Acrodermatitis Enteropathica Publications (719)


Acrodermatitis Enteropathica Publications

J. Invest. Dermatol.
J Invest Dermatol 2016 Dec 7. Epub 2016 Dec 7.
Basic Research & Innovation Division, R&D Unit, AmorePacific Corporation, Yongin, Republic of Korea. Electronic address:
Paediatr Int Child Health
Paediatr Int Child Health 2016 Feb 26;36(1):72-5. Epub 2014 Dec 26.
Department of Paediatrics, SCB Medical College , Cuttack.

Zinc deficiency in patients with coeliac disease (CD) may result either from cumulative loss of insoluble zinc complexes or impaired zinc absorption because of damaged intestinal epithelial cell membrane. Zinc deficiency in CD is mild to moderate, though severe deficiency can occur in refractory or chronic CD cases with poor response to gluten-free diet (GFD). A boy aged 19 months presented with persistent diarrhoea, was diagnosed with CD, and developed severe zinc deficiency with acrodermatitis enteropathica-like disease while on GFD and zinc supplementation. Read More

Indian Pediatr
Indian Pediatr 2016 Aug;53(8):738-40
Departments of Neonatology, *Pediatrics and #Clinical Genetics Unit,Christian Medical College, Vellore, Tamilnadu, India. Correspondence to: Dr Benjamin Ross, Department of Neonatology, Christian Medical College, Vellore 632 004, Tamilnadu, India.

Special diet with restricted branched-chain-amino-acids used for treating maple syrup urine disease can lead to specific amino acid deficiencies.
We report a neonate who developed skin lesions due to isoleucine deficiency while using specialised formula.
Feeds were supplemented with expressed breast milk. Read More

This caused biochemical and clinical improvement with resolution of skin lesions.
Breast milk is a valuable and necessary adjunct to specialized formula in maple syrup urine disease to prevent specific amino acid deficiency in the neonatal period.


Adequate intake of zinc from the daily diet is indispensable to maintain health. However, the dietary zinc content often fails to fulfill the recommended daily intake, leading to zinc deficiency and also increases the risk of developing chronic diseases, particularly in elderly individuals. Therefore, increased attention is required to overcome zinc deficiency and it is important to improve zinc nutrition in daily life. Read More

In the small intestine, the zinc transporter, ZIP4, functions as a component that is essential for zinc absorption. In this manuscript, we present a brief overview regarding zinc deficiency. Moreover, we review a novel strategy, called "ZIP4-targeting", which has the potential to enable efficient zinc absorption from the diet. ZIP4-targeting strategy is possibly a major step in preventing zinc deficiency and improving human health.

Nippon Rinsho
Nihon Rinsho 2016 Jul;74(7):1144-9

Abstract Acrodermatitis enteropathica(AE) is caused by inherited or acquired zinc deficiency. Cutaneous clinical manifestations observed in AE include characteristic dermatitis on acral, periorificial and anogenital areas through an unknown mechanism. Recently, we found that mice fed a zinc-deficient diet develop a severe irritant contact dermatitis that has the histological features of the skin inflammation seen in AE patients. Read More

This finding highlights the possibility that the acral, periorificial and anogenital dermatitis in AE might be caused by contact with different irritants in daily life, such as chemicals, foods, urine or feces, respectively. This review focuses on the recent advances regarding the functional role of zinc in skin and describes how zinc deficiency causes various cutaneous manifestations.

Arch. Biochem. Biophys.
Arch Biochem Biophys 2016 Dec 7;611:113-119. Epub 2016 Jun 7.
Department of Dermatology, Faculty of Medicine, University of Yamanashi, Yamanashi, 409-3898, Japan.
JAAD Case Rep
JAAD Case Rep 2016 May 14;2(3):193-5. Epub 2016 May 14.
University of South Florida Department of Dermatology, Tampa, Florida.
JAMA 2016 May 24-31;315(20):2223-4
Division of Infectious Diseases and International Health, Department of Medicine, Duke University School of Medicine, Durham, North Carolina2Duke Clinical Research Institute, Duke University, Durham, North Carolina.