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Vemurafenib resistance selects for highly malignant brain and lung-metastasizing melanoma cells.Cancer Lett 2015 Feb 25. Epub 2015 Feb 25.V600E being the most common mutation in BRAF, leads to constitutive activation of the MAPK signaling pathway. The majority of V600E BRAF positive melanoma patients treated with the BRAF inhibitor vemurafenib showed initial good clinical responses but relapsed due to acquired resistance to the drug. The aim of the present study was to identify possible biomarkers associated with the emergence of drug resistant melanoma cells.Read More
Missing data imputation on the 5-year survival prediction of breast cancer patients with unknown discrete values.Comput Biol Med 2015 Feb 16;59C:125-133. Epub 2015 Feb 16.Breast cancer is the most frequently diagnosed cancer in women. Using historical patient information stored in clinical datasets, data mining and machine learning approaches can be applied to predict the survival of breast cancer patients. A common drawback is the absence of information, i.Read More
Prognostic Nomogram for Patients with Unresectable Hepatocellular Carcinoma After Transcatheter Arterial Chemoembolization.J Hepatol 2015 Feb 25. Epub 2015 Feb 25.To establish an effective prognostic nomogram for patients with unresectable hepatocellular carcinoma (HCC) after transarterial chemoembolization (TACE).
The nomogram was constructed based on data obtained from a retrospective study on 2938 patients who received TACE as an initial therapy from 2000 to 2008. The predictive accuracy and discriminative ability of the nomogram were compared with seven current commonly used staging systems on HCC by using data obtained from a prospective study on a cohort of 647 patients treated from January 2011 to December 2011 at the same institution.Read More
Radical Prostatectomy Findings in Men on Active Surveillance: Variable Findings Dependent on Reason for Surgery and Entry Criteria.J Urol 2015 Feb 25. Epub 2015 Feb 25.To study adverse findings in radical prostatectomy of men on an active surveillance program with different entry and exit criteria.
The study included 80 men with biopsy progression, 33 who opted-out for personal reasons, and 24 who initially did not meet entry criteria mainly due to elevated PSA density.
Men who opted-out had a higher Gleason score 6 (78.Read More
Manganoporphyrins and Ascorbate Enhance Gemcitabine Cytotoxicity in Pancreatic Cancer.Free Radic Biol Med 2015 Feb 25. Epub 2015 Feb 25.Pharmacological ascorbate (AscH(-)) selectively induces cytotoxicity in pancreatic cancer cells vs. normal cells via the generation of extracellular hydrogen peroxide (H2O2), producing double-stranded DNA breaks and ultimately cell death. Catalytic manganoporphyrins (MnPs) can enhance ascorbate-induced cytotoxicity by increasing the rate of AscH(-) oxidation and therefore the rate of generation of H2O2.Read More