Behcet Disease Publications (8869)


Behcet Disease Publications

Korean J. Intern. Med.
Korean J Intern Med 2017 Jan 12. Epub 2017 Jan 12.
Department of Rheumatology, Gachon University Gil Medical Center, Incheon, Korea.

The clinical manifestations of Behcet disease (BD) have been reported to differ according to country, region, and race. Gender, onset age, and human leukocyte antigen (HLA)-B51 have also been known as the factors that influence the clinical features of BD. The aim of this study is to investigate the clinical phenotypes of Korean patients who visited the rheumatology clinic with BD with respect to gender, onset age, and HLA-B51. Read More

Total 193 Korean patients (129 females and 64 males) fulfilling the international criteria for BD were retrospectively assessed.
The mean age at disease onset and disease duration of the BD patients were 32.2 ± 11.1 and 14.2 ± 9.3 years, retrospectively. Females suffered more frequently from genital ulcers (90.7% vs. 75.0%, p < 0.01), peripheral arthritis (67.4% vs. 43.8%, p < 0.01), and inf lammatory low back pain (38.8% vs. 23.4%, p = 0.03) than males, while skin involvement was more frequent in males than in females (90.6% vs. 75.2%, p = 0.01). The patients with late onset of BD (> 40 years) suffered from neurologic involvement (15.9% vs. 4.2%, p = 0.007) more frequently than those with early onset of BD. The patients with HLA-B51 showed earlier onset of disease than without HLA-B51 (28.3 ± 11.4 years vs. 33.8±11.6 years, p = 0.02) and the neurologic and gastrointestinal involvements were more frequent in the patients without HLA-B51 than with HLA-B51 (17.2% vs. 2.5%, p = 0.02 and 20.7% vs. 2.5%, p = 0.01, respectively).
The clinical phenotypes in Korean patients with BD may be influenced by gender, onset age and HLA-B51.

Asian Cardiovasc Thorac Ann
Asian Cardiovasc Thorac Ann 2017 Jan 1:218492316687177. Epub 2017 Jan 1.
5 Student Research Committee, Golestan University of Medical Sciences, Gorgan, Iran.

A 32-year-old pregnant woman, diagnosed with Behçet's disease 6 months earlier, presented with recent mild hemoptysis and exertional dyspnea. Transthoracic echocardiography showed an enlarged dysfunctional right ventricle. A large hypoechoic triangular-shaped mass was seen attached to the inner right ventricular wall, filling the cavity. Read More

No change in the size of the mass was noted after anticoagulant administration, and right heart failure progressed. Surgery was performed to remove the mass and repair the tricuspid valve. This was a very rare presentation of Behçet's disease in pregnancy, which resulted in delivery of a completely healthy baby despite corticosteroid pulse therapy and cyclophosphamide.

Joint Bone Spine
Joint Bone Spine 2017 Jan 3. Epub 2017 Jan 3.
LIRIC - Lille Inflammation Research International Center - U995, University Lille, Inserm, CHU Lille, 59000 Lille, France. Electronic address:
Adv Protein Chem Struct Biol
Adv Protein Chem Struct Biol 2017 18;106:139-189. Epub 2016 Oct 18.
Laboratory for Epigenetics and Environment, Centre National de Génotypage, CEA-Institut de Génomique, Evry, France. Electronic address:

The number of people diagnosed with chronic inflammatory diseases has increased noteworthy in the last 40 years. Spondyloarthritis (SpA), inflammatory bowel diseases (IBD), and psoriasis are the most frequent chronic inflammatory diseases, resulting from a combination of genetic predisposition and environmental factors. Epigenetic modifications include DNA methylation, histone modifications, and small and long noncoding RNAs. Read More

They are influenced by environmental exposure, life-style, and aging and have recently been shown to be altered in many complex diseases including inflammatory diseases. While epigenetic modifications have been well characterized in other diseases such as cancer and autoimmune diseases, knowledge on changes in inflammatory diseases is lagging behind with some disease-specific differences. While the DNA methylation profile of different cell types in patients with IBD has been relatively well described, less is known on changes implicated in psoriasis, and no systematic genome-wide studies have so far been performed in SpA. In this chapter, we review in detail the reported changes in patterns of DNA methylation and posttranslational histone modifications in chronic inflammatory diseases highlighting potential connections between disease-associated pathophysiological changes such as the dysbiosis of the microbiome or genetic variations associated with disease susceptibility and the epigenome. We also discuss important parameters of meaningful epigenetic studies such as the use of well defined, disease-relevant cell populations, and elude on the potential future of engineering of the epigenome in inflammatory diseases.

J Ocul Pharmacol Ther
J Ocul Pharmacol Ther 2017 Jan 4. Epub 2017 Jan 4.
1 State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University , Guangzhou, China .
Int. J. Angiol.
Int J Angiol 2016 Dec 5;25(5):e84-e86. Epub 2015 Jun 5.
Heart Institute, HaEmek Medical Center, Afula, Israel; Rappaport Faculty of Medicine, Technion, Haifa, Israel.
Ocul. Immunol. Inflamm.
Ocul Immunol Inflamm 2016 Dec 23:1-7. Epub 2016 Dec 23.
c Department of Cornea and Refractive Surgery , Narayana Nethralaya , Bangalore , India.

To study the sheathing of retinal vasculitis in various systemic autoimmune diseases using adaptive optics imaging (AOI).
Prospective, observational case series with six patients: Behçet disease (n = 1); systemic lupus erythematosus (n = 1); idiopathic retinal vasculitis (n = 2); granulomatosis with polyangiitis (n = 1); and Takayasu aorta arteritis (n = 1). Fundus photograph (FP), fundus fluorescein angiography (FFA) were done in all cases at presentation. Read More

Using the Image J software, perivascular sheathing and wall-to-wall diameter of the vessel involved were measured on AOI at time of presentation and on follow-up.
AOI was able to pick the pipe-stem sheathing in SLE and IRV(I) and parallel sheathing in rest, which correlated with FP and FFA. Moreover, the decrease and a complete resolution in the sheathing were also noted by AOI on follow-up.
AOI can be used as an additional investigative tool for diagnosis and to monitor the disease course during the treatment.

J Med Case Rep
J Med Case Rep 2016 Dec 20;10(1):360. Epub 2016 Dec 20.
Department of Neurology, Chungbuk National University College of Medicine, Chungbuk National University Hospital, 776 1Sunhwan-ro, Seowon-ku, Cheongju-si, Chungbuk, 361-711, South Korea.
Br. J. Dermatol.
Br J Dermatol 2016 Dec;175(6):e150
Department of Dermatology, Hokkaido University Graduate School of Medicine, North 15 West 7, Kita-ku, Sapporo, 060-8638, Japan.
Ann. Clin. Lab. Sci.
Ann Clin Lab Sci 2016 Dec;46(6):675-679
Department of Gastroenterology, Huadong Hospital, Fudan University, Shanghai, China