus is associated with neurological disorders such as microcephaly and Guillain-Barré Syndrome. Based on phylogenetic and molecular analysis, the hypothesis regarding the introduction of Zika virus is that the international events happened in 2013 and 2014, during which many foreigners have visited Brazil, could have brought Zika virus into Brazil. The immunologically naïve status of populations in the Americas, previous infection with dengue virus, and the increased activity of Aedes aegypti might be the contributing factors for such an outbreak in Brazil. The Zika virus emergence emphasized the importance of crossdisciplinary perspective. Beside the scientific vector control strategies, it is important to understand the nature of opportunistic evolution in the complex ecosystem and to have social and anthropological knowledge in order to properly respond to the spread of Zika virus.
The experiences of Brazil have demonstrated the significance of multidisciplinary approach in response to new and resurgent arboviral diseases and provided important lessons that could be applied to other developing countries.

2016Jun
Lancet Infect Dis
Lancet Infect Dis 2016 Jun 6. Epub 2016 Jun 6.
Institute of Molecular Biosciences, Mahidol University, Salaya, Nakhon Pathom 73170, Thailand; Center for Emerging and Neglected Infectious Diseases, Mahidol University, Salaya, Nakhon Pathom 73170, Thailand. Electronic address: duncan.smi@mahidol.ac.th.
2016Jul
Clin. Microbiol. Rev.
Clin Microbiol Rev 2016 Jul;29(3):659-94
Institute of Microbiology, Faculty of Biology and Medicine, University of Lausanne and University Hospital, Lausanne, Switzerland Materno-fetal and Obstetrics Research Unit, Department Femme-Mère-Enfant, University of Lausanne and University Hospital, Lausanne, Switzerland david.baud@chuv.ch.

The rapid spread of the Zika virus (ZIKV) in the Americas and its potential association with thousands of suspected cases of microcephaly in Brazil and higher rates of Guillain-Barré syndrome meet the conditions for a Public Health Emergency of International Concern, as stated by the World Health Organization in February 2016. Two months later, the Centers for Disease Control and Prevention (CDC) announced that the current available evidence supports the existence of a causal relationship between prenatal Zika virus infection and microcephaly and other serious brain anomalies. Microcephaly can be caused by several factors, and its clinical course and prognosis are difficult to predict. Read More

Other pathogens with proven teratogenicity have been identified long before the current ZIKV epidemic. Despite the growing number of cases with maternal signs of infection and/or presence of ZIKV in tissues of affected newborns or fetuses, it is currently difficult to assess the magnitude of increase of microcephaly prevalence in Brazil, as well as the role of other factors in the development of congenital neurological conditions. Meanwhile, health agencies and medical organizations have issued cautious guidelines advising health care practitioners and expectant couples traveling to, returning from, or living in affected areas. Analogous to dengue virus (DENV) epidemics, ZIKV has the potential to become endemic in all countries infested by Aedes mosquitoes, while new mutations could impact viral replication in humans, leading to increased virulence and consequently heightened chances of viral transmission to additional naive mosquito vectors. Studies are urgently needed to answer the questions surrounding ZIKV and its role in congenital neurological conditions.

Zika virus (ZIKV) is an arbovirus belonging to the genus Flavivirus (family Flaviviridae) and was first described in 1947 in Uganda following blood analyses of sentinel Rhesus monkeys. Until the twentieth century, the African and Asian lineages of the virus did not cause meaningful infections in humans. However, in 2007, vectored by Aedes aegypti mosquitoes, ZIKV caused the first noteworthy epidemic on the Yap Island in Micronesia. Read More

Patients experienced fever, skin rash, arthralgia and conjunctivitis. From 2013 to 2015, the Asian lineage of the virus caused further massive outbreaks in New Caledonia and French Polynesia. In 2013, ZIKV reached Brazil, later spreading to other countries in South and Central America. In Brazil, the virus has been linked to congenital malformations, including microcephaly and other severe neurological diseases, such as Guillain-Barré syndrome. Despite clinical evidence, direct experimental proof showing that the Brazilian ZIKV (ZIKV(BR)) strain causes birth defects remains absent. Here we demonstrate that ZIKV(BR) infects fetuses, causing intrauterine growth restriction, including signs of microcephaly, in mice. Moreover, the virus infects human cortical progenitor cells, leading to an increase in cell death. We also report that the infection of human brain organoids results in a reduction of proliferative zones and disrupted cortical layers. These results indicate that ZIKV(BR) crosses the placenta and causes microcephaly by targeting cortical progenitor cells, inducing cell death by apoptosis and autophagy, and impairing neurodevelopment. Our data reinforce the growing body of evidence linking the ZIKV(BR) outbreak to the alarming number of cases of congenital brain malformations. Our model can be used to determine the efficiency of therapeutic approaches to counteracting the harmful impact of ZIKV(BR) in human neurodevelopment.